DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG1688 and KCND3

DIOPT Version :10

Sequence 1:NP_610516.1 Gene:CG1688 / 36005 FlyBaseID:FBgn0027589 Length:918 Species:Drosophila melanogaster
Sequence 2:NP_004971.2 Gene:KCND3 / 3752 HGNCID:6239 Length:655 Species:Homo sapiens


Alignment Length:600 Identity:126/600 - (21%)
Similarity:196/600 - (32%) Gaps:197/600 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    42 CGSEMGAKTTASLTAKPRSSLRRCCGHLLKLLF---STPGLVLLVIGYSVLGGLLFPLLEAPQDI 103
            ||:..|:|...             ||....:.|   .|..:::..:.|      |..|..||   
Human   207 CGTVPGSKELP-------------CGERYSVAFFCLDTACVMIFTVEY------LLRLFAAP--- 249

  Fly   104 SKSAAIAKSREDCLRELWIITEKLNVL-YERNWTMLVHEQ-------LRRFEGSIVAATRQGSAG 160
                    ||...:|.:..|.:.:.:: |.....|..:|.       ||.|.   |....:.|..
Human   250 --------SRYRFIRSVMSIIDVVAIMPYYIGLVMTNNEDVSGAFVTLRVFR---VFRIFKFSRH 303

  Fly   161 SSGGGGAGLFHEGSASALGH----------------FGYDAGDSQS--WSFSEALLYSVTVITTI 207
            |.|....|...:..||.||.                |..:.|.|.|  .|...:..|::..:||:
Human   304 SQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPASFWYTIVTMTTL 368

  Fly   208 GHGSLTPRTAAGKLATIFYALVGVPLMLMCLSSLGALLADGLQCTYVRLCCQLQRHQEHRRKSTP 272
            |:|.:.|:|.|||:.....:|.||.::        ||....:...:.|:..|.||..:.|     
Human   369 GYGDMVPKTIAGKIFGSICSLSGVLVI--------ALPVPVIVSNFSRIYHQNQRADKRR----- 420

  Fly   273 GTSTPSASSAANSREKDTDKRSKRRMANCKGCQYDAANS------ETSLNDCLEYGQKGKLPPDK 331
                               .:.|.|:|..:..:..::|:      ...||:.||.   ...|.::
Human   421 -------------------AQKKARLARIRVAKTGSSNAYLHSKRNGLLNEALEL---TGTPEEE 463

  Fly   332 KEGDACQLLRNLNPQQHFYQQQQQQPQQPDVMLMTTTSGSALLKYAPQQQQLQQQQQLSTATLPR 396
            ..|....|:.:    ||.:.          :..:..|:|   |.|      |.....||..|...
Human   464 HMGKTTSLIES----QHHHL----------LHCLEKTTG---LSY------LVDDPLLSVRTSTI 505

  Fly   397 QHHQMQLQQQQQQLQQNFVAVPSSMLRMPLTVPPNCYAPATATIYFPFGHAPSAPGSP----AHN 457
            ::|:.   ..:|..:||  .:.|||...|.|..|:               ..|.||..    :..
Human   506 KNHEF---IDEQMFEQN--CMESSMQNYPSTRSPS---------------LSSHPGLTTTCCSRR 550

  Fly   458 QAHPTQNPNGNALGNTTLGSQPLVKYHTIHL----QPASGKHRVLASGLQDATAVNLVTASEAST 518
            ....|..||.| |..|.|.|  :.:..|||:    ||:....|   |.|.......|....:.|.
Human   551 SKKTTHLPNSN-LPATRLRS--MQELSTIHIQGSEQPSLTTSR---SSLNLKADDGLRPNCKTSQ 609

  Fly   519 STLEAITLPPPPAYQTASVHAVRRAKFVAKPLPQEINALMDCGTGSPDLSGRHDLLPPPHSGSPA 583
            .|...|::|.|||.                               :|:...|    |||.|..|.
Human   610 ITTAIISIPTPPAL-------------------------------TPEGESR----PPPASPGPN 639

  Fly   584 TG--TAASPLLTYTA 596
            |.  :.||.::..:|
Human   640 TNIPSIASNVVKVSA 654

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG1688NP_610516.1 Ion_trans_2 177..247 CDD:462301 22/87 (25%)
Ion_trans_2 822..896 CDD:462301
KCND3NP_004971.2 BTB_POZ_KCND3 6..143 CDD:349726
Interaction with KCNIP1 and KCNIP2. /evidence=ECO:0000269|PubMed:17187064, ECO:0000269|PubMed:34997220 6..21
Interaction with KCNIP1. /evidence=ECO:0000269|PubMed:17187064 70..78
Ion_trans 186..412 CDD:459842 53/245 (22%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 367..372 2/4 (50%)
DUF3399 468..563 CDD:463381 28/138 (20%)
Interaction with KCNIP1 and KCNIP2. /evidence=ECO:0000269|PubMed:34997220 470..487 3/30 (10%)
Mediates dendritic targeting. /evidence=ECO:0000250|UniProtKB:Q63881 472..487 2/28 (7%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 525..565 12/55 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 615..655 15/74 (20%)
Blue background indicates that the domain is not in the aligned region.

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