DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1688 and Kcnk18

DIOPT Version :9

Sequence 1:	NP_610516.1	Gene:	CG1688 / 36005	FlyBaseID:	FBgn0027589	Length:	918	Species:	Drosophila melanogaster
Sequence 2:	NP_001003820.1	Gene:	Kcnk18 / 445371	RGDID:	1303091	Length:	405	Species:	Rattus norvegicus

Alignment Length:	405	Identity:	94/405 - (23%)
Similarity:	145/405 - (35%)	Gaps:	147/405 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 IKAKQPQPSQLDCSIDDETDATEFGGLGGVGGAGCGSEMGAKTTASLTAKPRSSLRRCCGHLL-K 71
            ::|::|..::..|.          ..||  ..:||..|...|.            |.||...| |
  Rat     1 MEAEEPPEARRRCP----------EALG--KASGCCPEAPGKA------------RGCCPEALGK 41

  Fly    72 LLFSTPGLVLL--VIGYSVLGGLLFPLLEAPQDISKSAAIAKSREDCLRELWIITEKLNVLYERN 134
            ||   |||..|  ::.|:::|..||..:|...|       .::.|:  .||....:||..:.:.|
  Rat    42 LL---PGLCFLCCLVTYALVGAALFSAVEGRPD-------PEAEEN--PELKKFLDKLCNILKCN 94

  Fly   135 WTML------VHEQLRRFEGSIVAATRQGSAGSSGGGGAGLFHEGSASALGHFGYDAGDSQSWSF 193
            .|::      :.|.|::.:.....|                                  .:.|||
  Rat    95 LTVVEGSRKDLCEHLQQLKPQWFKA----------------------------------PEDWSF 125

  Fly   194 SEALLYSVTVITTIGHGSLTPRTAAGKLATIFYALVGVPLMLMCLSSLGALLADGLQCTYVR--- 255
            ..||.:..||.:|:|:|.:.|.|..||...:.|||.|:|||.:.|:.:|.:||..|...|.|
  Rat   126 LSALFFCCTVFSTVGYGHMYPVTRLGKFLCMLYALFGIPLMFLVLTDIGDILAAILSRAYSRFQA 190

  Fly   256 LCCQLQRHQEHR-----RKST-----------------------PGTSTPSASSAAN-------- 284
            |.|..:...:.|     ||.|                       |..|...||.:.|
  Rat   191 LLCLPRDISKWRPLLLCRKQTDSKPADEAIPQIVIDAGADELLDPQPSREPASPSCNVELFERLV 255

  Fly   285 SREKDTDKRSKRRMANCKGCQYDAANSETSLNDCLEYGQKGKLPPDKKEGDACQLLRNLNPQQHF 349
            :|||..:.:...|..            |.| |.|.|. ..|:|        :|.:|.||:
  Rat   256 AREKQNELQPPMRPV------------ERS-NSCPEL-VLGRL--------SCSILSNLD----- 293

  Fly   350 YQQQQQQPQQPDVML 364
              :..||.::.|:.|
  Rat   294 --EVGQQVERLDIPL 306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1688	NP_610516.1	Ion_trans_2	<191..247	CDD:285168	24/55 (44%)
CG1688	NP_610516.1	Ion_trans_2	822..896	CDD:285168
Kcnk18	NP_001003820.1	Ion_trans_2	116..177	CDD:285168	24/94 (26%)
		Interaction with calcineurin. /evidence=ECO:0000250	221..226		0/4 (0%)
		Interaction with YWHAH. /evidence=ECO:0000250	272..277		2/5 (40%)
		Ion_trans_2	311..387	CDD:285168
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D542195at33208
OrthoFinder	1	1.000	-	-		FOG0000030
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11003
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.970