DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG1688 and Kcnd3

DIOPT Version :10

Sequence 1:NP_610516.1 Gene:CG1688 / 36005 FlyBaseID:FBgn0027589 Length:918 Species:Drosophila melanogaster
Sequence 2:NP_064315.1 Gene:Kcnd3 / 56543 MGIID:1928743 Length:655 Species:Mus musculus


Alignment Length:598 Identity:123/598 - (20%)
Similarity:194/598 - (32%) Gaps:190/598 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    42 CGSEMGAKTTASLTAKPRSSLRRCCGHLLKLLF---STPGLVLLVIGYSVLGGLLFPLLEAPQDI 103
            ||:..|:|...             ||....:.|   .|..:::..:.|      |..|..||   
Mouse   207 CGTVPGSKELP-------------CGERYSVAFFCLDTACVMIFTVEY------LLRLFAAP--- 249

  Fly   104 SKSAAIAKSREDCLRELWIITEKLNVL-YERNWTMLVHEQ-------LRRFEGSIVAATRQGSAG 160
                    ||...:|.:..|.:.:.:: |.....|..:|.       ||.|.   |....:.|..
Mouse   250 --------SRYRFIRSVMSIIDVVAIMPYYIGLVMTNNEDVSGAFVTLRVFR---VFRIFKFSRH 303

  Fly   161 SSGGGGAGLFHEGSASALGH----------------FGYDAGDSQS--WSFSEALLYSVTVITTI 207
            |.|....|...:..||.||.                |..:.|.|.|  .|...:..|::..:||:
Mouse   304 SQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPASFWYTIVTMTTL 368

  Fly   208 GHGSLTPRTAAGKLATIFYALVGVPLMLMCLSSLGALLADGLQCTYVRLCCQLQRHQEHRRKSTP 272
            |:|.:.|:|.|||:.....:|.||.::        ||....:...:.|:..|.||..:.|     
Mouse   369 GYGDMVPKTIAGKIFGSICSLSGVLVI--------ALPVPVIVSNFSRIYHQNQRADKRR----- 420

  Fly   273 GTSTPSASSAANSREKDTDKRSKRRMANCKGCQYDAANS------ETSLNDCLEYGQKGKLPPDK 331
                               .:.|.|:|..:..:..::|:      ...||:.||.   ...|.::
Mouse   421 -------------------AQKKARLARIRVAKTGSSNAYLHSKRNGLLNEALEL---TGTPEEE 463

  Fly   332 KEGDACQLLRNLNPQQHFYQQQQQQPQQPDVMLMTTTSGSALLKYAPQQQQLQQQQQLSTATLPR 396
            :.|....|:.:    ||.:.          :..:..|:|   |.|      |.....||..|...
Mouse   464 QMGKTTSLIES----QHHHL----------LHCLEKTTG---LSY------LVDDPLLSVRTSTI 505

  Fly   397 QHHQMQLQQQQQQLQQNFVAVPSSMLRMPLTVPPNCYAPATATIYFPFGHAPSAPGSPAHNQAHP 461
            ::|:.   ..:|..:||  .:.|||...|.|..|:..:           |:.......:......
Mouse   506 KNHEF---IDEQMFEQN--CMESSMQNYPSTRSPSLSS-----------HSGLTTTCCSRRSKKT 554

  Fly   462 TQNPNGNALGNTTLGSQPLVKYHTIHL----QPASGKHRVLASGLQDATAVNLVTASEASTSTLE 522
            |..||.| |..|.|.|  :.:..|:|:    ||:....|   |.|.......|....:.|..|..
Mouse   555 THLPNSN-LPATRLRS--MQELSTLHIQGSEQPSLTTSR---SSLNLKADDGLRPNCKTSQITTA 613

  Fly   523 AITLPPPPAYQTASVHAVRRAKFVAKPLPQEINALMDCGTGSPDLSGRHDLLPPPHSGSPATGTA 587
            .|::|.|||.                               :|:...|    |||.|..|.|.. 
Mouse   614 IISIPTPPAL-------------------------------TPEGESR----PPPASPGPNTNI- 642

  Fly   588 ASPLLTYTAAATS 600
              |.:|......|
Mouse   643 --PSITSNVVKVS 653

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG1688NP_610516.1 Ion_trans_2 177..247 CDD:462301 22/87 (25%)
Ion_trans_2 822..896 CDD:462301
Kcnd3NP_064315.1 BTB_POZ_KCND3 6..143 CDD:349726
Interaction with KCNIP1 and KCNIP2. /evidence=ECO:0000250|UniProtKB:Q9UK17 6..21
Interaction with KCNIP1. /evidence=ECO:0000250|UniProtKB:Q9UK17 70..78
Ion_trans 186..412 CDD:459842 53/245 (22%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 367..372 2/4 (50%)
DUF3399 468..563 CDD:463381 26/134 (19%)
Interaction with KCNIP1 and KCNIP2. /evidence=ECO:0000250|UniProtKB:Q9UK17 470..487 3/30 (10%)
Mediates dendritic targeting. /evidence=ECO:0000250|UniProtKB:Q63881 472..487 2/28 (7%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 523..565 12/53 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 615..655 16/77 (21%)
Blue background indicates that the domain is not in the aligned region.

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