Protein Alignment CG1688 and KCND2

DIOPT Version :10

• Sequence 1: NP_610516.1
• Gene: CG1688 / 36005
• FlyBaseID: FBgn0027589
• Length: 918
• Species: Drosophila melanogaster
• Sequence 2: NP_036413.1
• Gene: KCND2 / 3751
• HGNCID: 6238
• Length: 630
• Species: Homo sapiens
• Alignment Length: 532
• Identity: 110/532 - (20%)
• Similarity: 171/532 - (32%)
• Gaps: 179/532 - (33%)

  Fly    42 CGSEMGAKTTASLTAKPRSSLRRCCGHLLKLLF---STPGLVLLVIGYSVLGGLLFPLLEAPQDI 103
            |||..|     .:...|       ||....:.|   .|..:::..:.|      |..|..||
Human   209 CGSSPG-----HIKELP-------CGERYAVAFFCLDTACVMIFTVEY------LLRLAAAP--- 252

  Fly   104 SKSAAIAKSREDCLRELWIITEKLNVL-YERNWTMLVHEQ-------LRRFEGSIVAATRQGSAG 160
                    ||...:|.:..|.:.:.:| |.....|..:|.       ||.|.   |....:.|..
Human   253 --------SRYRFVRSVMSIIDVVAILPYYIGLVMTDNEDVSGAFVTLRVFR---VFRIFKFSRH 306

  Fly   161 SSGGGGAGLFHEGSASALGH----------------FGYDAGDSQS--WSFSEALLYSVTVITTI 207
            |.|....|...:..||.||.                |..:.|.|.|  .|...|..|::..:||:
Human   307 SQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPAAFWYTIVTMTTL 371

  Fly   208 GHGSLTPRTAAGKLATIFYALVGVPLMLMCLSSLGALLADGLQCTYVRLCCQLQRHQEHRRKSTP 272
            |:|.:.|:|.|||:.....:|.||.::        ||....:...:.|:..|.||..:.|
Human   372 GYGDMVPKTIAGKIFGSICSLSGVLVI--------ALPVPVIVSNFSRIYHQNQRADKRR----- 423

  Fly   273 GTSTPSASSAANSREKDTDKRSKRRMANCKGCQYDAANSETSLNDCLEYGQKGKLPPDKKEGDAC 337
                               .:.|.|:|..:..:..:||:         |.|      .|:.|
Human   424 -------------------AQKKARLARIRAAKSGSANA---------YMQ------SKRNG--- 451

  Fly   338 QLLRNLNPQQHFYQQQQQQPQQPDVMLMTTTSGSALLKYAPQQQQLQQQQQLSTATLPRQHHQMQ 402
             ||.|        |.|..:.:|..|    :.|||                     :...|||.:
Human   452 -LLSN--------QLQSSEDEQAFV----SKSGS---------------------SFETQHHHL- 481

  Fly   403 LQQQQQQLQQNFV---AVPSSMLRMPLTVPPNCYAPATATIYFPFGHAPSAPG---------SPA 455
            |...::.....||   ....|.:.:             ||:..|..|:||...         |..
Human   482 LHCLEKTTNHEFVDEQVFEESCMEV-------------ATVNRPSSHSPSLSSQQGVTSTCCSRR 533

  Fly   456 HNQAHPTQNPNGNALGNTTLGSQPL--VKYHTIHLQPASGKHRVLASGLQDATAVNLVTASEAST 518
            |.:..  :.||.|..|:.....|.|  ::...:...|.|.....|.:.:::...:|    .|...
Human   534 HKKTF--RIPNANVSGSHQGSIQELSTIQIRCVERTPLSNSRSSLNAKMEECVKLN----CEQPY 592

  Fly   519 STLEAITLPPPP 530
            .|...|::|.||
Human   593 VTTAIISIPTPP 604

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1688	NP_610516.1	Ion_trans_2	177..247	CDD:462301	23/87 (26%)
		Ion_trans_2	822..896	CDD:462301
KCND2	NP_036413.1	Interaction with KCNIP1, KCNIP2, and other family members. /evidence=ECO:0000250|UniProtKB:Q63881	2..20
		BTB_POZ	6..144	CDD:453885
		Interaction with KCNIP1. /evidence=ECO:0000250|UniProtKB:Q63881	71..90
		Ion_trans	184..415	CDD:459842	56/245 (23%)
		S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142	308..321		2/12 (17%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	370..375		2/4 (50%)
		DUF3399	470..546	CDD:463381	21/112 (19%)
		Important for normal channel activation and inactivation, for interaction with KCNIP2, and probably other family members as well. /evidence=ECO:0000250|UniProtKB:Q63881, ECO:0000305|PubMed:16934482	474..630		31/151 (21%)
		Required for dendritic targeting. /evidence=ECO:0000250|UniProtKB:Q63881	474..489		4/15 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	600..630		3/5 (60%)
		PDZ-binding. /evidence=ECO:0000250|UniProtKB:Q63881	627..630