DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1688 and Ork1

DIOPT Version :9

Sequence 1:	NP_610516.1	Gene:	CG1688 / 36005	FlyBaseID:	FBgn0027589	Length:	918	Species:	Drosophila melanogaster
Sequence 2:	NP_001285097.1	Gene:	Ork1 / 32020	FlyBaseID:	FBgn0017561	Length:	1019	Species:	Drosophila melanogaster

Alignment Length:	824	Identity:	136/824 - (16%)
Similarity:	232/824 - (28%)	Gaps:	355/824 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly   190 SWSFSEALLYSVTVITTIGHGSLTPRTAAGKLATIFYALVGVPLMLMCLSSLGALLADGLQCTYV 254
            :|:|..|..::.||.:|:|:|:::|.|.||::..|.|:::|:|:..:..:.||.......:..|
  Fly    89 TWTFYHAFFFAFTVCSTVGYGNISPTTFAGRMIMIAYSVIGIPVNGILFAGLGEYFGRTFEAIY- 152

  Fly   255 RLCCQLQRHQEHRRKS------------------------------------------------- 270
                  :|:::::..:
  Fly   153 ------RRYKKYKMSTDMHYVPPQLGLITTVVIALIPGIALFLLLPSWVFTYFENWPYSISLYYS 211

  Fly   271 --------------TPGTSTPS------------------------------------------A 279
                          |.|.:.|.                                          .
  Fly   212 YVTTTTIGFGDYVPTFGANQPKEFGGWFVVYQIFVIVWFIFSLGYLVMIMTFITRGLQSKKLAYL 276

  Fly   280 SSAANSREKDTDKR-----SK-----RRMAN---------C------------------KGCQYD 307
            ....:|..|.|..|     :|     |||.|         |                  |..:|.
  Fly   277 EQQLSSNLKATQNRIWSGVTKDVGYLRRMLNELYILKVKFCRKGNRKKPKNKAKTEQKKKSSRYI 341

  Fly   308 AANSETSLNDCLEYG----QKGKLPPDKKEGDAC------------------QLLRNLNPQQHFY 350
            |.....| |.|.:..    :...:|..|:....|                  ..|..|:.::.|
  Fly   342 AYTLPRS-NSCPDLSMYRVEPAPIPSRKRAFSVCADMVAAQREAGMVHANSDTELSKLDREKTF- 404

  Fly   351 QQQQQQPQQPDVMLMTTTSGSALLKYAPQQQQ----------------LQQQQQLSTA---TLPR 396
             :..:..:|...:|....:..|.:|..|.:|:                |..:...||.   |.||
  Fly   405 -ETAEAYRQTTDLLAKVVNALATVKPPPAEQEDAALYGGYHGFSDSQILASEWSFSTVNEFTSPR 468

  Fly   397 Q-------------------------HHQMQLQQQQQQLQQNFVAVPSSMLRMPLTVPPNCYAPA 436
            :                         |::.......||:|:.|
  Fly   469 RPRARACSDFNLEAPRWQSERPLRSSHNEWTWSGDNQQIQEAF---------------------- 511

  Fly   437 TATIYFPFGHAPSAPGSPAHNQAHPTQNPNGNALGNTTLGSQPLVKYHTIHLQP----------A 491
                                ||.:..|. ..|...|:|:          :||:|          :
  Fly   512 --------------------NQRYKGQQ-RANGAANSTM----------VHLEPDALEEQLKKQS 545

  Fly   492 SGKHRV----LASGLQDATAVNLVTASEASTSTLEAITLP---------PPPAYQTASVHAVRRA 543
            .|..||    :..||:..........|:.....|..:::|         .|..|.:.:|.|....
  Fly   546 PGAGRVKKFSMPDGLRRLFPFQKKRPSQDLERKLSVVSVPEGVISQQARSPLDYYSNTVTAASSQ 610

  Fly   544 KFV----AKPLPQEINALMDCGTGSPDLSG--RHDLLPPPHS--GSPATGTAASPLLTYTAAATS 600
            .::    ..|.|.|.|..:..|.|.....|  ..|...||.:  |......||:......:..|.
  Fly   611 SYLRNGRGPPPPFESNGSLASGGGGLTNMGFQMEDGATPPSALGGGAYQRKAAAGKRRRESIYTQ 675

  Fly   601 PQLSAGIKGGSGPAPTAGAPMLVSGAGRGAAALTDNGFMAAGVCGMGAAAAPLPVTSMGAATTTA 665
            .|..:..:|...| |||.| :......||:.|.:.:|..|     |.|.||..  .|:..||.:|
  Fly   676 NQAPSARRGSMYP-PTAHA-LAQMQMRRGSLATSGSGSAA-----MAAVAARR--GSLFPATASA 731

  Fly   666 SS--AASTLSALLSANSTGNVDIME--------------------DEDEQ--------------- 693
            ||  :|...|::.|..|..:::::|                    ||.:|
  Fly   732 SSLTSAPRRSSIFSVTSEKDMNVLEQTTIADLIRALEVVHTHAVLDEQQQAAAAGGAAGGGGISR 796

  Fly   694 ---ERERLSNCPHGTPSRVPLIASPLSVPQDSGENTTRNTAFNR 734
               ::.::.|.....|...|:    ||:.......|.:..|.||
  Fly   797 GSRKQRKMGNAGLEPPQLPPI----LSLFAGDQTRTLQAAAANR 836

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1688	NP_610516.1	Ion_trans_2	<191..247	CDD:285168	18/55 (33%)
CG1688	NP_610516.1	Ion_trans_2	822..896	CDD:285168
Ork1	NP_001285097.1	Ion_trans_2	<90..144	CDD:285168	18/53 (34%)
Ork1	NP_001285097.1	Ion_trans_2	185..269	CDD:285168	3/83 (4%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461333
Domainoid	1	1.000	56	1.000	Domainoid score	I2685
eggNOG	1	0.900	-	-		E1_KOG1418
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D774951at2759
OrthoFinder	1	1.000	-	-		FOG0000030
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11003
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
	8	7.850