DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1698 and RGD1562492

DIOPT Version :9

Sequence 1:	NP_001260835.1	Gene:	CG1698 / 36006	FlyBaseID:	FBgn0033443	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_001102616.1	Gene:	RGD1562492 / 499151	RGDID:	1562492	Length:	743	Species:	Rattus norvegicus

Alignment Length:	620	Identity:	160/620 - (25%)
Similarity:	278/620 - (44%)	Gaps:	116/620 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 EFLMSCIALSVGLGNVWRFPFTALENGGGAFVIPYLIVLILVGKPVYYLEMLLGQFSSRGSVKVY 146
            |.::..:|.|:|||:.||||:...:||||:|::.|||:|:|:|.|:.|:||::||:....:::.:
  Rat    57 ENILILVAFSIGLGSTWRFPYLCHQNGGGSFLLMYLILLLLLGIPLMYMEMVIGQWLRVDNIRAW 121

  Fly   147 -DFSPIMRGIGYGQVLATGIVTTYYATLMALTLRYFVDSF-YPTLPWSYCREEWGTECLDSGPQE 209
             ...|.:.|:||..:||..:|..|.:.|::.:|.|...|| ||| ||..|            |..
  Rat   122 KHLVPWLSGVGYSSMLACALVILYNSALVSWSLFYLGQSFDYPT-PWENC------------PLV 173

  Fly   210 ASRATSLAGSGVRTTSAEFYFTNIILREKASIDDGIGYPSWSLALALAVAWIVIAGIMFKGVKSS 274
            .:.:||.. |.:||...:|::.:.:||....|::||.....::.|.|...|..:...|...:|.|
  Rat   174 KNFSTSDI-SCLRTEPHQFFWYHTVLRASDQIEEGIEVLVLNVTLCLFATWFFLYITMVTRIKIS 237

  Fly   275 GKASYFLALFPYVVMLVLLVRALTLPGAFDGVLYFLRPQWHKLLEPQVWYAAVTQVFFSLAICFG 339
            .....|..|||.|::.........:.|..|.:...:..:...|.....|..|...|.:||.:..|
  Rat   238 VLMMIFSILFPNVLLFCFFTHIFFVKGVRDSLKRLVTTELSILASLDAWRQAGGHVLYSLGLGMG 302

  Fly   340 NIIMYASYNRFGHNIYRDANIVTTLDTFTSLLSGVIIFGIL-------GNLAYENNTTDIASVV- 396
            .||.::||...|.|..:.|:.|..::..|||||..:||.:|       |....|:|.:::.|::
  Rat   303 TIITFSSYQTRGENYIKWASFVAMVNLMTSLLSSSVIFLMLGFWIENSGTPCVESNVSNLLSLIA 367

  Fly   397 NG-----------------------------------------------------GPGLAFISYP 408
            ||                                                     |||||::::.
  Rat   368 NGVLPQVAWPPKDIIHRSPLEYLDWISQLPKNIRNEVAHFTLPCSILVQKEKFMEGPGLAYVAFS 432

  Fly   409 DAIAKFKWLPQLFSVLFFLMLFVLGIGSNVGMASCMSTVIKDQFGHLKNWTVVVGIAI-VGYFLG 472
            .||..|.. ...::::||:.|.::|:|:...:...::..::.....|:....:|.:.| :|.|||
  Rat   433 QAITLFPG-SSFWAIIFFMSLVIMGLGTMTTLVEGIALSLQKSISTLEKHPKLVPVIICLGGFLG 496

  Fly   473 -LLYITPGGQFLLNLVDYFGVTFVALVLAIFELVTIAWIYGVKRLCRDVEFMIGIKTSLYYRICW 536
             |::.:..|.:::.|.|...|..|.:::..|:.:::||:||:||...::...:|......:...|
  Rat   497 SLVFSSRPGSYVVFLFDDHLVPMVLIMIVAFQNLSLAWVYGIKRFRAEMFGQLGRLVWAPFTFLW 561

  Fly   537 AVVT-PLLMLTILIYTLVLY--EPLKYKDYT----------YQSGVYVFGWCLSAFGVGQVLFWA 588
            :.|| |.|::.:.||.|.||  |.|.|..:.          ||.  ...||         |.|.:
  Rat   562 SYVTLPTLLVLLTIYFLNLYFSESLSYVSWNNSMSQEVKQPYQR--IALGW---------VTFLS 615

  Fly   589 IPAVRKQPSHLGLWARIRKAFEPLPNWGPSDPQTL 623
            :.|:...|.:            ||.:|...|.|.:
  Rat   616 VLALLPIPMY------------PLQHWWYLDDQII 638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1698	NP_001260835.1	SLC6sbd	75..552	CDD:271359	141/535 (26%)
RGD1562492	NP_001102616.1	SLC5-6-like_sbd	50..621	CDD:382020	154/589 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820