DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1688 and Kcnk18

DIOPT Version :9

Sequence 1:	NP_610516.1	Gene:	CG1688 / 36005	FlyBaseID:	FBgn0027589	Length:	918	Species:	Drosophila melanogaster
Sequence 2:	NP_997144.1	Gene:	Kcnk18 / 332396	MGIID:	2685627	Length:	394	Species:	Mus musculus

Alignment Length:	360	Identity:	82/360 - (22%)
Similarity:	126/360 - (35%)	Gaps:	114/360 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 LTAKPRSSLRRCCGHLL------------KLLFSTPGLVLL--VIGYSVLGGLLFPLLEAPQD-- 102
            :.|:.....||||...|            |||   |||..|  ::.|:::|..||..:|...|
Mouse     1 MEAEEPPEARRCCPEALGKARGCCPEALGKLL---PGLCFLCCLVTYALVGAALFSAVEGRPDPE 62

  Fly   103 ISKSAAIAKSREDCLRELWIITEKLNVLYERNWTMLVHEQLRRFEGSIVAATRQGSAGSSGGGGA 167
            ..::..:.|..:|....|     |.|:.........:.|.|:..:...:.|
Mouse    63 AEENPELKKFLDDLCNIL-----KCNLTVVEGSRKNLCEHLQHLKPQWLKA-------------- 108

  Fly   168 GLFHEGSASALGHFGYDAGDSQSWSFSEALLYSVTVITTIGHGSLTPRTAAGKLATIFYALVGVP 232
                                .|.|||..||.:..||.:|:|:|.:.|.|..||...:.|||.|:|
Mouse   109 --------------------PQDWSFLSALFFCCTVFSTVGYGHMYPVTRLGKFLCMLYALFGIP 153

  Fly   233 LMLMCLSSLGALLADGLQCTYVR----LC-------------CQLQRHQEHRRKS---------- 270
            ||.:.|:.:|.:||..|...|.|    ||             |:.|...:...::
Mouse   154 LMFLVLTDIGDILATILSRAYSRFQALLCLPHDIFKWRSLPLCRKQPDSKPVEEAIPQIVIDAGV 218

  Fly   271 ------TPGTSTPSASSAANSREKDTDKRSKRRMANCKGCQYDAANSETSLNDCLEYGQKGKLPP 329
                  .|....||.|......|:...:..|.::      |......|.| |.|.|. ..|:|
Mouse   219 DELLNPQPSKDPPSPSCNVELFERLVAREKKNKL------QPPTRPVERS-NSCPEL-VLGRL-- 273

  Fly   330 DKKEGDACQLLRNLNPQQHFYQQQQQQPQQPDVML 364
                  :|.:|.||:       :..||.::.|:.|
Mouse   274 ------SCSILSNLD-------EVGQQVERLDIPL 295

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1688	NP_610516.1	Ion_trans_2	<191..247	CDD:285168	24/55 (44%)
CG1688	NP_610516.1	Ion_trans_2	822..896	CDD:285168
Kcnk18	NP_997144.1	Ion_trans_2	<111..166	CDD:285168	23/54 (43%)
		Interaction with calcineurin	210..215		0/4 (0%)
		Interaction with YWHAH. /evidence=ECO:0000269\|PubMed:18397886	261..266		2/5 (40%)
		Ion_trans_2	300..376	CDD:285168
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000030
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11003
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.870