DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1688 and twk-11

DIOPT Version :9

Sequence 1:	NP_610516.1	Gene:	CG1688 / 36005	FlyBaseID:	FBgn0027589	Length:	918	Species:	Drosophila melanogaster
Sequence 2:	NP_504783.2	Gene:	twk-11 / 179088	WormBaseID:	WBGene00006666	Length:	1720	Species:	Caenorhabditis elegans

Alignment Length:	886	Identity:	164/886 - (18%)
Similarity:	281/886 - (31%)	Gaps:	305/886 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 DETDATEFGGLGGVGGAGC------GSEMGAKTTASLTAKPRSSLRRC---CGHL---LKLLFST 76
            |..|..|:....|...:.|      ..|......||:.....||.|:.   |..:   :|.|.||
Worm    11 DPPDDVEYDVEAGFNSSTCHLMHNFEEERPTSLVASIKESAISSKRKLKYYCSFICTPIKKLLST 75

  Fly    77 PGLVLLVIGYSVLGGLLFPLLEAPQDISKSAAIAKSRED------CLRELWIITEKLNVLYERNW 135
            ..|::::..||.:|..:|..||.|.|:       ::|||      ..||:.::..:. :.|:..
Worm    76 FKLLIIIGLYSFIGAHIFMYLEVPTDL-------EAREDGFHQRKIAREVMVLNLRA-IFYDNR- 131

  Fly   136 TMLVHEQLRRFEGSIVAATRQGSAGSSGGGGAGLFHEGSASALGHFGYDAGDSQS-----WSFSE 195
                .::..|::.:|:                            .|..|.|..:.     |:|..
Worm   132 ----EDREERWKHAIL----------------------------KFEEDIGLEEPVIETVWTFWM 164

  Fly   196 ALLYSVTVITTIGHGSLTPRTAAGKLATIFYALVGVPLMLMCLSSLGALLADGLQCTYVRLCCQL 260
            :.||:.|:.||||:|::..:|.||::||:.||.||:|:||:.|:||...|     ..:::|.
Worm   165 SFLYAGTIFTTIGYGNIACKTRAGQIATMVYAFVGIPIMLVMLTSLNNFL-----LKWIKLI--- 221

  Fly   261 QRHQEHRRKSTPGTSTPSASSAAN-----SREKDTDKRSK-----RRMANCKGCQYDAANSETSL 315
                      |.|.|..:......     .|:.:..||.:     :.|...|..::.|.:|....
Worm   222 ----------TNGVSDMTLYIGVRLGITVIRQDEVQKRLRYTKLAKTMKRWKLSKHGAPSSIAIS 276

  Fly   316 NDCLEYGQKGKLPPDKKEGDACQLLRNLNPQQHFYQQQQQQPQQPDVMLMTTTSGSALLKYAPQQ 380
            |.  |..:....|.|.:|                   :::..|.|.|:.....:.:.::
Worm   277 NS--EENRLNSTPEDDEE-------------------EEEIHQDPPVLSTLIATVAWII------ 314

  Fly   381 QQLQQQQQLSTATLPRQHHQMQLQQQQQQLQQNFVAVPSSMLRMPLTVPPNCYAPATATIYFPFG 445
                    ||.|..              .|.:::....|...         |:...|.     .|
Worm   315 --------LSAAVF--------------CLFEDWTFFTSFYF---------CFISLTT-----IG 343

  Fly   446 HAPSAPGSPAHNQAHPTQNPNGNALGNTTLGSQPLVKYHTIHLQPASGKHRVLASGLQDATA-VN 509
            .....|.:|.:..|         ..|...:|...|.               |....||:..| :.
Worm   344 LGDVTPANPEYMIA---------TFGVVIVGLSMLT---------------VCIDVLQEKLAQMY 384

  Fly   510 LVTASEASTSTLEAITLPPPPAYQTASVHAVRRAKFVAKPLPQEINALM------DCGTGSPDLS 568
            :....:..|..:||:....|.|..........||||:...:.:...|.:      ||.....|
Worm   385 MALLQKLLTEYMEAVKSGDPNAASAMMAGFQGRAKFLMPLISKNEGAKVMDKFKQDCSKKGID-- 447

  Fly   569 GRHDLLPP-------PHSGSPATGTA------------------------ASPLLTYTAAATSPQ 602
                  ||       |.:|.||...|                        .:||...|....||.
Worm   448 ------PPPVLTNINPETGMPAFANAPKEDFRDYIEVADEKFADEQQRLSQTPLSKSTDFLQSPT 506

  Fly   603 LSAGIKGGSGPAPTAGAPMLVSGAGRGAAALTDNGFMAAGVCGMGAAAAPLPVTSMGAATTTASS 667
                      |.||....:..:...:...:|.    :.||.. ||      .....|:.|.|.||
Worm   507 ----------PRPTVTVAVTQTARPQACVSLE----VQAGTT-MG------KFHDYGSQTQTESS 550

  Fly   668 AASTLSALLSANSTGNVDIMEDEDEQERERLSNCPHGTPSRVPLIASPLSVPQDSGENTTRNTAF 732
            ..       ...:..::| .:||..:|.|::. ...||...:.|:.|....|:.|
Worm   551 DE-------GIQTDYSID-FDDEKNKEPEKVM-ADIGTQYEIVLLTSIGIQPEVS---------- 596

  Fly   733 NRHTLQPLSRKTLLLTRRCHRHA---SGTLYDSTANNTETSDDEEYMQHGSEQFVLKKLRYHCDG 794
                       ::.:......|:   ||...:..:::::.|.|||.....|.::....|.:
Worm   597 -----------SIYIGAGLSDHSDEESGCESEDDSDDSDVSSDEESELKSSAKYKETPLPF---- 646

  Fly   795 KDCREAED------------------SEEEDEKADGRQVPI 817
                |.||                  :::|...:|.|..|:
Worm   647 ----EVEDPGMMSLGLQSPPIEITPFTDDESAASDARSSPV 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1688	NP_610516.1	Ion_trans_2	<191..247	CDD:285168	26/55 (47%)
CG1688	NP_610516.1	Ion_trans_2	822..896	CDD:285168
twk-11	NP_504783.2	Ion_trans_2	156..216	CDD:285168	26/64 (41%)
		Ion_trans	<305..384	CDD:278921	18/144 (13%)
		Ion_trans_2	307..382	CDD:285168	17/140 (12%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D542195at33208
OrthoFinder	1	1.000	-	-		FOG0000030
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920