Protein Alignment CG1688 and KCNK4

DIOPT Version :10

• Sequence 1: NP_610516.1
• Gene: CG1688 / 36005
• FlyBaseID: FBgn0027589
• Length: 918
• Species: Drosophila melanogaster
• Sequence 2: NP_201567.1
• Gene: KCNK4 / 50801
• HGNCID: 6279
• Length: 393
• Species: Homo sapiens
• Alignment Length: 172
• Identity: 52/172 - (30%)
• Similarity: 77/172 - (44%)
• Gaps: 33/172 - (19%)

  Fly    79 LVLLVIGYSVLGGLLFPLLEAPQDISKSAAIAKSREDCLRELWIITEKLNVLYERNWTMLVHEQL 143
            |:.||:.|.|.|.|:|..||.|.:......:.:.||..||....::       ::...:|:.|
Human     9 LLALVLLYLVSGALVFRALEQPHEQQAQRELGEVREKFLRAHPCVS-------DQELGLLIKE-- 64

  Fly   144 RRFEGSIVAATRQGSAGSSGGGGAGLFHEGSASALGHFGYDAGDSQSWSFSEALLYSVTVITTIG 208
                           ...:.||||.. ...|.|...|        .:|....|..:|.|:|||||
Human    65 ---------------VADALGGGADP-ETNSTSNSSH--------SAWDLGSAFFFSGTIITTIG 105

  Fly   209 HGSLTPRTAAGKLATIFYALVGVPLMLMCLSSLGALLADGLQ 250
            :|::..||.||:|..|||||||:||..:.|:.:|..|...|:
Human   106 YGNVALRTDAGRLFCIFYALVGIPLFGILLAGVGDRLGSSLR 147

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1688	NP_610516.1	Ion_trans_2	177..247	CDD:462301	28/69 (41%)
		Ion_trans_2	822..896	CDD:462301
KCNK4	NP_201567.1	Ion_trans_2	<88..142	CDD:462301	26/53 (49%)
		Selectivity filter 1. /evidence=ECO:0000269|PubMed:22282805, ECO:0000269|PubMed:23341632, ECO:0000269|PubMed:25471887, ECO:0000269|PubMed:25500157	103..108		3/4 (75%)
		Ion_trans_2	180..258	CDD:462301
		Selectivity filter 2. /evidence=ECO:0000269|PubMed:22282805, ECO:0000269|PubMed:23341632, ECO:0000269|PubMed:25471887, ECO:0000269|PubMed:25500157	212..217
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	285..393