DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1698 and Slc6a6

DIOPT Version :9

Sequence 1:	NP_001260835.1	Gene:	CG1698 / 36006	FlyBaseID:	FBgn0033443	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	XP_030111163.1	Gene:	Slc6a6 / 21366	MGIID:	98488	Length:	631	Species:	Mus musculus

Alignment Length:	539	Identity:	213/539 - (39%)
Similarity:	309/539 - (57%)	Gaps:	23/539 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 PPPGH--GDSPSGVEAGQPGKKRDSWNNDIEFLMSCIALSVGLGNVWRFPFTALENGGGAFVIPY 116
            |.||.  |..|.....|:| .:|:.|::.|:|::|.....||||||||||:...:||||||:|||
Mouse    30 PSPGKSPGTRPEDEADGKP-PQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPY 93

  Fly   117 LIVLILVGKPVYYLEMLLGQFSSRGSVKVYD-FSPIMRGIGYGQVLATGIVTTYYATLMALTLRY 180
            .|.|...|.||::||:::||::|.|.:..:: ..|:..||||..::...::..||..::|....|
Mouse    94 FIFLFGSGLPVFFLEVIIGQYTSEGGITCWEKICPLFSGIGYASIVIVSLLNVYYIVILAWATYY 158

  Fly   181 FVDSFYPTLPWSYCREEWGT-ECL-DSGPQEASRATSLAGSGVRTTSAEFYFTNIILREKASIDD 243
            ...||...|||::|...|.| :|: |:..:..|...||:.:...:...||:..|::     |:..
Mouse   159 LFHSFQKDLPWAHCNHSWNTPQCMEDTLRRNESHWVSLSTANFTSPVIEFWERNVL-----SLSS 218

  Fly   244 GIGYP---SWSLALALAVAWIVIAGIMFKGVKSSGKASYFLALFPYVVMLVLLVRALTLPGAFDG 305
            ||..|   .|.|||.|.:.|:|....::|||:|:||..||.|.||:.::||||||.||||||.:|
Mouse   219 GIDNPGSLKWDLALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGLTLPGAGEG 283

  Fly   306 VLYFLRPQWHKLLEPQVWYAAVTQVFFSLAICFGNIIMYASYNRFGHNIYRDANIVTTLDTFTSL 370
            :.::|.|...:|.:||||..|.||:|||.|||.|.:....|||::.:|.|||..::..|::.||.
Mouse   284 IKFYLYPDISRLGDPQVWIDAGTQIFFSYAICLGAMTSLGSYNKYKYNSYRDCMLLGCLNSGTSF 348

  Fly   371 LSGVIIFGILGNLAYENNTTDIASVVNGGPGLAFISYPDAIAKFKWLPQLFSVLFFLMLFVLGIG 435
            :||..||.|||.:|.|.. .|||.|...|||||||:||.|:.... ||..:|:|||:||.:||:.
Mouse   349 VSGFAIFSILGFMAQEQG-VDIADVAESGPGLAFIAYPKAVTMMP-LPTFWSILFFIMLLLLGLD 411

  Fly   436 SNVGMASCMSTVIKDQFGHL--KNWTVVVGIAI---VGYFLGLLYITPGGQFLLNLVDYFGVTFV 495
            |.........|.:.|.:...  |.:...:.|||   :.|.|||..:|.||.::..|.||:..:.|
Mouse   412 SQFVEVEGQITSLVDLYPSFLRKGYRREIFIAILCSISYLLGLTMVTEGGMYVFQLFDYYAASGV 476

  Fly   496 ALV-LAIFELVTIAWIYGVKRLCRDVEFMIGIKTSLYYRICWAVVTPLLMLTILIYTLVLYEPLK 559
            .|: :|.||...||||||...|...:|.|||.:...:.:..|||:||.|.:...:::||.|.||.
Mouse   477 CLLWVAFFECFVIAWIYGGDNLYDGIEDMIGYRPGPWMKYSWAVITPALCVGCFVFSLVKYVPLT 541

  Fly   560 Y-KDYTYQSGVYVFGWCLS 577
            | |.|.|.......||.|:
Mouse   542 YNKVYRYPDWAIGLGWGLA 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1698	NP_001260835.1	SLC6sbd	75..552	CDD:271359	193/488 (40%)
Slc6a6	XP_030111163.1	SLC5-6-like_sbd	51..592	CDD:382020	206/517 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820