Protein Alignment CG1698 and Slc6a4

DIOPT Version :9

• Sequence 1: NP_001260835.1
• Gene: CG1698 / 36006
• FlyBaseID: FBgn0033443
• Length: 654
• Species: Drosophila melanogaster
• Sequence 2: NP_037166.2
• Gene: Slc6a4 / 25553
• RGDID: 3714
• Length: 630
• Species: Rattus norvegicus
• Alignment Length: 648
• Identity: 215/648 - (33%)
• Similarity: 339/648 - (52%)
• Gaps: 71/648 - (10%)

  Fly     1 METTINNNN------------NDNGYMNQAYVGSLNASTISIPGAYKPNESSNGKKTLSEGSGSA 53
            ||||..|:.            .:||.:.:           .:|......|.|.    :|.|..:.
  Rat     1 METTPLNSQKVLSECKDREDCQENGVLQK-----------GVPTTADRAEPSQ----ISNGYSAV 50

  Fly    54 PPPGHGDSPS------------GVEAGQPGKKRDSWNNDIEFLMSCIALSVGLGNVWRFPFTALE 106
            |....||..|            .:..|:    |::|...::||:|.|..:|.|||:||||:...:
  Rat    51 PSTSAGDEASHSIPAATTTLVAEIRQGE----RETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQ 111

  Fly   107 NGGGAFVIPYLIVLILVGKPVYYLEMLLGQFSSRGSVKVY-DFSPIMRGIGYGQVLATGIVTTYY 170
            ||||||::||.|:.|..|.|::|:|:.|||:...|.:.:: ...||.:||||...:....:.:||
  Rat   112 NGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYY 176

  Fly   171 ATLMALTLRYFVDSFYPTLPWSYCREEWGT-ECLDSGPQEASRATSLAGSGVRTTS--AEFYFTN 232
            .|::|..|.|.:.|....|||:.|...|.| .|.:...|:....|      :.:||  .|||..:
  Rat   177 NTIIAWALYYLISSLTDRLPWTSCTNSWNTGNCTNYFAQDNITWT------LHSTSPAEEFYLRH 235

  Fly   233 II-LREKASIDDGIGYPSWSLALALAVAWIVIAGIMFKGVKSSGKASYFLALFPYVVMLVLLVRA 296
            :: :.:...:.| :|..||.|.|.:.:.:.||...::||||:|||..:..|.|||:|:.|||||.
  Rat   236 VLQIHQSKGLQD-LGTISWQLTLCIVLIFTVIYFSIWKGVKTSGKVVWVTATFPYIVLSVLLVRG 299

  Fly   297 LTLPGAFDGVLYFLRPQWHKLLEPQVWYAAVTQVFFSLAICFGNIIMYASYNRFGHNIYRDANIV 361
            .|||||:.||:::|:|.|.||||..||..|..|:||||...||.::.:||||:|.:|.|:||.:.
  Rat   300 ATLPGAWRGVVFYLKPNWQKLLETGVWVDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVT 364

  Fly   362 TTLDTFTSLLSGVIIFGILGNLAYENNTTDIASVV-NGGPGLAFISYPDAIAKFKWLP--QLFSV 423
            :.::..||.:||.:||.:||.:| |....|::.|. :.||.|.||:|.:|||.   :|  ..|::
  Rat   365 SVVNCMTSFVSGFVIFTVLGYMA-EMRNEDVSEVAKDAGPSLLFITYAEAIAN---MPASTFFAI 425

  Fly   424 LFFLMLFVLGIGSNVGMASCMSTVIKDQFGHL----KNWTVVVGIAIVGYFLG-LLYITPGGQFL 483
            :|||||..||:.|.......:.|.:.|:|.|:    :.|.|:  |.::...|| ||.:|.||.::
  Rat   426 IFFLMLITLGLDSTFAGLEGVITAVLDEFPHIWAKRREWFVL--IVVITCVLGSLLTLTSGGAYV 488

  Fly   484 LNLVDYFGVTFVALVLAIFELVTIAWIYGVKRLCRDVEFMIGIKTSLYYRICWAVVTPLLMLTIL 548
            :.|::.:......|.:|:.|.|.::|.||:.:.|.||:.|:|.....::||||..::||.:|.|:
  Rat   489 VTLLEEYATGPAVLTVALIEAVAVSWFYGITQFCSDVKEMLGFSPGWFWRICWVAISPLFLLFII 553

  Fly   549 IYTLVLYEPLKYKDYTYQSGVYVFGWCLSAFGVGQVLFWAIPAVRKQPSHLGLWARIRKAFEP 611
            ...|:....|:...|.|.....|.|:|:....|..:..:.|..:...|..|.  .||.|:..|
  Rat   554 CSFLMSPPQLRLFQYNYPHWSIVLGYCIGMSSVICIPTYIIYRLISTPGTLK--ERIIKSITP 614

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1698	NP_001260835.1	SLC6sbd	75..552	CDD:271359	182/489 (37%)
Slc6a4	NP_037166.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	23..60		10/51 (20%)
		5HT_transport_N	24..64	CDD:397524	11/54 (20%)
		SLC6sbd_SERT	79..615	CDD:271399	198/551 (36%)
		Interaction with RAB4A. /evidence=ECO:0000250	616..624

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920