DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1688 and Kcnk2

DIOPT Version :9

Sequence 1:	NP_610516.1	Gene:	CG1688 / 36005	FlyBaseID:	FBgn0027589	Length:	918	Species:	Drosophila melanogaster
Sequence 2:	NP_742039.1	Gene:	Kcnk2 / 170899	RGDID:	621448	Length:	426	Species:	Rattus norvegicus

Alignment Length:	185	Identity:	45/185 - (24%)
Similarity:	83/185 - (44%)	Gaps:	44/185 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 LVLLVIGYSVLGGLLFPLLEAPQDISKSAAIAKSREDCL-RELWIITEKLNVLYERNWTMLVHEQ 142
            :.|:|:.|.::|..:|..||.||:||:...|...:::.: :...:.:.:|:.|.::
  Rat    65 IFLVVVLYLIIGATVFKALEQPQEISQRTTIVIQKQNFIAQHACVNSTELDELIQQ--------- 120

  Fly   143 LRRFEGSIVAATRQGSAGSSGGGGAGLFHEGSASALGHFGYDAGDSQSWSFSEALLYSVTVITTI 207
                   ||.|...|                    :...|.::.....|....:..::.||||||
  Rat   121 -------IVTAINAG--------------------IIPLGNNSNQVSHWDLGSSFFFAGTVITTI 158

  Fly   208 GHGSLTPRTAAGKLATIFYALVGVPLMLMCLS----SLGALLADGL---QCTYVR 255
            |.|:::|||..||:..|.|||:|:||....|:    .||.:...|:   :.|:::
  Rat   159 GFGNISPRTEGGKIFCIIYALLGIPLFGFLLAGVGDQLGTIFGKGIAKVEDTFIK 213

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1688	NP_610516.1	Ion_trans_2	<191..247	CDD:285168	24/59 (41%)
CG1688	NP_610516.1	Ion_trans_2	822..896	CDD:285168
Kcnk2	NP_742039.1	Ion_trans_2	<139..196	CDD:285168	22/56 (39%)
		Ion_trans_2	234..312	CDD:285168
		Required for basal channel activity. /evidence=ECO:0000250\|UniProtKB:P97438	354..426
		Essential for chloroform and halothane sensitivity. /evidence=ECO:0000250\|UniProtKB:P97438	378..426
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000030
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11003
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.910