Protein Alignment CG1688 and KCNA5

DIOPT Version :10

• Sequence 1: NP_610516.1
• Gene: CG1688 / 36005
• FlyBaseID: FBgn0027589
• Length: 918
• Species: Drosophila melanogaster
• Sequence 2: NP_002225.2
• Gene: KCNA5 / 3741
• HGNCID: 6224
• Length: 613
• Species: Homo sapiens
• Alignment Length: 152
• Identity: 31/152 - (20%)
• Similarity: 60/152 - (39%)
• Gaps: 31/152 - (20%)

  Fly   187 DSQSWSFS---EALLYSVTVITTIGHGSLTPRTAAGKLATIFYALVGVPLMLMCLSSLGALLADG 248
            |:|...||   :|..::|..:||:|:|.:.|.|..||:.....|:.||    :.::....::...
Human   458 DNQGTHFSSIPDAFWWAVVTMTTVGYGDMRPITVGGKIVGSLCAIAGV----LTIALPVPVIVSN 518

  Fly   249 LQCTYVRLCCQLQRHQEHRR----KSTPGTSTPSASSAANSREKDTDKRSKRRMANCKGCQYDAA 309
            ....|       .|..:|..    |...||         .|:....|:..:|:::..:|....|.
Human   519 FNYFY-------HRETDHEEPAVLKEEQGT---------QSQGPGLDRGVQRKVSGSRGSFCKAG 567

  Fly   310 NSETSLNDCLEYGQKGKLPPDK 331
            .:..:.:.    .::|..|.:|
Human   568 GTLENADS----ARRGSCPLEK 585

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1688	NP_610516.1	Ion_trans_2	177..247	CDD:462301	17/62 (27%)
		Ion_trans_2	822..896	CDD:462301
KCNA5	NP_002225.2	Tetramerization domain. /evidence=ECO:0000305|PubMed:20018952	1..211
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..108
		2 X 11 AA tandem repeat of D-[SP]-G-V-R-P-L-P-P-L-P	61..82
		BTB_POZ	120..246	CDD:453885
		Ion_trans	249..526	CDD:459842	18/78 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	282..304
		S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142	418..431
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	480..485		2/4 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	532..559		6/35 (17%)
		PDZ-binding. /evidence=ECO:0000250	611..613