DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1698 and slc6a19a.2

DIOPT Version :9

Sequence 1:	NP_001260835.1	Gene:	CG1698 / 36006	FlyBaseID:	FBgn0033443	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	XP_002665492.2	Gene:	slc6a19a.2 / 100334171	ZFINID:	ZDB-GENE-141210-16	Length:	647	Species:	Danio rerio

Alignment Length:	613	Identity:	186/613 - (30%)
Similarity:	314/613 - (51%)	Gaps:	103/613 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 EAGQPGKKRDSWNNDIEFLMSCIALSVGLGNVWRFPFTALENGGGAFVIPYLIVLILVGKPVYYL 130
            |||:    |..|:|..:::::|:...||||||||||:....:|||||:||:||:|:|.|.|:.:|
Zfish    29 EAGE----RPKWDNKAQYMLTCVGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVLEGIPLLHL 89

  Fly   131 EMLLGQFSSRGSVKVY-DFSPIMRGIGYGQVLATGIVTTYYATLMALTLRYFVDSFYPTLPWSYC 194
            |..:||...||||.|: ..:|.:.|:|...:|.:.||..||.|::|..:.||.:||...||||.|
Zfish    90 EFAIGQRLRRGSVGVWRSINPYLLGVGIASMLVSFIVGMYYNTIIAWVMWYFFNSFQDPLPWSQC 154

  Fly   195 REEWGTECLDSGPQEASRATSLAGSGVRTTSAEFYFTNIILREKASIDDGIGYPSWSLALALAVA 259
                        |...|| |.......|::..::::....|.....|:|..|. .|.:.|:|..|
Zfish   155 ------------PINGSR-TGFVSECERSSPVDYFWYRKTLNTTPHIEDSGGL-QWWMVLSLLCA 205

  Fly   260 WIVIAGIMFKGVKSSGKASYFLALFPYVVMLVLLVRALTLPGAFDGVLYFLRPQWHKLLEPQVWY 324
            |.|:.....:|::::|||.|..:..||:|:.:.|:|.|||.|:..|:.:...|..::||:||.|.
Zfish   206 WTVLWVCCIRGIETTGKAVYITSTLPYLVLTIFLIRGLTLKGSVSGIKFLFTPDVNELLDPQTWL 270

  Fly   325 AAVTQVFFSLAICFGNIIMYASYNRFGHNIYRDANIVTTLDTFTSLLSGVIIFGILGNLAYEN-- 387
            .|..|||||.::.||.:|.::|||...:|..:||.|::.::..||:.:.::|:.|:|..|.|.
Zfish   271 DAGAQVFFSFSLAFGGLIAFSSYNSVHNNCEQDAVIISIINGMTSIYAAIVIYSIIGFRATERFD 335

  Fly   388 -----------NTTDI--ASVVNG------------------------------------GPGLA 403
                       |..|:  .|::.|                                    |.|||
Zfish   336 DCLNGNILSLLNAFDLPEGSIIEGNYTEAIQQLNISRPDIIQELQLKTCDMQTFLSQGVEGTGLA 400

  Fly   404 FISYPDAIAKFKWLPQLFSVLFFLMLFVLGIGSNVGMASCMSTVIKDQFGHLKNW-----TVVVG 463
            ||.:.:||.|....| |:|||||:|||.||:.:..|....:...::|.....|||     |.:|
Zfish   401 FIVFTEAITKMPVSP-LWSVLFFIMLFCLGLSTMFGSIEGVVVPLQDLDILPKNWPKEAYTALV- 463

  Fly   464 IAIVGYFLGLLYITPGGQFLLNLVDYFGVTFVALVLAIFELVTIAWIYGVKRLCRDVEFMIGIKT 528
             .:|.:...:::....|::.|.|.|.|.|:...|::|..|::.::::||:.|...|::||||.|.
Zfish   464 -CVVSFAFAIIFAQGSGEYWLALFDGFAVSIPLLIIAFCEMMAVSYVYGIDRFNDDIKFMIGHKP 527

  Fly   529 SLYYRICWAVVTPLLMLTILIY----------TLVLYEPLKYKDYTYQSGVYVFGWCLSA--FGV 581
            :::::..|.:::||::|.|.::          |.:.::| :.:::...|.:...|| :||  |.:
Zfish   528 NIFWQATWRLISPLIVLVIFLFYFVTTVSKKLTYIAWDP-ESENFPTLSVLPYPGW-ISAIIFIL 590

  Fly   582 GQVLFWAIPAV-----------RKQPSH 598
            ..:....||.|           :|:.:|
Zfish   591 AGIPVLVIPTVALVRLIRNRCCKKEETH 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1698	NP_001260835.1	SLC6sbd	75..552	CDD:271359	169/543 (31%)
slc6a19a.2	XP_002665492.2	SLC5-6-like_sbd	33..613	CDD:294310	181/598 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810