DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG1688 and KCNB2

DIOPT Version :10

Sequence 1:NP_610516.1 Gene:CG1688 / 36005 FlyBaseID:FBgn0027589 Length:918 Species:Drosophila melanogaster
Sequence 2:NP_004761.2 Gene:KCNB2 / 9312 HGNCID:6232 Length:911 Species:Homo sapiens


Alignment Length:797 Identity:158/797 - (19%)
Similarity:261/797 - (32%) Gaps:241/797 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    54 LTAKPRSSLRRCCGHLLKLLFSTPGLVLLVIGYSVLGGLLFPLLEAPQ--DISKSAAIAKSREDC 116
            |..||.||:......::.:||    :||..|..|:  ..|..|.|..:  .::.:..:|.....|
Human   182 LLEKPNSSVAAKILAIVSILF----IVLSTIALSL--NTLPELQETDEFGQLNDNRQLAHVEAVC 240

  Fly   117 LRELWIITE-----------------KLNV--------------LYERNWTMLVHEQLRR----F 146
            :  .|...|                 .|||              |.|.|.::|..:.:||    |
Human   241 I--AWFTMEYLLRFLSSPNKWKFFKGPLNVIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIF 303

  Fly   147 EGSIVAATRQGSAGSSGGGGAGLFHEGSASALG-----------------HFGYDAGDSQSWSFS 194
            ....:....:.:..|:|....|.....|.:.||                 .|.....|:..::..
Human   304 RIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDATKFTSI 368

  Fly   195 EALLYSVTV-ITTIGHGSLTPRTAAGKLATIFYALVGVPLMLMCLSSLGALLADGLQCTYVRLCC 258
            .|..:..|: :||:|:|.:.|:|..||:......:.||.::.:.:    .::.:.....|     
Human   369 PASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPI----PIIVNNFSEFY----- 424

  Fly   259 QLQRHQEHRRKSTPGTSTPSAS-SAANSREKDTDKRSKRRMANCKGCQYDAANSETSLNDCLEYG 322
            :.|:.||...|..........: |..:...||...||...:........::||::.|.:|     
Human   425 KEQKRQEKAIKRREALERAKRNGSIVSMNLKDAFARSMELIDVAVEKAGESANTKDSADD----- 484

  Fly   323 QKGKLPPDKKEGDACQLLRNLNPQQHFYQQQQQQPQQPDVMLMTTTSGSALLKYAPQQQQLQQQQ 387
              ..|.|.:.:. |.:.|...:..:.|..:.|:..|:.....:..||.|     :||....|:.:
Human   485 --NHLSPSRWKW-ARKALSETSSNKSFENKYQEVSQKDSHEQLNNTSSS-----SPQHLSAQKLE 541

  Fly   388 QL---STATLPRQHHQMQLQQQ-------QQQLQQNFVAVPSSMLRMPLTVP------------- 429
            .|   .|.|.|..|.....|::       :::::...|..|...|.:..|..             
Human   542 MLYNEITKTQPHSHPNPDCQEKPERPSAYEEEIEMEEVVCPQEQLAVAQTEVIVDMKSTSSIDSF 606

  Fly   430 PNCYAPATATIYFPFGHAPSA-----------PGSPAHNQAH-----PTQNPNGNALGNTTLGSQ 478
            .:|....|.|...|. ..|||           ||:..|.:|.     ......|.|..:.||...
Human   607 TSCATDFTETERSPL-PPPSASHLQMKFPTDLPGTEEHQRARGPPFLTLSREKGPAARDGTLEYA 670

  Fly   479 PLVKYHTIHLQPASGKHRVLASGLQDATAVNLVTASEASTSTLEAITL------------PPPPA 531
            |:  ..|::|. |||....|.|.||...|.:...:|...::.|::.:|            ..||:
Human   671 PV--DITVNLD-ASGSQCGLHSPLQSDNATDSPKSSLKGSNPLKSRSLKVNFKENRGSAPQTPPS 732

  Fly   532 YQTASVHAVRRAKFVAKPLPQEINALMDCGTGSPDLSGRHDLLPPPHSGS-PATGTAASPLLTYT 595
              ||....|..|.| :...||.|:.::              |...|..|. |..||         
Human   733 --TARPLPVTTADF-SLTTPQHISTIL--------------LEETPSQGDRPLLGT--------- 771

  Fly   596 AAATSPQLSAGIKGGS-GPAPTAGAPMLVSGAGRGAAALTDNGFMAAGVCGMGAAAAPLPVTSMG 659
                  ::||..:|.| |.:|......|...:.|...:.|:                        
Human   772 ------EVSAPCQGPSKGLSPRFPKQKLFPFSSRERRSFTE------------------------ 806

  Fly   660 AATTTASSAASTLSALLSANSTGNVDIMEDED---------EQERERLSNCPHGTPS--RVPL-- 711
                                    :|..:|||         |::.:...||....||  |.||  
Human   807 ------------------------IDTGDDEDFLELPGAREEKQVDSSPNCFADKPSDGRDPLRE 847

  Fly   712 ---IASPLSVPQDSGEN 725
               :.|  |.|||:|.|
Human   848 EGSVGS--SSPQDTGHN 862

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG1688NP_610516.1 Ion_trans_2 177..247 CDD:462301 16/87 (18%)
Ion_trans_2 822..896 CDD:462301
KCNB2NP_004761.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..22
BTB_POZ_KCNB2 19..145 CDD:349719
Ion_trans 192..428 CDD:459842 44/252 (17%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 381..386 2/4 (50%)
Kv2channel 471..759 CDD:397541 67/321 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 503..534 7/35 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 549..571 4/21 (19%)
FFAT. /evidence=ECO:0000269|PubMed:33124732 605..611 1/5 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 637..665 6/27 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 685..739 12/55 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 760..865 33/168 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 892..911
Blue background indicates that the domain is not in the aligned region.

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