DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1688 and kcnk18

DIOPT Version :9

Sequence 1:	NP_610516.1	Gene:	CG1688 / 36005	FlyBaseID:	FBgn0027589	Length:	918	Species:	Drosophila melanogaster
Sequence 2:	NP_001177236.2	Gene:	kcnk18 / 561821	ZFINID:	ZDB-GENE-100405-2	Length:	391	Species:	Danio rerio

Alignment Length:	334	Identity:	77/334 - (23%)
Similarity:	128/334 - (38%)	Gaps:	92/334 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 CGHLLKLLFSTPGLVLLVIGYSVLGGLLFPLLE--APQD--------ISKSAAIAKSREDCLREL 120
            |..|...||....|:|.::.|:|||.|:|..:|  .|::        :.|...|.::..|...:.
Zfish    13 CSTLFWRLFPHVFLILSLVLYAVLGALVFRAIEYTNPRNESEEILSIVQKVMEIVQNHTDASEQK 77

  Fly   121 WIITEKLNVLYERNWTMLVHEQLRRFEGSIVAATRQGSAGSSGGGGAGLFHEGSASALGHFGYDA 185
            .:|.:...:|.:                                                :.|:.
Zfish    78 HLINKAKYILDD------------------------------------------------YCYEK 94

  Fly   186 GDSQSWSFSEALLYSVTVITTIGHGSLTPRTAAGKLATIFYALVGVPLMLMCLSSLGALLADGLQ 250
            .....|:|..:|.:..||.||:|:|.:.|.|:.||:|.:.||:||:||||:.:|.:|.|||..|.
Zfish    95 ERDHGWTFFASLFFCCTVFTTVGYGRIYPLTSKGKVACVLYAMVGIPLMLLVISDVGDLLAVLLS 159

  Fly   251 CTYVRLCCQLQR---HQEHRRKSTPGTST-PSASSAANSREKDTDKRSK---------------- 295
            ..|.||....:|   ||..|.:|...||. |.|       :.|||...|
Zfish   160 KAYTRLNLFFRRWIGHQSWRLQSHEKTSALPQA-------QADTDGTYKFNQDVVVLETTNNQQV 217

  Fly   296 -RRMANCKGCQYDAANSETSLNDCL---EYGQKGKLPPDKKEGDACQLLRNLNPQQHFYQQQQQQ 356
             :..::.:...:...|::...:..:   .:..||.|   .|.....:|.|...|:...:....|:
Zfish   218 IQTRSSIRRGSFQLRNNKEIFDRIIVRESFRIKGTL---SKSCSCPELDRVPTPKDELFNDIGQE 279

  Fly   357 PQQPDVMLM 365
            .:|.||.|:
Zfish   280 MEQLDVPLL 288

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1688	NP_610516.1	Ion_trans_2	<191..247	CDD:285168	26/55 (47%)
CG1688	NP_610516.1	Ion_trans_2	822..896	CDD:285168
kcnk18	NP_001177236.2	Ion_trans_2	<99..154	CDD:285168	24/54 (44%)
kcnk18	NP_001177236.2	Ion_trans_2	292..367	CDD:285168
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D542195at33208
OrthoFinder	1	1.000	-	-		FOG0000030
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11003
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	7	6.880