DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1688 and twk-47

DIOPT Version :9

Sequence 1:	NP_610516.1	Gene:	CG1688 / 36005	FlyBaseID:	FBgn0027589	Length:	918	Species:	Drosophila melanogaster
Sequence 2:	NP_001309491.1	Gene:	twk-47 / 185227	WormBaseID:	WBGene00018002	Length:	500	Species:	Caenorhabditis elegans

Alignment Length:	452	Identity:	85/452 - (18%)
Similarity:	167/452 - (36%)	Gaps:	106/452 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 MGAKTTASLTAKP-RSSLRRCCGHLLKLLFSTPGLVLLVIGYSVLGGLLFPLLEAPQDISKSAAI 109
            |..:..:|.|..| ::.|::    :||:.....||.:.:..|.::|...|...|  .|..|.
Worm     1 MSEEENSSSTELPVQNKLKK----MLKMALPHVGLAVFLFLYLLIGAYAFYYQE--YDADKK--- 56

  Fly   110 AKSREDCLRELWIITEKLNVLYERNWTMLVHEQLRRFEGSIVAATRQGSAGSSGGGGAGLFHEGS 174
                        |...|||::.:|  ...:..:::.|.|:................|...:|||.
Worm    57 ------------IQMTKLNLIRQR--YKQIENEVKVFIGNDKKYEEYKPKLLKHLSGLSTYHEGR 107

  Fly   175 --ASALGHFGYDAGDSQSWSFSEALLYSVTVITTIGHGSLTPRTAAGKLATIFYALVGVPLMLMC 237
              .|.:.....||...: |:...::||:::::||.|:....|.|..|:...|.|.|||:|:|::.
Worm   108 EFKSTISGISDDALPPR-WTKRSSILYALSILTTTGYAYAVPVTPIGQCFAIIYGLVGIPMMVLA 171

  Fly   238 LSSLGALLAD---GLQCTYVRLCCQ--------LQRHQ---EHRR--------KSTPGT----ST 276
            ....|..|:.   .|...|:.|..:        |:||:   |.||        :.|..|    :|
Worm   172 AVDFGRFLSHIVLELYSKYLDLVHKLKIMKTVILERHRARDEKRRLHAFKRLVQDTGSTISECTT 236

  Fly   277 PSASSAANSREKDTDKRSKRRM---ANCK---------GCQYDAANSETSLNDC--LEYGQKGKL 327
            .........:..|:|:..::|:   .|..         |..|.||....:..:.  |.:.....|
Worm   237 QKDVQLEEEQTTDSDEMPEKRLPLVINASILLIFCMLGGVLYIAAGGRATFIESFFLTFNLVANL 301

  Fly   328 PPDKKEGD---------------------------ACQLLRNLNPQQHFYQQ----QQQQP-QQP 360
            ...:...:                           |...|:.|..:.|::.:    :::|| :|.
Worm   302 TMSEMPNELNHILTIIYIFVFVTCGVAVLSMSAELAALELKELFMKIHYFGRRINFKRRQPKEQM 366

  Fly   361 DVMLMTTTSGSALLKYAPQ-QQQLQQQQQLSTATLPRQHHQMQLQQQQQQLQQNFVAVPSSM 421
            ||.:      ..|||...: :::..::::::|..:....|:.....:..:.:.....:|.:|
Worm   367 DVQV------KELLKIIEEIRKRYPEKEKITTLDILEYMHENTANDKLNERRDTIAFMPQTM 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1688	NP_610516.1	Ion_trans_2	<191..247	CDD:285168	18/55 (33%)
CG1688	NP_610516.1	Ion_trans_2	822..896	CDD:285168
twk-47	NP_001309491.1	Ion_trans_2	<124..180	CDD:369572	17/56 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000030
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11003
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910