Protein Alignment CG1688 and KCNK9

DIOPT Version :10

• Sequence 1: NP_610516.1
• Gene: CG1688 / 36005
• FlyBaseID: FBgn0027589
• Length: 918
• Species: Drosophila melanogaster
• Sequence 2: NP_001269463.1
• Gene: KCNK9 / 51305
• HGNCID: 6283
• Length: 374
• Species: Homo sapiens
• Alignment Length: 193
• Identity: 46/193 - (23%)
• Similarity: 81/193 - (41%)
• Gaps: 57/193 - (29%)

  Fly    76 TPGLVLLVIGYSVLGGLLFPLLEAPQDISKSAAIAKSREDCLRELWIITEKLNVLYERNWTMLVH 140
            |..|::....|.::|..:|..||:..::.:        |:.|:     .|::.:..:.|   :..
Human     8 TLSLIVCTFTYLLVGAAVFDALESDHEMRE--------EEKLK-----AEEIRIKGKYN---ISS 56

  Fly   141 EQLRRFEGSIVAATRQGSAGSSGGGGAGLFHEGSASALGHFGYDAGDSQSWSFSEALLYSVTVIT 205
            |..|:.| .::..:....||                            ..|.|:.:..:::||||
Human    57 EDYRQLE-LVILQSEPHRAG----------------------------VQWKFAGSFYFAITVIT 92

  Fly   206 TIGHGSLTPRTAAGKLATIFYALVGVPLMLMCLSSLGALLADGLQCTYVRL-------CCQLQ 261
            |||:|...|.|.|||...:|||::|:||.|:...|||..:.     |:||.       ||.::
Human    93 TIGYGHAAPGTDAGKAFCMFYAVLGIPLTLVMFQSLGERMN-----TFVRYLLKRIKKCCGMR 150

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1688	NP_610516.1	Ion_trans_2	177..247	CDD:462301	25/69 (36%)
		Ion_trans_2	822..896	CDD:462301
KCNK9	NP_001269463.1	Ion_trans_2	<73..132	CDD:462301	27/86 (31%)
		Selectivity filter 1. /evidence=ECO:0000305|PubMed:26919430	93..98		3/4 (75%)
		Ion_trans_2	<183..243	CDD:462301
		Selectivity filter 2. /evidence=ECO:0000305|PubMed:26919430	199..204
		X-gate. /evidence=ECO:0000269|PubMed:38630723	243..248