Protein Alignment CG1688 and KCNA1

DIOPT Version :10

• Sequence 1: NP_610516.1
• Gene: CG1688 / 36005
• FlyBaseID: FBgn0027589
• Length: 918
• Species: Drosophila melanogaster
• Sequence 2: NP_000208.2
• Gene: KCNA1 / 3736
• HGNCID: 6218
• Length: 495
• Species: Homo sapiens
• Alignment Length: 170
• Identity: 38/170 - (22%)
• Similarity: 68/170 - (40%)
• Gaps: 16/170 - (9%)

  Fly   166 GAGLFHEGSASALGHFGYDAGDSQSWSFSEALLYSVTVITTIGHGSLTPRTAAGKLATIFYALVG 230
            |..||    :||:.....:..:|...|..:|..::|..:||:|:|.:.|.|..||:.....|:.|
Human   336 GVILF----SSAVYFAEAEEAESHFSSIPDAFWWAVVSMTTVGYGDMYPVTIGGKIVGSLCAIAG 396

  Fly   231 VPLMLMCLSSLGALLADGLQCTYVRLC-----CQLQRHQEHRRKSTPGTSTPSASSAANSREKDT 290
            |    :.::....::.......|.|..     .||.........|....|..|:|:.:.|...:.
Human   397 V----LTIALPVPVIVSNFNYFYHRETEGEEQAQLLHVSSPNLASDSDLSRRSSSTMSKSEYMEI 457

  Fly   291 DKRSKRRMANCKGCQYDAANSETSLNDCLEYGQKGKLPPD 330
            ::.....:|:.:......||..|:..:|:   .|.||..|
Human   458 EEDMNNSIAHYRQVNIRTANCTTANQNCV---NKSKLLTD 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1688	NP_610516.1	Ion_trans_2	177..247	CDD:462301	16/69 (23%)
		Ion_trans_2	822..896	CDD:462301
KCNA1	NP_000208.2	Tetramerization domain. /evidence=ECO:0000250|UniProtKB:P10499	1..128
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..30
		BTB_POZ	37..163	CDD:453885
		Ion_trans	166..418	CDD:459842	21/89 (24%)
		S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142	310..323
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	372..377		2/4 (50%)
		PDZ-binding. /evidence=ECO:0000250	493..495		1/2 (50%)