Protein Alignment CG1688 and Kcnk1

DIOPT Version :10

• Sequence 1: NP_610516.1
• Gene: CG1688 / 36005
• FlyBaseID: FBgn0027589
• Length: 918
• Species: Drosophila melanogaster
• Sequence 2: NP_032456.2
• Gene: Kcnk1 / 16525
• MGIID: 109322
• Length: 336
• Species: Mus musculus
• Alignment Length: 209
• Identity: 52/209 - (24%)
• Similarity: 83/209 - (39%)
• Gaps: 59/209 - (28%)

  Fly    34 LGGVGGAGCGSEMGAKTTASLTAKPRSSLRRCCGHLLKLLFSTPGLVLLVIGYSVLGGLLFPLLE 98
            |..:.|:.|         ..|..:.||:.  |.|.          |||..:.|.|.|.::|..:|
Mouse     2 LQSLAGSSC---------VRLVERHRSAW--CFGF----------LVLGYLLYLVFGAVVFSSVE 45

  Fly    99 APQDISKSAAIAKSREDCLR-ELWIITEKLNVLYERNWTMLVHEQLRRFEGSIVAATRQGSAGSS 162
            .|.            ||.|| ||    .||...:......|...||.:|.|.::.|:..|.:..|
Mouse    46 LPY------------EDLLRQEL----RKLKRRFLEEHECLSEPQLEQFLGRVLEASNYGVSVLS 94

  Fly   163 GGGGAGLFHEGSASALGHFGYDAGDSQSWSFSEALLYSVTVITTIGHGSLTPRTAAGKLATIFYA 227
            ...|                     :.:|.|:.||.::.||::|.|:|...|.:..||...|.|:
Mouse    95 NASG---------------------NWNWDFTSALFFASTVLSTTGYGHTVPLSDGGKAFCIIYS 138

  Fly   228 LVGVPLMLMCLSSL 241
            ::|:|..|:.|:::
Mouse   139 VIGIPFTLLFLTAV 152

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1688	NP_610516.1	Ion_trans_2	177..247	CDD:462301	18/65 (28%)
		Ion_trans_2	822..896	CDD:462301
Kcnk1	NP_032456.2	Ion_trans_2	<98..157	CDD:462301	19/76 (25%)
		Selectivity filter 1. /evidence=ECO:0000250|UniProtKB:O00180	117..122		2/4 (50%)
		Ion_trans_2	191..267	CDD:462301
		Selectivity filter 2. /evidence=ECO:0000250|UniProtKB:O00180	225..230
		Important for intracellular retention in recycling endosomes. /evidence=ECO:0000250|UniProtKB:O00180	293..299
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	310..336