DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1688 and twk-2

DIOPT Version :9

Sequence 1:	NP_610516.1	Gene:	CG1688 / 36005	FlyBaseID:	FBgn0027589	Length:	918	Species:	Drosophila melanogaster
Sequence 2:	NP_001350984.1	Gene:	twk-2 / 188452	WormBaseID:	WBGene00006657	Length:	1519	Species:	Caenorhabditis elegans

Alignment Length:	960	Identity:	193/960 - (20%)
Similarity:	320/960 - (33%)	Gaps:	350/960 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 LVLLVIGYSVLGGLLFPLLEAP-QDISKSA---AIAKSR----------------EDCLRELWII 123
            ||:.|..|:.:|..:|..||:| :|..|..   .||:.|                ||..:||.:.
Worm    40 LVVCVCIYATIGAWIFYTLESPNEDRLKETGRKTIAEMRSNLIYKINNNEKEVWKEDIEKELMLY 104

  Fly   124 TEKLNVLYERNWTMLVHEQLRRFEGSIVAATRQGSAGSSGGGGAGLFHEGSASALGHFGYDAGDS 188
            :|||...::..:......:...|||    .:....|..:||...........:..|    |.|..
Worm   105 SEKLYKAFKEQYVRYSDVRTIGFEG----RSSYEEADETGGDSERKRRHRHGNKRG----DRGSE 161

  Fly   189 QSWSFSEALLYSVTVITTIGHGSLTPRTAAGKLATIFYALVGVPLMLMCLSSLGALLADGLQCT- 252
            :.|:.|.||.::.|.:.|||:|::.|.|..|:||.:.:||.|.|:.::.:..||..|:   :||
Worm   162 KMWTTSSALFFAATTMATIGYGNIVPVTPLGRLACVLFALFGAPIAIITIGDLGKFLS---ECTI 223

  Fly   253 --YVRLCCQLQRHQEHRRKSTPGTSTPSASSAANSREKDTDKRSKRRMANCKGCQYDAANSETSL 315
              |           :|.||             .::|.....||.:              ..|.|:
Worm   224 WLY-----------KHMRK-------------GSARLDSAWKRFR--------------GLEDSI 250

  Fly   316 NDCLEYGQKGK----LPPDKKEGDACQ----------------------LLRNLNPQQHFYQQ-- 352
            :|.||...|.:    |..|..|.|..:                      :|.:.:....||..
Worm   251 SDDLESASKNQDSSILDMDMDEIDKSEVPVLMVFTIILLYIAFGGILFSILEDWSYMDAFYYSFI 315

  Fly   353 -------QQQQPQQPD----------VMLMTTT---------------------SGSALLKYAPQ 379
                   ....|:..|          |.|..||                     .|:.||:|..:
Worm   316 SLTTIGFGDIVPENHDYIAIMLIYLGVGLSVTTMCIDLAGIQYIQKIHYFGRKFQGTDLLQYLKK 380

  Fly   380 QQQLQQQQQLSTA--TLPRQHHQMQ-LQQQQQQLQQNF----------VAVPSSMLRMPLTV--- 428
            ::.|:::..:...  .|.:..|.:: .:::|:||||..          ....:||:|:..::
Worm   381 KRMLERRLAMGQGEEILRKYVHAVEKFEREQEQLQQKMEEEDPPSIESKGFDNSMMRIDDSLSAF 445

  Fly   429 ---------PPNCYAPATATIYFPFGHAPSA-PGSPAHNQAH--------PTQNPNGNALG-NTT 474
                     ..:.::|   ||:......||. ..|.|.:|:.        .:.:.:|.:|. :.:
Worm   446 QLRFYDTYDEEDLFSP---TIHSVRSFQPSVWSHSSARSQSFCRFQRNRGASWDESGPSLSEHCS 507

  Fly   475 LGSQPLV--------KYHTIHLQPASGKHRVL-----ASGLQ---DATAVNLVTASEASTSTLEA 523
            |.::|.|        .||:......|..||.|     ||.:.   |..|.:..:|..:::.....
Worm   508 LSTEPSVHIRQAYWDNYHSPTPSVISFLHRHLYSPSIASSISFDYDCLAKDAKSARRSNSCPPIE 572

  Fly   524 ITLPPPPAYQTASVHAVRRAKFVAKPLPQEINALMDCGTGSPDLSGRHDLLPPPHSGSPATGTAA 588
            |..|||    :.||.:.||      ||        ...||| .:..:|.:             |:
Worm   573 IPSPPP----SNSVSSPRR------PL--------SARTGS-TIRTKHAI-------------AS 605

  Fly   589 SPLLTYTAAATSPQLSAGIKGGSGPAPTAGAPMLVSGAGRGAAALTDNGFMAAGVCG---MGAAA 650
            .|:  ||||..|.:|.              .|.::|    ..||:.| .|..|..|.   .||..
Worm   606 EPI--YTAAPLSFRLP--------------EPFMLS----NLAAICD-AFDDADACNNLVFGAFR 649

  Fly   651 APLPVTSMGAATTTASSAASTLSALLSANS-------TGNVDIMEDEDEQERERLSNCPHGTPSR 708
                                  .:.|:||.       :|.|.:....|...       |...|..
Worm   650 ----------------------ESQLAANHYDSTDGFSGKVQLHPQPDILH-------PPPPPPY 685

  Fly   709 VP-LIASP--LSVPQDSGENTTRNTAFNRHTLQPLSRKTLLL---------TRR-----CHRHAS 756
            || |..||  |||..::..:|:......|...:.::|:...|         .||     |.:...
Worm   686 VPKLSLSPKRLSVIDENKISTSPEPVLKRKNKERIARQQNPLHSFDWLNVSPRRFRPELCIKEDL 750

  Fly   757 GTLYDSTANNTETS------------------------------------------DDEEYMQHG 779
            ..|:....|:|:.|                                          |.:.|:|..
Worm   751 PKLFKLVRNSTKISLESPTQTSETTETPLPDLSCDSNPESVVLISPRSPIGLACMQDWDSYIQML 815

  Fly   780 SEQFVLKKLRYHCDGKDCREAEDSEEEDEKADGRQVPISLVLLILASYIC 829
            .|  ..::.:|..:..| .|.|:.|:.||..|...:|    .::|:.|.|
Worm   816 EE--ASREFQYTPEDID-EEIEEEEDCDEDDDRECIP----HILLSDYEC 858

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1688	NP_610516.1	Ion_trans_2	<191..247	CDD:285168	21/55 (38%)
CG1688	NP_610516.1	Ion_trans_2	822..896	CDD:285168	3/8 (38%)
twk-2	NP_001350984.1	Ion_trans_2	<164..220	CDD:311712	21/58 (36%)
twk-2	NP_001350984.1	Ion_trans_2	285..360	CDD:311712	9/74 (12%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D542195at33208
OrthoFinder	1	1.000	-	-		FOG0000030
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11003
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920