DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1688 and KCNK17

DIOPT Version :9

Sequence 1:	NP_610516.1	Gene:	CG1688 / 36005	FlyBaseID:	FBgn0027589	Length:	918	Species:	Drosophila melanogaster
Sequence 2:	NP_113648.2	Gene:	KCNK17 / 89822	HGNCID:	14465	Length:	332	Species:	Homo sapiens

Alignment Length:	199	Identity:	58/199 - (29%)
Similarity:	89/199 - (44%)	Gaps:	52/199 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 AKPRSSLRRCCGHLLKLLFSTPGLVLLV---IGYSVLGGLLFPLLE--APQDISKSAAIAKSRED 115
            |.|...:|.|         :.|..|||:   :.|..||..:|..||  |.||.|:|..
Human     8 AAPEGRVRGC---------AVPSTVLLLLAYLAYLALGTGVFWTLEGRAAQDSSRSFQ------- 56

  Fly   116 CLRELWIITEKLNVLYERNWTMLVHEQLRRFEGSIVAATRQGSAGSSGGGGAGLFHEGSASALGH 180
              |:.|.:.:        |:|.|....|......:|.|.:.|::..|           :.:::|.
Human    57 --RDKWELLQ--------NFTCLDRPALDSLIRDVVQAYKNGASLLS-----------NTTSMGR 100

  Fly   181 FGYDAGDSQSWSFSEALLYSVTVITTIGHGSLTPRTAAGKLATIFYALVGVPLMLMCLSSLGALL 245
                      |....:..:||:.|||||:|:|:|.|.|.:|..||:||||:||.|:.|:.||.|:
Human   101 ----------WELVGSFFFSVSTITTIGYGNLSPNTMAARLFCIFFALVGIPLNLVVLNRLGHLM 155

  Fly   246 ADGL 249
            ..|:
Human   156 QQGV 159

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1688	NP_610516.1	Ion_trans_2	<191..247	CDD:285168	27/55 (49%)
CG1688	NP_610516.1	Ion_trans_2	822..896	CDD:285168
KCNK17	NP_113648.2	Ion_trans_2	96..157	CDD:285168	28/70 (40%)
		Ion_trans_2	<203..268	CDD:285168
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	287..312
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000030
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11003
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.910