Protein Alignment CG1688 and Kcnb1

DIOPT Version :10

• Sequence 1: NP_610516.1
• Gene: CG1688 / 36005
• FlyBaseID: FBgn0027589
• Length: 918
• Species: Drosophila melanogaster
• Sequence 2: NP_037318.2
• Gene: Kcnb1 / 25736
• RGDID: 2954
• Length: 857
• Species: Rattus norvegicus
• Alignment Length: 537
• Identity: 99/537 - (18%)
• Similarity: 181/537 - (33%)
• Gaps: 155/537 - (28%)

  Fly   184 DAGDSQSWSFSEALLYSVTVITTIGHGSLTPRTAAGKLATIFYALVGVPLMLMCLSSLGALLADG 248
            |..|::..|...:..::...:||:|:|.:.|:|..||:......:.||.::.:.:    .::.:.
  Rat   355 DEDDTKFKSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPI----PIIVNN 415

  Fly   249 LQCTYVRLCCQLQRHQE---HRRKSTPGTSTPSASSAANSR--------------EKD------T 290
            ....|     :.|:.||   .||::........:..:.|.:              ||:      .
  Rat   416 FSEFY-----KEQKRQEKAIKRREALERAKRNGSIVSMNMKDAFARSIEMMDIVVEKNGESIAKK 475

  Fly   291 DKRSKRRMANCKGCQYDAANSETSLNDCLEYGQKGKLPPDKKEGDACQLLRNLNPQQHFYQQQQQ 355
            ||.....::..|......|.||||.:...|..::|.  |:|....:.....|:...:..|.:..:
  Rat   476 DKVQDNHLSPNKWKWTKRALSETSSSKSFETKEQGS--PEKARSSSSPQHLNVQQLEDMYSKMAK 538

  Fly   356 QPQQPDVMLMTTTSGSALLKYAPQQQQLQQQQQLS----TATLPRQHHQMQLQQQQQQLQQNFVA 416
            ...||   ::.|.      :.|||.:..::.:..|    .|.||.:...: :..:......:|::
  Rat   539 TQSQP---ILNTK------EMAPQSKPPEELEMSSMPSPVAPLPARTEGV-IDMRSMSSIDSFIS 593

  Fly   417 VPSSMLRMPLTVPPNCYAPATATIYFPFGHAPSAP-GSPAHNQAHP------------------- 461
            ..:.            :..||.     |.|:|.|. .|.|.:...|
  Rat   594 CATD------------FPEATR-----FSHSPLASLSSKAGSSTAPEVGWRGALGASGGRLTETN 641

  Fly   462 -----------TQNPNGNALGNTTLGSQPL----VKYHTIHLQPASGKHR----------VLASG 501
                       .::|..:...|..|..:.|    |:.....|.|:.|.:.          ...:|
  Rat   642 PIPETSRSGFFVESPRSSMKTNNPLKLRALKVNFVEGDPTPLLPSLGLYHDPLRNRGGAAAAVAG 706

  Fly   502 LQDATAVNLVTASEAST--STLEAITLPPPPAYQTASVHAVRRAKFVAKPLPQEINALMDCGTGS 564
            |:.|:.::....|..|:  :|..|.|.|..|...||          :|......::..:|..|
  Rat   707 LECASLLDKPVLSPESSIYTTASARTPPRSPEKHTA----------IAFNFEAGVHHYIDTDT-- 759

  Fly   565 PDLSGRHDLLPPPHSGSPATGTAASPLLTYTAAATSPQLSAGIKG-----GSGPAPTAGAPML-- 622
             |..|:  ||....|..|.:          ...:|||:.|.|.:.     .|.|.||  :|..
  Rat   760 -DDEGQ--LLYSVDSSPPKS----------LHGSTSPKFSTGARTEKNHFESSPLPT--SPKFLR 809

  Fly   623 ---------VSGAGRGA 630
                     ::|.|.||
  Rat   810 PNCVYSSEGLTGKGPGA 826

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1688	NP_610516.1	Ion_trans_2	177..247	CDD:462301	13/62 (21%)
		Ion_trans_2	822..896	CDD:462301
Kcnb1	NP_037318.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21
		BTB_POZ_KCNB2	15..141	CDD:349719
		Self-association. /evidence=ECO:0000269|PubMed:18463252, ECO:0000269|PubMed:19690160	59..75
		Ion_trans	188..424	CDD:459842	14/77 (18%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	377..382		2/4 (50%)
		Self-association. /evidence=ECO:0000269|PubMed:18463252, ECO:0000269|PubMed:19690160	448..481		5/32 (16%)
		Kv2channel	467..678	CDD:397541	40/239 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	476..524		12/49 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	540..569		7/37 (19%)
		FFAT. /evidence=ECO:0000250|UniProtKB:Q14721	590..596		1/5 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	610..658		5/47 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	770..802		9/41 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	818..857		4/9 (44%)