Protein Alignment CG1688 and KCNA4

DIOPT Version :10

• Sequence 1: NP_610516.1
• Gene: CG1688 / 36005
• FlyBaseID: FBgn0027589
• Length: 918
• Species: Drosophila melanogaster
• Sequence 2: NP_002224.1
• Gene: KCNA4 / 3739
• HGNCID: 6222
• Length: 653
• Species: Homo sapiens
• Alignment Length: 142
• Identity: 30/142 - (21%)
• Similarity: 57/142 - (40%)
• Gaps: 23/142 - (16%)

  Fly   192 SFSEALLYSVTVITTIGHGSLTPRTAAGKLATIFYALVGVPLMLMCLSSLGALLADGLQCTYVRL 256
            |..:|..::|..:||:|:|.:.|.|..||:.....|:.||    :.::....::.......|.|
Human   510 SIPDAFWWAVVTMTTVGYGDMKPITVGGKIVGSLCAIAGV----LTIALPVPVIVSNFNYFYHR- 569

  Fly   257 CCQLQRHQEHRRKSTPGTSTP------------SASSAANSREKDTDKRSKRRMANC---KGCQY 306
               ...::|..:.:....|.|            |.||:...:.:..:.....:.:.|   :.||.
Human   570 ---ETENEEQTQLTQNAVSCPYLPSNLLKKFRSSTSSSLGDKSEYLEMEEGVKESLCAKEEKCQG 631

  Fly   307 DAANSETSLNDC 318
            ...:|||..|:|
Human   632 KGDDSETDKNNC 643

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1688	NP_610516.1	Ion_trans_2	177..247	CDD:462301	14/54 (26%)
		Ion_trans_2	822..896	CDD:462301
KCNA4	NP_002224.1	K_channel_TID	1..>37	CDD:429748
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	24..148
		BTB_POZ	176..303	CDD:453885
		Ion_trans	306..570	CDD:459842	16/67 (24%)
		S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142	462..475
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	524..529		2/4 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	629..653		7/15 (47%)
		PDZ-binding. /evidence=ECO:0000250|UniProtKB:P15385	651..653