DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG1688 and Kcnd2

DIOPT Version :10

Sequence 1:NP_610516.1 Gene:CG1688 / 36005 FlyBaseID:FBgn0027589 Length:918 Species:Drosophila melanogaster
Sequence 2:NP_062671.1 Gene:Kcnd2 / 16508 MGIID:102663 Length:630 Species:Mus musculus


Alignment Length:530 Identity:109/530 - (20%)
Similarity:170/530 - (32%) Gaps:175/530 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    42 CGSEMGAKTTASLTAKPRSSLRRCCGHLLKLLF---STPGLVLLVIGYSVLGGLLFPLLEAPQDI 103
            |||..|     .:...|       ||....:.|   .|..:::..:.|      |..|..||   
Mouse   209 CGSSPG-----HIKELP-------CGERYAVAFFCLDTACVMIFTVEY------LLRLAAAP--- 252

  Fly   104 SKSAAIAKSREDCLRELWIITEKLNVL-YERNWTMLVHEQ-------LRRFEGSIVAATRQGSAG 160
                    ||...:|.:..|.:.:.:| |.....|..:|.       ||.|.   |....:.|..
Mouse   253 --------SRYRFVRSVMSIIDVVAILPYYIGLVMTDNEDVSGAFVTLRVFR---VFRIFKFSRH 306

  Fly   161 SSGGGGAGLFHEGSASALGH----------------FGYDAGDSQS--WSFSEALLYSVTVITTI 207
            |.|....|...:..||.||.                |..:.|.|.|  .|...|..|::..:||:
Mouse   307 SQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPAAFWYTIVTMTTL 371

  Fly   208 GHGSLTPRTAAGKLATIFYALVGVPLMLMCLSSLGALLADGLQCTYVRLCCQLQRHQEHRRKSTP 272
            |:|.:.|:|.|||:.....:|.||.::        ||....:...:.|:..|.||..:.|     
Mouse   372 GYGDMVPKTIAGKIFGSICSLSGVLVI--------ALPVPVIVSNFSRIYHQNQRADKRR----- 423

  Fly   273 GTSTPSASSAANSREKDTDKRSKRRMANCKGCQYDAANSETSLNDCLEYGQKGKLPPDKKEGDAC 337
                               .:.|.|:|..:..:..:||:         |.|      .|:.|   
Mouse   424 -------------------AQKKARLARIRAAKSGSANA---------YMQ------SKRNG--- 451

  Fly   338 QLLRNLNPQQHFYQQQQQQPQQPDVMLMTTTSGSALLKYAPQQQQLQQQQQLSTATLPRQHHQMQ 402
             ||.|         |.|....:|   ...:.|||                     :...|||.: 
Mouse   452 -LLSN---------QLQSSEDEP---AFISKSGS---------------------SFETQHHHL- 481

  Fly   403 LQQQQQQLQQNFV---AVPSSMLRMPLTVPPNCYAPATATIYFPFGHAPSAPG-----SPAHNQA 459
            |...::.....||   ....|.:.:             ||:..|..|:||...     |...::.
Mouse   482 LHCLEKTTNHEFVDEQVFEESCMEV-------------ATVNRPSSHSPSLSSQQGVTSTCCSRR 533

  Fly   460 HPT--QNPNGNALGNTTLGSQPL--VKYHTIHLQPASGKHRVLASGLQDATAVNLVTASEASTST 520
            |..  :.||.|..|:.....|.|  ::...:...|.|.....|.:.:::...:|    .|....|
Mouse   534 HKKTFRIPNANVSGSHRGSVQELSTIQIRCVERTPLSNSRSSLNAKMEECVKLN----CEQPYVT 594

  Fly   521 LEAITLPPPP 530
            ...|::|.||
Mouse   595 TAIISIPTPP 604

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG1688NP_610516.1 Ion_trans_2 177..247 CDD:462301 23/87 (26%)
Ion_trans_2 822..896 CDD:462301
Kcnd2NP_062671.1 Interaction with KCNIP1, KCNIP2, and other family members. /evidence=ECO:0000250|UniProtKB:Q63881 2..20
BTB_POZ 6..144 CDD:453885
Interaction with KCNIP1. /evidence=ECO:0000250|UniProtKB:Q63881 71..90
Ion_trans 184..415 CDD:459842 56/245 (23%)
S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142 308..321 2/12 (17%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 370..375 2/4 (50%)
DUF3399 470..546 CDD:463381 21/110 (19%)
Important for normal channel activation and inactivation, for interaction with KCNIP2, and probably other family members as well. /evidence=ECO:0000250|UniProtKB:Q63881 474..630 31/149 (21%)
Required for dendritic targeting. /evidence=ECO:0000250|UniProtKB:Q63881 474..489 4/15 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 600..623 3/5 (60%)
PDZ-binding. /evidence=ECO:0000250|UniProtKB:Q63881 627..630
Blue background indicates that the domain is not in the aligned region.

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