DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1698 and Slc6a2

DIOPT Version :9

Sequence 1:	NP_001260835.1	Gene:	CG1698 / 36006	FlyBaseID:	FBgn0033443	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_033235.3	Gene:	Slc6a2 / 20538	MGIID:	1270850	Length:	617	Species:	Mus musculus

Alignment Length:	562	Identity:	215/562 - (38%)
Similarity:	313/562 - (55%)	Gaps:	40/562 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 QPGKKRDSWNNDIEFLMSCIALSVGLGNVWRFPFTALENGGGAFVIPYLIVLILVGKPVYYLEML 133
            ||   |::|...|:||:|.:..:|.|.||||||:...:||||||:|||.:.||:.|.|::|:|:.
Mouse    54 QP---RETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELA 115

  Fly   134 LGQFSSRGSVKVYDFSPIMRGIGYGQVLATGIVTTYYATLMALTLRYFVDSFYPTLPWSYCREEW 198
            |||::..|:..|:...|..:|:||..:|....|..||..::|.:|.|...||...|||:.|...|
Mouse   116 LGQYNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFASFTLNLPWTNCGHSW 180

  Fly   199 GT-ECLDSGPQEASRATSLAGSGVR------TTSAEFYFTNII-LREKASIDDGIGYPSWSLALA 255
            .: .|.|.....|    |:.|...:      |.:||||...:: |.|.:.|.| ||.|.|.|.|.
Mouse   181 NSPNCTDPKLLNA----SVLGDHTKYSKYKFTPAAEFYERGVLHLHESSGIHD-IGLPQWQLLLC 240

  Fly   256 LAVAWIVIAGIMFKGVKSSGKASYFLALFPYVVMLVLLVRALTLPGAFDGVLYFLRPQWHKLLEP 320
            |.|..:|:...::||||:|||..:..|..||.|:.||||..:|||||.:|:..:|...:::|.|.
Mouse   241 LMVVIVVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFYRLKEA 305

  Fly   321 QVWYAAVTQVFFSLAICFGNIIMYASYNRFGHNIYRDANIVTTLDTFTSLLSGVIIFGILGNLAY 385
            .||..|.||:||||...||.:|.:||||:|.:|.||||.:.:|::..||.:||..||.|||.:|:
Mouse   306 TVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSTINCVTSFISGFAIFSILGYMAH 370

  Fly   386 ENNTTDIASVVNGGPGLAFISYPDAIAKFK----WLPQLFSVLFFLMLFVLGIGSNVGMASCMST 446
            |:. .:|..|...|.||.||.||:||:...    |     :|||||||..||:.|::|....:.|
Mouse   371 EHK-VNIEDVATEGAGLVFILYPEAISTLSGSTFW-----AVLFFLMLLALGLDSSMGGMEAVIT 429

  Fly   447 VIKDQF----GHLKNWTVVVGIAIVGYFLGLLYITPGGQFLLNLVDYFGVTFVALVLAIFELVTI 507
            .:.|.|    .|.|.:|.||.|:.  :.|.|..||.||.::|.|:|.|......|...:.|.:.:
Mouse   430 GLADDFQVLKRHRKLFTCVVTIST--FLLALFCITKGGIYVLTLLDTFAAGTSILFAVLMEAIGV 492

  Fly   508 AWIYGVKRLCRDVEFMIGIKTSLYYRICWAVVTPLLMLTILIYTLVLYEPLKYKDYTYQSGVYVF 572
            :|.|||.|...|::.|:|.|..||:|:||..|:|..:|.:::.:::.::||.|.||||.......
Mouse   493 SWFYGVDRFSNDIQQMMGFKPGLYWRLCWKFVSPAFLLFVVVVSIINFKPLTYDDYTYPPWANWV 557

  Fly   573 GWCLSAFGVGQVLFWAIPA--VRKQPSHLG-LWARIRKAFEP 611
            ||     |:.......:||  :.|..|..| ||.|:.....|
Mouse   558 GW-----GIALSSMILVPAYVIYKFLSIRGSLWERVAYGITP 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1698	NP_001260835.1	SLC6sbd	75..552	CDD:271359	193/492 (39%)
Slc6a2	NP_033235.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
Slc6a2	NP_033235.3	SLC5-6-like_sbd	56..615	CDD:382020	213/557 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820