DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG1688 and KCNB1

DIOPT Version :10

Sequence 1:NP_610516.1 Gene:CG1688 / 36005 FlyBaseID:FBgn0027589 Length:918 Species:Drosophila melanogaster
Sequence 2:NP_004966.1 Gene:KCNB1 / 3745 HGNCID:6231 Length:858 Species:Homo sapiens


Alignment Length:513 Identity:101/513 - (19%)
Similarity:180/513 - (35%) Gaps:123/513 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   184 DAGDSQSWSFSEALLYSVTVITTIGHGSLTPRTAAGKLATIFYALVGVPLMLMCLSSLGALLADG 248
            |..|::..|...:..::...:||:|:|.:.|:|..||:......:.||.::.:.:    .::.:.
Human   355 DEDDTKFKSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPI----PIIVNN 415

  Fly   249 LQCTYVRLCCQLQRHQE---HRRKSTPGTSTPSASSAANSR--------------EKD------T 290
            ....|     :.|:.||   .||::........:..:.|.:              ||:      .
Human   416 FSEFY-----KEQKRQEKAIKRREALERAKRNGSIVSMNMKDAFARSIEMMDIVVEKNGENMGKK 475

  Fly   291 DKRSKRRMANCKGCQYDAANSETSLNDCLEYGQKGKLPPDKKEGDACQLLRNLNPQQHFYQQQQQ 355
            ||.....::..|........||||.:...|..::|.  |:|....:.....|:...:..|.:..:
Human   476 DKVQDNHLSPNKWKWTKRTLSETSSSKSFETKEQGS--PEKARSSSSPQHLNVQQLEDMYNKMAK 538

  Fly   356 QPQQPDVMLMTTTSGSALLKYAPQQQQLQQQQQLSTATLPRQHHQMQLQQQQQQLQQNFVAVPSS 420
            ...||   ::.|...:|..|  |:::...:......|.||.:...: :..:......:|::..:.
Human   539 TQSQP---ILNTKESAAQSK--PKEELEMESIPSPVAPLPTRTEGV-IDMRSMSSIDSFISCATD 597

  Fly   421 ------MLRMPLTVPPNCYAPATATIYFP--------------FGHAPSAPGSPAHNQAHPTQNP 465
                  ....|||..|:....:||    |              |..|..:|.:..|:... .::|
Human   598 FPEATRFSHSPLTSLPSKTGGSTA----PEVGWRGALGASGGRFVEANPSPDASQHSSFF-IESP 657

  Fly   466 NGNALGNTTL------------GSQPLVKYHTIHLQPA--SGKHRVLASGLQDATAVNLVTASEA 516
            ..:...|..|            ...||:....::..|.  .|......:||:.||.::....|..
Human   658 KSSMKTNNPLKLRALKVNFMEGDPSPLLPVLGMYHDPLRNRGSAAAAVAGLECATLLDKAVLSPE 722

  Fly   517 ST--STLEAITLPPPPAYQTASVHAVRRAKFVAKPLPQEINALMDCGTGSPDLSGR----HDLLP 575
            |:  :|..|.|.|..|...||          :|......::..:|..|   |..|:    .|..|
Human   723 SSIYTTASAKTPPRSPEKHTA----------IAFNFEAGVHQYIDADT---DDEGQLLYSVDSSP 774

  Fly   576 P---PHSGSP--ATGT-------AASPLLTYTAAATSPQL-------SAGIKGGSGPA 614
            |   |.|.||  :|||       .:|||      .|||:.       |.....|.||:
Human   775 PKSLPGSTSPKFSTGTRSEKNHFESSPL------PTSPKFLRQNCIYSTEALTGKGPS 826

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG1688NP_610516.1 Ion_trans_2 177..247 CDD:462301 13/62 (21%)
Ion_trans_2 822..896 CDD:462301
KCNB1NP_004966.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21
BTB_POZ_KCNB2 15..141 CDD:349719
Self-association. /evidence=ECO:0000250|UniProtKB:P15387 59..75
Ion_trans 188..424 CDD:459842 14/77 (18%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 377..382 2/4 (50%)
Self-association. /evidence=ECO:0000250|UniProtKB:P15387 448..481 5/32 (16%)
Kv2channel 467..679 CDD:397541 38/224 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 471..524 11/54 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 538..574 8/40 (20%)
FFAT. /evidence=ECO:0000269|PubMed:33124732 590..596 1/5 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 770..807 15/42 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 836..858
Blue background indicates that the domain is not in the aligned region.

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