DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1688 and CG42340

DIOPT Version :9

Sequence 1:	NP_610516.1	Gene:	CG1688 / 36005	FlyBaseID:	FBgn0027589	Length:	918	Species:	Drosophila melanogaster
Sequence 2:	NP_001368973.1	Gene:	CG42340 / 7354472	FlyBaseID:	FBgn0259242	Length:	759	Species:	Drosophila melanogaster

Alignment Length:	849	Identity:	197/849 - (23%)
Similarity:	281/849 - (33%)	Gaps:	356/849 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 GGVGGAGCGSEMGAKTTASLTAKPRSSLRRCCGHLLKLLFSTPGLVLLVIGYSVLGGLLFPLLEA 99
            ||.||:.||.:...|:             .|        .|..|::|||:.|:.:|.::|..||.
  Fly    76 GGGGGSLCGCQKAPKS-------------HC--------ISATGVLLLVLLYTAMGSIVFVTLEG 119

  Fly   100 PQD----------ISK-----SAAIAKSREDCLRELWIITEKLNVLYERNWTMLVHEQLRRFEGS 149
            ..:          .||     ..|.|:.|...:..||.|||.||:||:.|||.|..::::.|:.:
  Fly   120 ELEDGGALETAVAASKPYPRTELANAEIRSRTVDRLWSITEDLNILYKENWTRLAAQEVQLFQDT 184

  Fly   150 IVAATRQGSAGSSGGGGAGLFHEGSASALGHFGYDAGDSQSWSFSEALLYSVTVITTIGHGSLTP 214
            ::.|.||......||        ...:|..|         .|:::.|.|||:|:|||||:|.::|
  Fly   185 LLRAVRQSKVYPPGG--------IQLNAPTH---------KWTYASAFLYSLTLITTIGYGGISP 232

  Fly   215 RTAAGKLATIFYALVGVPLMLMCLSSLGALLADGLQCTYVRLCCQLQRHQEHRRKSTPGTSTPSA 279
            ||..|::|.:.|||.|:|::|:.||::|..|:.|::|.:.|          .|.|..||......
  Fly   233 RTQWGRVAALVYALFGIPIVLLYLSAMGEALSAGMRCLFRR----------QRVKGGPGGGPGGG 287

  Fly   280 SS-------AANSREKDTDKRSKRRMANCKGCQYDAANSETSLNDCLEYGQKGKLPPDKKEGDAC 337
            :|       ..:...:.|||.        ||   ........|:   :||    |||.
  Fly   288 ASGGVGSGAGGSGGGRKTDKN--------KG---QGHYGHQKLH---QYG----LPPS------- 327

  Fly   338 QLLRNLNPQQHFYQQQQ-QQPQQPDVMLMTTTSGSALLKYAPQQQQLQQQQQLSTATLPRQHHQM 401
                       .||||| ||.||                  .||||.||.|
  Fly   328 -----------VYQQQQAQQAQQ------------------AQQQQAQQAQ-------------- 349

  Fly   402 QLQQQQQQLQQ---------NFVAVPSSMLRMPLTVPPNCYAPATA-------------TIYFPF 444
              |.||||:||         ...:||.|:....|.    ||..:.|             ::||.|
  Fly   350 --QAQQQQVQQGKKSSGNRRGSPSVPISICVCVLL----CYVSSGAILFHKLQNWSVLESLYFCF 408

  Fly   445 ------GHAPSAPG--------------------------------------------------- 452
                  |....||.
  Fly   409 TSLGTIGFGEMAPNGAVALYTASAYILVGMAVVAMCFSLIQTEIVLWLRRFSVQDHVMPKAEELA 473

  Fly   453 ------SPAHNQAHPTQNPN-----GNALGNTTLGSQPLVKYHTIHLQPASGKHRVLASGLQDAT 506
                  :|..: ..|:.:|:     |..|....|| ||         |...|:|:.:..|
  Fly   474 LVTVAVTPKPSXQRPSADPSLGVGLGVGLAGGALG-QP---------QNNLGQHQTMFFG----- 523

  Fly   507 AVNLVTASEASTSTLEAITLPPPPAYQTASVHA----------VRRAKFVAKP-----LPQEINA 556
                    .|.|.| :..:||.....|.|:...          :||:..:.:.     :|:.|:.
  Fly   524 --------PAHTLT-QYSSLPRRSHLQAANNSGGGSAFQRNTPIRRSTGIPEHHLEYFVPRSISE 579

  Fly   557 LMDCGTGSPDLSGRHDL-LPPPHSGSPATGTAASPLLTYTAAATSPQLSAGIKGGSGPAPTAGAP 620
            .        :|||..|| ||||...||..                      :.||.|   ..|..
  Fly   580 F--------NLSGVGDLALPPPRRYSPNM----------------------VGGGGG---MGGMG 611

  Fly   621 MLVSGAGRGAAALTDNGFMAAGVCGMGAAAAPLP-VTSMGAATTTASSAASTLS----------- 673
            |.:.|.|           |..|: |||     || ...:|...|...|||.|:.
  Fly   612 MNMGGMG-----------MNMGM-GMG-----LPHGLQLGPPQTLLCSAAPTVQQQQQPPPPPAQ 659

  Fly   674 ---ALLSANSTGNVDIMEDEDEQE------------RERLSNCPHG---TPSRVPLIASPLSVPQ 720
               ..|...|...| ..|||.:|.            .....:||||   ||.:.|.:..... |.
  Fly   660 LQIVTLKPRSEKMV-TFEDESKQAVGGGAVGGVAGGSGTPPHCPHGVPTTPRKSPAVGDIFMXPG 723

  Fly   721 DSGE 724
            ...|
  Fly   724 AQNE 727

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1688	NP_610516.1	Ion_trans_2	<191..247	CDD:285168	27/55 (49%)
CG1688	NP_610516.1	Ion_trans_2	822..896	CDD:285168
CG42340	NP_001368973.1	Ion_trans_2	<208..264	CDD:400301	26/55 (47%)
CG42340	NP_001368973.1	Ion_trans_2	380..453	CDD:400301	10/76 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461316
Domainoid	1	1.000	51	1.000	Domainoid score	I4317
eggNOG	1	0.900	-	-		E1_KOG1418
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D542195at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11003
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.850