Protein Alignment CG1688 and Kcnk2

DIOPT Version :10

• Sequence 1: NP_610516.1
• Gene: CG1688 / 36005
• FlyBaseID: FBgn0027589
• Length: 918
• Species: Drosophila melanogaster
• Sequence 2: NP_001153322.1
• Gene: Kcnk2 / 16526
• MGIID: 109366
• Length: 426
• Species: Mus musculus
• Alignment Length: 186
• Identity: 49/186 - (26%)
• Similarity: 87/186 - (46%)
• Gaps: 46/186 - (24%)

  Fly    79 LVLLVIGYSVLGGLLFPLLEAPQDISKSAAIAKSREDCL-RELWIITEKLNVLYERNWTMLVHEQ 142
            :.|:|:.|.::|..:|..||.||:||:...|...::..: :...:.:.:|:.|.::
Mouse    65 IFLVVVLYLIIGATVFKALEQPQEISQRTTIVIQKQTFIAQHACVNSTELDELIQQ--------- 120

  Fly   143 LRRFEGSIVAATRQGSAGSSGGGGAGLFHEG-SASALGHFGYDAGDSQSWSFSEALLYSVTVITT 206
                   ||||.           .||:...| |::.:.|          |....:..::.|||||
Mouse   121 -------IVAAI-----------NAGIIPLGNSSNQVSH----------WDLGSSFFFAGTVITT 157

  Fly   207 IGHGSLTPRTAAGKLATIFYALVGVPLMLMCLS----SLGALLADGL---QCTYVR 255
            ||.|:::|||..||:..|.|||:|:||....|:    .||.:...|:   :.|:::
Mouse   158 IGFGNISPRTEGGKIFCIIYALLGIPLFGFLLAGVGDQLGTIFGKGIAKVEDTFIK 213

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1688	NP_610516.1	Ion_trans_2	177..247	CDD:462301	25/73 (34%)
		Ion_trans_2	822..896	CDD:462301
Kcnk2	NP_001153322.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..36
		Important for GNG4 binding and L-glutamate release in astrocytes. /evidence=ECO:0000250|UniProtKB:Q920B6	17..38
		Important for GNG4 binding and L-glutamate release in astrocytes. /evidence=ECO:0000250|UniProtKB:Q920B6	51..61
		Ion_trans_2	<138..196	CDD:462301	23/67 (34%)
		Selectivity filter 1. /evidence=ECO:0000250|UniProtKB:Q920B6	157..162		3/4 (75%)
		Ion_trans_2	234..312	CDD:462301
		Selectivity filter 2. /evidence=ECO:0000250|UniProtKB:Q920B6	266..271
		Interaction with AKAP5. /evidence=ECO:0000305|PubMed:17110924	298..311
		Interaction with AKAP5. /evidence=ECO:0000305|PubMed:17110924	313..326
		Essential for chloroform and halothane sensitivity. /evidence=ECO:0000269|PubMed:10321245	337..385