Protein Alignment CG1688 and KCNK18

DIOPT Version :10

• Sequence 1: NP_610516.1
• Gene: CG1688 / 36005
• FlyBaseID: FBgn0027589
• Length: 918
• Species: Drosophila melanogaster
• Sequence 2: NP_862823.1
• Gene: KCNK18 / 338567
• HGNCID: 19439
• Length: 384
• Species: Homo sapiens
• Alignment Length: 195
• Identity: 56/195 - (28%)
• Similarity: 85/195 - (43%)
• Gaps: 41/195 - (21%)

  Fly    63 RRCCGHLLKLLFSTPGLVLL--VIGYSVLGGLLFPLLEAPQDISKSAAIAKSREDCLRELWIITE 125
            ||||...|..||  |||..|  ::.|:::|.::|..:|..|.:  .||.....|..|.||..|
Human    10 RRCCPEALGKLF--PGLCFLCFLVTYALVGAVVFSAIEDGQVL--VAADDGEFEKFLEELCRI-- 68

  Fly   126 KLNVLYERNWTMLVHEQLRRFEGSIVAATRQGSAGSSGGGGAGLFHEGSASALGHFGYDAGDSQS 190
             ||..     ..:|.::.:..:|.:.....|            .|:.               :..
Human    69 -LNCS-----ETVVEDRKQDLQGHLQKVKPQ------------WFNR---------------TTH 100

  Fly   191 WSFSEALLYSVTVITTIGHGSLTPRTAAGKLATIFYALVGVPLMLMCLSSLGALLADGLQCTYVR 255
            |||..:|.:..||.:|:|:|.:.|.|..||...:.|||.|:|||.:.|:..|.:||..|..:|.|
Human   101 WSFLSSLFFCCTVFSTVGYGYIYPVTRLGKYLCMLYALFGIPLMFLVLTDTGDILATILSTSYNR 165

  Fly   256  255
            Human   166  165

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1688	NP_610516.1	Ion_trans_2	177..247	CDD:462301	23/69 (33%)
		Ion_trans_2	822..896	CDD:462301
KCNK18	NP_862823.1	Ion_trans_2	94..155	CDD:462301	23/75 (31%)
		Selectivity filter 1. /evidence=ECO:0000305|PubMed:36426390	116..121		2/4 (50%)
		Interaction with calcineurin. /evidence=ECO:0000250|UniProtKB:Q6VV64	200..205
		Interaction with YWHAH. /evidence=ECO:0000250|UniProtKB:Q6VV64	249..254
		Ion_trans_2	285..364	CDD:462301
		Selectivity filter 2. /evidence=ECO:0000305|PubMed:36426390	323..328