Protein Alignment CG1688 and KCNK3

DIOPT Version :10

• Sequence 1: NP_610516.1
• Gene: CG1688 / 36005
• FlyBaseID: FBgn0027589
• Length: 918
• Species: Drosophila melanogaster
• Sequence 2: NP_002237.1
• Gene: KCNK3 / 3777
• HGNCID: 6278
• Length: 394
• Species: Homo sapiens
• Alignment Length: 207
• Identity: 53/207 - (25%)
• Similarity: 84/207 - (40%)
• Gaps: 57/207 - (27%)

  Fly    76 TPGLVLLVIGYSVLGGLLFPLLEAPQDISKSAAIAKSREDCLRELWIITEKLNVLYERNWTMLVH 140
            |..|::....|.::|..:|..||:..::     |.:.|.: ||:     ::|...|  |.:...:
Human     8 TLALIVCTFTYLLVGAAVFDALESEPEL-----IERQRLE-LRQ-----QELRARY--NLSQGGY 59

  Fly   141 EQLRRFEGSIVAATRQGSAGSSGGGGAGLFHEGSASALGHFGYDAGDSQSWSFSEALLYSVTVIT 205
            |:|.|    :|...:...||                            ..|.|:.:..:::||||
Human    60 EELER----VVLRLKPHKAG----------------------------VQWRFAGSFYFAITVIT 92

  Fly   206 TIGHGSLTPRTAAGKLATIFYALVGVPLMLMCLSSLGALLADGLQCTYVRLCCQLQRHQEHRRKS 270
            |||:|...|.|..||:..:||||:|:||.|:...|||..:.            .|.|:..||.|.
Human    93 TIGYGHAAPSTDGGKVFCMFYALLGIPLTLVMFQSLGERIN------------TLVRYLLHRAKK 145

  Fly   271 TPGTSTPSASSA 282
            ..|......|.|
Human   146 GLGMRRADVSMA 157

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1688	NP_610516.1	Ion_trans_2	177..247	CDD:462301	25/69 (36%)
		Ion_trans_2	822..896	CDD:462301
KCNK3	NP_002237.1	Ion_trans_2	<73..132	CDD:462301	27/86 (31%)
		Selectivity filter 1. /evidence=ECO:0000305|PubMed:26919430	93..98		3/4 (75%)
		Ion_trans_2	167..243	CDD:462301
		Selectivity filter 2. /evidence=ECO:0000305|PubMed:26919430	199..204
		X-gate. /evidence=ECO:0000269|PubMed:32499642	243..248
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	266..286
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	338..357