DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG1688 and KCNQ2

DIOPT Version :9

Sequence 1:NP_610516.1 Gene:CG1688 / 36005 FlyBaseID:FBgn0027589 Length:918 Species:Drosophila melanogaster
Sequence 2:NP_001369164.1 Gene:KCNQ2 / 3785 HGNCID:6296 Length:890 Species:Homo sapiens


Alignment Length:847 Identity:161/847 - (19%)
Similarity:258/847 - (30%) Gaps:322/847 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    27 DATEFGGLGGVGGAGCGSEMGAKTTASLTAKPRSS-------------LRRCCGHLLKLLFSTPG 78
            |:|..|.|     ...|||  |....|:.:|||:.             .|:....|..:|....|
Human    33 DSTRDGAL-----LIAGSE--APKRGSILSKPRAGGAGAGKPPKRNAFYRKLQNFLYNVLERPRG 90

  Fly    79 LVLLVIGYSVLGGLLFPLLEAPQDISKSAAI---AKSREDCLRELWIITEKLNVL----YERNWT 136
            ...:...|..|  |:|..|.    :|..:.|   .||.|..|..|.|:|  :.|.    :.|.|.
Human    91 WAFIYHAYVFL--LVFSCLV----LSVFSTIKEYEKSSEGALYILEIVT--IVVFGVEYFVRIWA 147

  Fly   137 MLVHEQLRRFEG---------------------SIVAATRQGSAGSS------------------ 162
            .....:.|.:.|                     :::||..||:..::                  
Human   148 AGCCCRYRGWRGRLKFARKPFCVIDIMVLIASIAVLAAGSQGNVFATSALRSLRFLQILRMIRMD 212

  Fly   163 --GG-----GGAGLFHEGSASALGHFGY-------------DAGDSQSW-SFSEALLYSVTVITT 206
              ||     |.....|........:.|:             :.|::..: ::::||.:.:..:||
Human   213 RRGGTWKLLGSVVYAHSKELVTAWYIGFLCLILASFLVYLAEKGENDHFDTYADALWWGLITLTT 277

  Fly   207 IGHGSLTPRTAAGKLATIFYALVGVPLMLMCLSSLGALLADGLQCTYVRLCCQLQRHQEHRRKST 271
            ||:|...|:|..|:|....:.|:||....:....||:..|             |:..::||:|..
Human   278 IGYGDKYPQTWNGRLLAATFTLIGVSFFALPAGILGSGFA-------------LKVQEQHRQKHF 329

  Fly   272 PGTSTPSASSAANSREKDTDKRSKRRMANCKGCQYDAAN-SETSLNDCLE--------------- 320
            .....|:|....::                  .::.|.| |.|.|:...:               
Human   330 EKRRNPAAGLIQSA------------------WRFYATNLSRTDLHSTWQYYERTVTVPMYSSQT 376

  Fly   321 --YGQKGKLPPDKKEGDACQLLRNLNPQQHFYQQQQQQPQQPDVMLMTTTSGSALLKYAPQQQQL 383
              ||....:||..:    .:|||||.                      :.||.|..|..|.:   
Human   377 QTYGASRLIPPLNQ----LELLRNLK----------------------SKSGLAFRKDPPPE--- 412

  Fly   384 QQQQQLSTATLPRQHHQMQLQQQQQQLQQNFVAVPSSMLRMPLTVPPNCYAPATATIYFPFGHAP 448
                       |....::.|:.:          |.||                      |.|.|.
Human   413 -----------PSPSQKVSLKDR----------VFSS----------------------PRGVAA 434

  Fly   449 SAPGSPAHNQAH---------------PTQNPNGNALGNTTLGSQPLVKYHTIHLQPASGKHRVL 498
            ...|||   ||.               |::.|...:.|:.:...|      ...::.|:.:....
Human   435 KGKGSP---QAQTVRRSPSADQSLEDSPSKVPKSWSFGDRSRARQ------AFRIKGAASRQNSE 490

  Fly   499 ASGLQDATAVNLVTASEASTSTLEAITLPPPPAYQTASVHA-------VRRAKFVAKPLPQEI-N 555
            .:.|.....|      :..:...|.:|....|..: .|:.|       |.:.||.....|.:: :
Human   491 EASLPGEDIV------DDKSCPCEFVTEDLTPGLK-VSIRAVCVMRFLVSKRKFKESLRPYDVMD 548

  Fly   556 ALMDCGTGSPD-------LSGRHDLL---PPP----HSGSPATGTAASPLLTYTAAATSPQLSAG 606
            .:.....|..|       |..|.|::   |||    |...|..|..|.|       ..|||.|  
Human   549 VIEQYSAGHLDMLSRIKSLQSRIDMIVGPPPPSTPRHKKYPTKGPTAPP-------RESPQYS-- 604

  Fly   607 IKGGSGPAPTAGAPMLVSGAGRGAAALTDNGFMAAGVCGMGAAAAPLP-----VTSMGAATTTAS 666
                         |.:....||| .|:||....      .|.|.|.||     :..:|.......
Human   605 -------------PRVDQIVGRG-PAITDKDRT------KGPAEAELPEDPSMMGRLGKVEKQVL 649

  Fly   667 SAASTLSALLSANSTGNVDIMEDEDEQERERLSNCPHGTP----SRVPLIASPLSVPQDSGENTT 727
            |....|..|:      |:.:         :|:...|..|.    ::.|..|.|...|:||.|:..
Human   650 SMEKKLDFLV------NIYM---------QRMGIPPTETEAYFGAKEPEPAPPYHSPEDSREHVD 699

  Fly   728 RN 729
            |:
Human   700 RH 701

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG1688NP_610516.1 Ion_trans_2 <191..247 CDD:285168 16/56 (29%)
Ion_trans_2 822..896 CDD:285168
KCNQ2NP_001369164.1 Ion_trans 92..324 CDD:395416 47/252 (19%)
KCNQ_channel 448..669 CDD:397540 51/277 (18%)
KCNQ2_u3 684..774 CDD:406935 7/18 (39%)
KCNQC3-Ank-G_bd 786..886 CDD:403240
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D774951at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.010

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