DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1688 and KCNK1

DIOPT Version :9

Sequence 1:	NP_610516.1	Gene:	CG1688 / 36005	FlyBaseID:	FBgn0027589	Length:	918	Species:	Drosophila melanogaster
Sequence 2:	NP_002236.1	Gene:	KCNK1 / 3775	HGNCID:	6272	Length:	336	Species:	Homo sapiens

Alignment Length:	209	Identity:	52/209 - (24%)
Similarity:	84/209 - (40%)	Gaps:	59/209 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 LGGVGGAGCGSEMGAKTTASLTAKPRSSLRRCCGHLLKLLFSTPGLVLLVIGYSVLGGLLFPLLE 98
            |..:.|:.|         ..|..:.||:.  |.|.          |||..:.|.|.|.::|..:|
Human     2 LQSLAGSSC---------VRLVERHRSAW--CFGF----------LVLGYLLYLVFGAVVFSSVE 45

  Fly    99 APQDISKSAAIAKSREDCLR-ELWIITEKLNVLYERNWTMLVHEQLRRFEGSIVAATRQGSAGSS 162
            .|.            ||.|| ||    .||...:......|..:||.:|.|.::.|:..|.:..|
Human    46 LPY------------EDLLRQEL----RKLKRRFLEEHECLSEQQLEQFLGRVLEASNYGVSVLS 94

  Fly   163 GGGGAGLFHEGSASALGHFGYDAGDSQSWSFSEALLYSVTVITTIGHGSLTPRTAAGKLATIFYA 227
            ...|                     :.:|.|:.||.::.||::|.|:|...|.:..||...|.|:
Human    95 NASG---------------------NWNWDFTSALFFASTVLSTTGYGHTVPLSDGGKAFCIIYS 138

  Fly   228 LVGVPLMLMCLSSL 241
            ::|:|..|:.|:::
Human   139 VIGIPFTLLFLTAV 152

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1688	NP_610516.1	Ion_trans_2	<191..247	CDD:285168	18/51 (35%)
CG1688	NP_610516.1	Ion_trans_2	822..896	CDD:285168
KCNK1	NP_002236.1	Ion_trans_2	<101..157	CDD:400301	18/52 (35%)
		pore-forming domain	107..123		7/15 (47%)
		Ion_trans_2	192..267	CDD:400301
		pore-forming domain	212..238
		Important for intracellular retention in recycling endosomes. /evidence=ECO:0000269\|PubMed:19959478	293..299
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	57	1.000	Domainoid score	I10857
eggNOG	1	0.900	-	-		E1_KOG1418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	121	1.000	Inparanoid score	I4753
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000030
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.860