Protein Alignment CG1688 and KCNC1

DIOPT Version :10

• Sequence 1: NP_610516.1
• Gene: CG1688 / 36005
• FlyBaseID: FBgn0027589
• Length: 918
• Species: Drosophila melanogaster
• Sequence 2: NP_001106212.1
• Gene: KCNC1 / 3746
• HGNCID: 6233
• Length: 585
• Species: Homo sapiens
• Alignment Length: 290
• Identity: 59/290 - (20%)
• Similarity: 99/290 - (34%)
• Gaps: 113/290 - (38%)

  Fly    64 RCCGHLLKLLFSTPGLVLLVIGYSVLGGLLFPLLEAPQDISKSAAIAKSREDCLRELWIITEKLN 128
            |..||.|:.  ||...:||:| :..||.|:|.
Human   332 RVLGHTLRA--STNEFLLLII-FLALGVLIFA--------------------------------- 360

  Fly   129 VLYERNWTMLVHEQLRRFEGSIVAATRQGSAGSSGGGGAGLFHEGSASALGHF-----GYDAGDS 188
                   ||:.:            |.|.|:..          ::.|||...||     |:
Human   361 -------TMIYY------------AERIGAQP----------NDPSASEHTHFKNIPIGF----- 391

  Fly   189 QSWSFSEALLYSVTVITTIGHGSLTPRTAAGKLATIFYALVGVPLMLM----CLSSLGALLADGL 249
              |       ::|..:||:|:|.:.|:|.:|.|.....||.||..:.|    .:::.|
Human   392 --W-------WAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFG------- 440

  Fly   250 QCTYVRLCCQLQRHQEHRRK---STPGTSTPS-----ASSAANSREKDTDKRSKRRM-----ANC 301
              .|..|....|:..:.::|   ..|...:|:     .:|..:|.:.||...::..:     |:.
Human   441 --MYYSLAMAKQKLPKKKKKHIPRPPQLGSPNYCKSVVNSPHHSTQSDTCPLAQEEILEINRADS 503

  Fly   302 KGCQYDAANSETSLNDCLEYGQKGKLPPDK 331
            | ...:.|.:..:..||....|  .|.||:
Human   504 K-LNGEVAKAALANEDCPHIDQ--ALTPDE 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1688	NP_610516.1	Ion_trans_2	177..247	CDD:462301	19/78 (24%)
		Ion_trans_2	822..896	CDD:462301
KCNC1	NP_001106212.1	BTB_KCNC1_3	6..122	CDD:349721
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	121..147
		Ion_trans	189..447	CDD:459842	42/202 (21%)
		Selectivity filter. /evidence=ECO:0000250	400..405		2/4 (50%)