DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG1688 and Kcnb2

DIOPT Version :10

Sequence 1:NP_610516.1 Gene:CG1688 / 36005 FlyBaseID:FBgn0027589 Length:918 Species:Drosophila melanogaster
Sequence 2:NP_001091998.1 Gene:Kcnb2 / 98741 MGIID:99632 Length:907 Species:Mus musculus


Alignment Length:797 Identity:154/797 - (19%)
Similarity:261/797 - (32%) Gaps:240/797 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    54 LTAKPRSSLRRCCGHLLKLLFSTPGLVLLVIGYSVLGGLLFPLLE-----APQDISKSAAIAK-- 111
            |..||.||:......::.:||    :||..|..|:  ..|..|.|     .|.|..|.|.:..  
Mouse   182 LLEKPNSSVAAKILAIVSILF----IVLSTIALSL--NTLPELQENDEFGQPSDNRKLAHVEAVC 240

  Fly   112 ----SREDCLREL-----W-IITEKLNV--------------LYERNWTMLVHEQLRR----FEG 148
                :.|..||.|     | .....|||              |.|.|.::|..:.:||    |..
Mouse   241 IAWFTMEYLLRFLSSPNKWKFFKGPLNVIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRI 305

  Fly   149 SIVAATRQGSAGSSGGGGAGLFHEGSASALG-----------------HFGYDAGDSQSWSFSEA 196
            ..:....:.:..|:|....|.....|.:.||                 .|.....|:..::...|
Mouse   306 MRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDATKFTSIPA 370

  Fly   197 LLYSVTV-ITTIGHGSLTPRTAAGKLATIFYALVGVPLMLMCLSSLGALLADGLQCTYVRLCCQL 260
            ..:..|: :||:|:|.:.|:|..||:......:.||.::.:.:    .::.:.....|     :.
Mouse   371 SFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPI----PIIVNNFSEFY-----KE 426

  Fly   261 QRHQEHRRKSTPGTSTPSAS-SAANSREKDTDKRSKRRMANCKGCQYDAANSETSLNDCLEYGQK 324
            |:.||...|..........: |..:...||...||...:........::||::.|::|       
Mouse   427 QKRQEKAIKRREALERAKRNGSIVSMNLKDAFARSMELIDVAVEKAGESANTKDSVDD------- 484

  Fly   325 GKLPPDKKEGDACQLLRNLNPQQHFYQQQQQQPQQPDVMLMTTTSGSALLKYAPQQQQLQQQQQL 389
            ..|.|.:.:. |.:.|...:..:.:..:.|:..|......:..||.|     :||....|:.:.|
Mouse   485 NHLSPSRWKW-ARKALSETSSNKSYENKYQEVSQNDSHEHLNNTSSS-----SPQHLSAQKLEML 543

  Fly   390 ---STATLPRQHHQMQLQQQ-------QQQLQQNFVAVPSSMLR---------MPLTVPPNCYAP 435
               .|.|.|..|.....|:|       :::::...|..|...|.         |..|...:.:. 
Mouse   544 YNEITKTQPHSHPNPDCQEQPERPCVYEEEIEMEEVICPQEQLAVAQTEVIVDMKSTSSIDSFT- 607

  Fly   436 ATATIYFPFGHAPSAPGSPAHNQAHPTQNPNGNALGNTTLGSQPLVKYHTIHLQPASGKHRVLAS 500
            :.||.:.....:|..|.|.:|.|                      :|:.|.  .|.:.:|     
Mouse   608 SCATDFTETERSPLPPPSASHLQ----------------------MKFPTD--LPGTDEH----- 643

  Fly   501 GLQDATAVNLVTASEASTSTLEAITLPPPPAYQTASVHAVRRAKFVAKPLPQEINALMDCGTGSP 565
              |.|.|...:|.|.           ...||.:.|:|...          |.:|...:|.|..  
Mouse   644 --QRARAPPFLTLSR-----------DKGPAAREAAVDYA----------PIDITVNLDAGAS-- 683

  Fly   566 DLSGRHDLLPPPHSGSPATGTAASPLLTYTAAATSPQLSAGIKGGSGPAPTAGAPMLVS-GAGRG 629
                 |..|.|                  .:|:.||:.|  :||.:   |.....:.|: ...|.
Mouse   684 -----HGPLQP------------------DSASDSPKSS--LKGSN---PLKSRSLKVNFQENRA 720

  Fly   630 AAALTDNGFMAAGVCGMGAAAAPLPVTSMGAATTTASSAASTLSALLSANSTGNVDIMEDEDEQE 694
            :|..|.           .:.|.|||||:.....||....::.|  |..|...|...::|.:|.  
Mouse   721 SAPQTP-----------PSTARPLPVTTADFPLTTPQHMSTIL--LEEALPQGQPPLLEADDS-- 770

  Fly   695 RERLSNCPHGTPSRVPLIASPLSVPQDSGENTTRNTAFNRHTLQPLSRKTLLLTRRCHRHASGTL 759
                ::|                    .|.:...:..|.:..|.|.|.:    .||         
Mouse   771 ----AHC--------------------QGPSKGFSPRFPKQKLFPFSSR----ERR--------- 798

  Fly   760 YDSTANNTETSDDEEYM 776
               :....:|.:||:::
Mouse   799 ---SFTEIDTGEDEDFL 812

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG1688NP_610516.1 Ion_trans_2 177..247 CDD:462301 16/87 (18%)
Ion_trans_2 822..896 CDD:462301
Kcnb2NP_001091998.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..22
BTB_POZ_KCNB2 19..145 CDD:349719
Ion_trans 192..428 CDD:459842 49/250 (20%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 381..386 2/4 (50%)
Kv2channel 471..755 CDD:397541 76/392 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 503..534 6/35 (17%)
FFAT. /evidence=ECO:0000250|UniProtKB:Q92953 605..611 0/6 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 680..742 21/102 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 761..859 13/94 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 887..907
Blue background indicates that the domain is not in the aligned region.

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