DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1688 and KCNK2

DIOPT Version :9

Sequence 1:	NP_610516.1	Gene:	CG1688 / 36005	FlyBaseID:	FBgn0027589	Length:	918	Species:	Drosophila melanogaster
Sequence 2:	NP_001017425.2	Gene:	KCNK2 / 3776	HGNCID:	6277	Length:	426	Species:	Homo sapiens

Alignment Length:	242	Identity:	59/242 - (24%)
Similarity:	95/242 - (39%)	Gaps:	91/242 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 TASLTAKPRSSLRRCCGHLLKLLFSTPGLV-----------------------LLVIGYSVLGGL 92
            :|:..:|||            |.|||...|                       |:|:.|.::|..
Human    26 SAAQNSKPR------------LSFSTKPTVLASRVESDTTINVMKWKTVSTIFLVVVLYLIIGAT 78

  Fly    93 LFPLLEAPQDISKSAAIA------KSREDCLRELWIITEKLNVLYERNWTMLVHEQLRRFEGSIV 151
            :|..||.|.:||:...|.      .|:..|:.     :.:|:.|.::                ||
Human    79 VFKALEQPHEISQRTTIVIQKQTFISQHSCVN-----STELDELIQQ----------------IV 122

  Fly   152 AATRQGSAGSSGGGGAGLFHEGSAS-ALGHFGYDAGDSQSWSFSEALLYSVTVITTIGHGSLTPR 215
            ||.           .||:...|:.| .:.|          |....:..::.|||||||.|:::||
Human   123 AAI-----------NAGIIPLGNTSNQISH----------WDLGSSFFFAGTVITTIGFGNISPR 166

  Fly   216 TAAGKLATIFYALVGVPLMLMCLS----SLGALLADGL---QCTYVR 255
            |..||:..|.|||:|:||....|:    .||.:...|:   :.|:::
Human   167 TEGGKIFCIIYALLGIPLFGFLLAGVGDQLGTIFGKGIAKVEDTFIK 213

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1688	NP_610516.1	Ion_trans_2	<191..247	CDD:285168	24/59 (41%)
CG1688	NP_610516.1	Ion_trans_2	822..896	CDD:285168
KCNK2	NP_001017425.2	Ion_trans_2	<142..196	CDD:400301	22/53 (42%)
		Ion_trans_2	234..312	CDD:400301
		Required for basal channel activity. /evidence=ECO:0000250	354..426
		Essential for chloroform and halothane sensitivity. /evidence=ECO:0000250	378..426
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	66	1.000	Domainoid score	I9913
eggNOG	1	0.900	-	-		E1_KOG1418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000030
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11003
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.910