DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1688 and twk-22

DIOPT Version :9

Sequence 1:	NP_610516.1	Gene:	CG1688 / 36005	FlyBaseID:	FBgn0027589	Length:	918	Species:	Drosophila melanogaster
Sequence 2:	NP_001361830.1	Gene:	twk-22 / 181703	WormBaseID:	WBGene00006675	Length:	749	Species:	Caenorhabditis elegans

Alignment Length:	754	Identity:	155/754 - (20%)
Similarity:	247/754 - (32%)	Gaps:	276/754 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 RSSLRRCCGHLL----KLLFSTPG-----LVLLVIGYSVLGGLLFPLLEAPQ-----DISKSAAI 109
            :...|...||..    |.|:...|     |.|:::||:.|||.:|..||..|     ::.|...:
Worm   150 KQQYRETWGHWFVRVGKFLYKLLGIQYMLLALMILGYACLGGYIFLTLEYDQQQLDLEVEKQVRL 214

  Fly   110 AKSREDCLRELWIITEKLNVLYERNWTMLVHEQLRRFEGSIVAATRQGSAGSSGGGGAGLFHEGS 174
            ::|.        ::.|.| :.|.:.|......:.|..| .|..|                |.|.|
Worm   215 SEST--------LLAENL-LKYLKQWNCGQSNENRCLE-LITKA----------------FIERS 253

  Fly   175 ASALGHFGYDAGDSQSWSFSEALLYSVTVITTIGHGSLTPRTAAGKLATIFYALVGVPLMLMCLS 239
            .......   .|:...|.|..::.:|.|:.||||:|:|..:|..|::|||.|.|:|:||||..|.
Worm   254 IKVERDI---RGEGWRWDFWNSVFFSATIFTTIGYGNLACKTNLGRVATIIYGLIGIPLMLFVLK 315

  Fly   240 SLGALLADGLQCTYVRLCCQLQRHQEHRRKSTPGTSTPSASSAANSR------EKDTDKRSKRRM 298
            ..|                      ||           |...|...|      .|...:|||.:.
Worm   316 IFG----------------------EH-----------SIKWAQKVRYSIRRCVKRCFRRSKLKR 347

  Fly   299 ANCKGCQYDAANSETSLND---CLEYGQKGKLPPDKKEGD----------------ACQLLRN-- 342
                     |:..|:..:|   |.|.|    :..|:::..                .|.|:.:
Worm   348 ---------ASTIESVASDEMPCEESG----ISEDEEQITTFPVKWALFIVFFFMVVCSLIVSFW 399

  Fly   343 -----LNPQQHFYQQQQ---------QQPQQPDVMLMTTTSGSAL--LKYAPQQQQLQQQQQLST 391
                 |.....|:....         :.|:....:.:....|.||  :.||..|::::.|
Worm   400 EKWDFLTAFYFFFVSLSTIGFGDVIPEHPRTACALFVLYFVGLALFSMVYAILQERVENQ----- 459

  Fly   392 ATLPRQHHQMQLQQQQQQLQQNFVAVPSSMLRMPLTVPPNCYAPA--TATIYFPFGHAPSAPGSP 454
                   :...|:...|:.|:|....|...|.:|..:|.|.....  |.||    |...|.  :|
Worm   460 -------YMWALELIDQEYQENQKQDPDDHLEIPTILPENAAGMEGWTNTI----GKMVSQ--NP 511

  Fly   455 ----AHNQAHPTQNPNGNALGNTTLGSQPLVKYHTIHLQPASGKHRVLASGLQDATAVNLVTASE 515
                |.|.|:..:|          :..:|:          :..:..||:.|             |
Worm   512 VRWRAKNSAYSMEN----------MPDRPI----------SERRFSVLSPG-------------E 543

  Fly   516 ASTSTLEAITLPPPPAYQTASVHAVRRAKFVAKPLPQEINALMDCGTGSPD-LSGRHDLL----- 574
            |..:        |||...|..:|::...|   |.|.:..:.|...||..|. |...:::|
Worm   544 APQA--------PPPVLGTFMLHSLSVKK---KLLARSESILNRTGTKRPSTLFPSNEMLSTSAS 597

  Fly   575 -----PPPHS------------GSPATGTAASPLLTYTAAATSPQLSAGIKGGSGPAPTAGAPML 622
                 |.||:            |.|:....::|.||             |.||: .:|:.||..:
Worm   598 SSRGSPWPHAAEMNRPKEATRLGEPSALRVSAPNLT-------------ISGGN-RSPSGGALSV 648

  Fly   623 VSGA--------------------------GRGAAALTDNGFMAAGVCGMGAAAAPLPVTSMGAA 661
            ::.|                          ..|:|...|.......:.....|..|.|......:
Worm   649 ITEASDEDTRHFKKHRRPLAKTVSTDGTVSNHGSAESLDQVMDELQLESHDQAVTPKPYRDPTTS 713

  Fly   662 T------TTASSAASTLSALLSANSTGNVDIMEDEDEQE 694
            |      .|..|.|..:.  ||.|     :::|:|||.|
Worm   714 TRFRKRDETVVSRAEKMP--LSPN-----EVLEEEDEDE 745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1688	NP_610516.1	Ion_trans_2	<191..247	CDD:285168	24/55 (44%)
CG1688	NP_610516.1	Ion_trans_2	822..896	CDD:285168
twk-22	NP_001361830.1	Ion_trans_2	259..319	CDD:369572	25/84 (30%)
twk-22	NP_001361830.1	Ion_trans_2	381..457	CDD:369572	11/75 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D542195at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920