DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1698 and slc6a1b

DIOPT Version :9

Sequence 1:	NP_001260835.1	Gene:	CG1698 / 36006	FlyBaseID:	FBgn0033443	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_001007363.1	Gene:	slc6a1b / 492490	ZFINID:	ZDB-GENE-041114-57	Length:	600	Species:	Danio rerio

Alignment Length:	621	Identity:	208/621 - (33%)
Similarity:	336/621 - (54%)	Gaps:	70/621 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 SSNGKKTLSEGS-----GSAPPPGHGDSPSGVEAGQPGKK----RDSWNNDIEFLMSCIALSVGL 94
            ::||.|. |:|.     ..||..  .|.|..:......||    |::|....:||:||:..::||
Zfish     2 ATNGTKA-SDGHVLTEVNEAPTA--NDKPKTLVVKVQKKKELPDRETWQGKFDFLLSCVGYAIGL 63

  Fly    95 GNVWRFPFTALENGGGAFVIPYLIVLILVGKPVYYLEMLLGQFSSRGSVKVYDFSPIMRGIGYGQ 159
            |||||||:...:||||||:|||.:.||..|.|:::||..|||::|.|.:.|:..:|:.:|:|...
Zfish    64 GNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFFLETALGQYTSIGGLGVWKLAPMFKGVGLAA 128

  Fly   160 VLATGIVTTYYATLMALTLRYFVDSFYPTLPWSYCREEWGTE-CLDSGPQEASRATSLAGSGVRT 223
            .:.:..:..||..::|..:.|..:||...|||..|...|.|: |..:        .|:|..|..|
Zfish   129 AVLSFWLNIYYIVIIAWAIYYLYNSFTTDLPWKSCDNPWNTDKCFSN--------YSMANIGNMT 185

  Fly   224 TS-AEFYFTNIILREKASIDDGIGYPS---WSLALALAVAWIVIAGIMFKGVKSSGKASYFLALF 284
            :: .||:..|:     ..:.||:..|.   ..||:.||:||:::...::|||..:||..||.|.:
Zfish   186 SAVVEFWERNM-----HQLTDGLEKPGEIRLPLAITLAIAWVLVYFCIWKGVGWTGKVVYFSATY 245

  Fly   285 PYVVMLVLLVRALTLPGAFDGVLYFLRPQWHKLLEPQVWYAAVTQVFFSLAICFGNIIMYASYNR 349
            ||.::.:|.:|.:|||||.:|:|:::.|::.||.|.:||..|.||:|||..:..|::|...|||.
Zfish   246 PYFMLFILFIRGVTLPGAKEGILFYVTPEFSKLKESEVWLDAATQIFFSYGLGLGSLIALGSYNP 310

  Fly   350 FGHNIYRDANIVTTLDTFTSLLSGVIIFGILGNLAYENNTTDIASVVNGGPGLAFISYPDAIAKF 414
            |.:|:|:|:.||..:::|||:.:|.:||.|:|.:|:... ..||.|...||||||::||:|:.:.
Zfish   311 FNNNVYKDSIIVCCINSFTSMFAGFVIFSIVGFMAHITK-RPIADVAASGPGLAFLAYPEAVTQL 374

  Fly   415 KWLPQLFSVLFFLMLFVLGIGSNVGMASCMSTVIKDQF-----GHLKNWTVVVGIAIVGYFLGLL 474
            ...| |::||||.||.:|||.|.........|.:.|:|     |..:.:..||  .:|.|.:||.
Zfish   375 PISP-LWAVLFFSMLLMLGIDSQFCTVEGFITALVDEFPRALRGRREIFIAVV--CLVSYLIGLS 436

  Fly   475 YITPGGQFLLNLVDYFGVTFVALV-LAIFELVTIAWIYGVKRLCRDVEFMIGIKTSLYYRICWAV 538
            .||.||.::..|.||:..:.:.|: |..||.|:|:|.|||.:...::|.|||.|..:::::||.|
Zfish   437 NITQGGLYVFKLFDYYSASGMCLLFLVFFECVSISWFYGVNKFYGNLEEMIGYKPCIWWKLCWVV 501

  Fly   539 VTPLLMLTILIYTLVLYEPLKYKDYTYQSGVYVFGWCLSAFGVGQVLFWAIPAVRKQPSHLGLW- 602
            .|||::..:.:::.|...||...:|.:.......|||:           |:.::...|.::|..
Zfish   502 FTPLIVAGVFLFSAVQMVPLTLNNYVFPKWGQGVGWCM-----------ALSSMVLIPGYMGYMF 555

  Fly   603 --------ARIRKAFEPL----------PNWGPSDP 620
                    .|:|...:|.          |...|.:|
Zfish   556 LTLKGSYKERLRIMIQPTAAAVRTQENGPEQQPENP 591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1698	NP_001260835.1	SLC6sbd	75..552	CDD:271359	180/487 (37%)
slc6a1b	NP_001007363.1	SLC5-6-like_sbd	2..600	CDD:294310	208/621 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820