DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1698 and slc6a14

DIOPT Version :9

Sequence 1:	NP_001260835.1	Gene:	CG1698 / 36006	FlyBaseID:	FBgn0033443	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_001313379.1	Gene:	slc6a14 / 100150665	ZFINID:	ZDB-GENE-130411-2	Length:	614	Species:	Danio rerio

Alignment Length:	572	Identity:	208/572 - (36%)
Similarity:	331/572 - (57%)	Gaps:	30/572 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 DSPSGVEAGQPGKKRDSWNNDIEFLMSCIALSVGLGNVWRFPFTALENGGGAFVIPYLIVLILVG 124
            |....|........|.:|::..|:::|.|..:||||||||||:.|.::|||||:|||.|:|.:.|
Zfish    28 DKAEHVVQNDENSDRGNWSSKREYMLSMIGYAVGLGNVWRFPYLAYKHGGGAFLIPYTIMLAVSG 92

  Fly   125 KPVYYLEMLLGQFSSRGSVKVYDFSPIMRGIGYGQVLATGIVTTYYATLMALTLRYFVDSFYPTL 189
            .|::::|...|||.|:|.:.|:...||::|:|...:|.:..|..||..::|.::.|...||...|
Zfish    93 LPLFFMESSFGQFCSQGPINVWKAVPILQGVGITMMLVSTFVAIYYNVIIAYSIYYLFASFQDPL 157

  Fly   190 PWSYCREEWGTECLDSGPQEASRATSLAGSGVRTTS-AEFYFTNIILREKASIDDGIGYPSWSLA 253
            |||.      ..|..:....::.|.:::...:...| :|.|:..:.|:..:|:|: .|...|.||
Zfish   158 PWSI------KNCNTTASNISTAAVNVSCGQISGQSLSEKYWDEVALQRSSSMDE-TGPVVWHLA 215

  Fly   254 LALAVAWIVIAGIMFKGVKSSGKASYFLALFPYVVMLVLLVRALTLPGAFDGVLYFLRPQWH--K 316
            |.|.::||::...:|||:|||||..||.|.|||:|:|:||:|..||.||.||:.:::..|.:  |
Zfish   216 LCLLLSWILVGAALFKGIKSSGKVVYFTATFPYIVLLILLIRGATLEGAKDGIEFYIGSQSNLTK 280

  Fly   317 LLEPQVWYAAVTQVFFSLAICFGNIIMYASYNRFGHNIYRDANIVTTLDTFTSLLSGVIIFGILG 381
            |.|.:||..|.||:||||:|.:|.::..:|||:|.:|.|:|:.:|...:..||:.:|..||.:||
Zfish   281 LAEAEVWKDAATQIFFSLSIAWGGLMALSSYNKFYNNCYQDSIVVCVTNCGTSIFAGFAIFSVLG 345

  Fly   382 NLA--YENNTTDIASVVNGGPGLAFISYPDAIAKFKWLPQLFSVLFFLMLFVLGIGSNVGMASCM 444
            ::|  |:...:::|   :.|..||||:||||::|....| |:|:|||.||..||:.|.......:
Zfish   346 HMAHVYQRPVSEVA---DAGFALAFIAYPDALSKLPISP-LWSILFFFMLITLGLDSQFAGIEVI 406

  Fly   445 STVIKDQFGHL---KNWTVVVGIAIVGYFLGLLYITPGGQFLLNLVDYFGVTFVALVLAIFELVT 506
            ||.:.|.:..:   |...|...:.|:.:.|||..:|..|.:.:||:|.|...::.||..:.|::.
Zfish   407 STCLLDAYPEVLKSKRGLVTTAVCIILFLLGLPCVTRAGIYWVNLIDTFSAGWILLVAGLLEVLG 471

  Fly   507 IAWIYGVKRLCRDVEFMIGIKTSLY---YRICWAVVTPLLMLTILIYTLVLYEPLKYKDYTYQSG 568
            :..:||..|..:|:|.|||.|:||:   :|.||..:||:::..|||::|..:....|....|...
Zfish   472 LCILYGGNRFIKDIEMMIGTKSSLFWLWWRACWFFITPVVLSIILIWSLYTFTSPTYSSVAYPDW 536

  Fly   569 VYVFGWCLSAFGVGQVLFWAIPAV---RKQPSHLGLWARIRKAFEPLPNWGP 617
            ....|||::||.    |.| ||.|   :...:..|||.||:.|..|..:|||
Zfish   537 GISLGWCITAFS----LMW-IPIVAVWKVCKARGGLWQRIKSACSPTEDWGP 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1698	NP_001260835.1	SLC6sbd	75..552	CDD:271359	182/487 (37%)
slc6a14	NP_001313379.1	SLC6sbd_ATB0	42..612	CDD:271391	206/558 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920