DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trpl and Trpc6

DIOPT Version :9

Sequence 1:	NP_476895.1	Gene:	trpl / 36003	FlyBaseID:	FBgn0005614	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	NP_446011.1	Gene:	Trpc6 / 89823	RGDID:	619788	Length:	930	Species:	Rattus norvegicus

Alignment Length:	872	Identity:	300/872 - (34%)
Similarity:	467/872 - (53%)	Gaps:	137/872 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 LLLEEKKFLLAVERGDMPNVRRILQKALRHQHININCMDPLGRRALTLAIDNENLEMVELLVVMG 102
            |.:||::||.|.|.|::|.||::|::.|   .:|:||:|.:|:.||.||:.||:||:.|||:...
  Rat    94 LSIEEERFLDAAEYGNIPVVRKMLEECL---SLNVNCVDYMGQNALQLAVANEHLEITELLLKKE 155

  Fly   103 VETK--DALLHAINAEFVEAVELLLEHEELIYKEGEPYS------------WQKVDINTAMFAPD 153
            ..::  ||||.||:..:|..||.:|.|.  .:.||:..:            :...|.:...|:.|
  Rat   156 NLSRVGDALLLAISKGYVRIVEAILNHP--AFAEGKRLATSPSQSELQQDDFYAYDEDGTRFSHD 218

  Fly   154 ITPLMLAAHKNNFEILRILLDRGAAVPVPHDIRCGCEECVRLTAEDSLRHSLSRVNIYRALCSPS 218
            :||::||||...:||:..||.:||.:..|||..|.|.||.:....||..||.||:|.|:.|.||:
  Rat   219 VTPIILAAHCQEYEIVHTLLRKGARIERPHDYFCKCTECSQKQKHDSFSHSRSRINAYKGLASPA 283

  Fly   219 LICLTSNDPIITAFQLSWELRNLALTEQECKSEYMDLRRQCQKFAVDLLDQTRTSNELAIILNYD 283
            .:.|:|.||::||.:||.||..||..|:|.|::|..|..||:.|.|.|||..|.:.|:..|||.|
  Rat   284 YLSLSSEDPVMTALELSNELAVLANIEKEFKNDYRKLSMQCKDFVVGLLDLCRNTEEVEAILNGD 348

  Fly   284 PQMSSYEPGD--RMSLTRLVQAISYKQKKFVAHSNIQQLLSSIWYDGLPGFRRKSIVDKVICIAQ 346
            .:  :.:|||  |.:|:||..||.|:.||||||.|.||.|.||||:.|.|.|::::..|.:.:..
  Rat   349 AE--TRQPGDLARPNLSRLKLAIKYEVKKFVAHPNCQQQLLSIWYENLSGLRQQTMAVKFLVVLA 411

  Fly   347 VAVLFPLYCLIYMCAPNCRTGQLMRKPFMKFLIHASSYLFFLFILILVSQRADDDFVRIFGTTRM 411
            ||:..|...|||.|||..:.|:::|.|||||:.||:|:..||.:|::  ..||    |..||..:
  Rat   412 VAIGLPFLALIYWCAPCSKMGKILRGPFMKFVAHAASFTIFLGLLVM--NAAD----RFEGTKLL 470

  Fly   412 KKELAEQELRQ--RGQTP--SKLELIVVMYVIGFVWEEVQEIFAVGMKSYLRNMWNFIDFLRNSL 472
            ..|.:....||  |.:|.  |.:|::::.:|||.:|.|.:||:..|.|.||..:||.:||...::
  Rat   471 PNETSTDNARQLFRMKTSCFSWMEMLIISWVIGMIWAECKEIWTQGPKEYLFELWNMLDFGMLAI 535

  Fly   473 YVSVMCLRAFAY---------------IQQATEIARDPQMAY--IPREKWHDFDPQLIAEGLFAA 520
            :.:....|..|:               ::..|::.....:.|  :.|.||...|||:|:|||:|.
  Rat   536 FAASFIARFMAFWHASKAQSIIDANDTLKDLTKVTLGDNVKYYNLARIKWDPTDPQIISEGLYAI 600

  Fly   521 ANVFSALKLVHLFSINPHLGPLQISLGRMVIDIVKFFFIYTLVLFAFACGLNQLLWYFAALEKSK 585
            |.|.|..::.::...|...|||||||||.|.||.||..|:.:|..||..|:..|..|:...::::
  Rat   601 AVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYIGAKQNE 665

  Fly   586 CYVLPGGEADWGSHGDSCMKWRRFGNLFESSQSLFWASFGMVGLDDFELSGIKSYTRFWGLLMFG 650
            .                      |..:.||.::||||.||:..:....::....:....|.:::|
  Rat   666 A----------------------FTTVEESFKTLFWAIFGLSEVKSVVINYNHKFIENIGYVLYG 708

  Fly   651 SYSVINVIVLLNLLIAMMSNSYAMIDEHSDTEWKFARTKLWMSYFEDSATLPPPFNVLPSVKWVI 715
            .|:|..||||||:||||:::|:..|::.:|.||||||.|||.||||:..|||.|||::||.|.::
  Rat   709 VYNVTMVIVLLNMLIAMINSSFQEIEDDADVEWKFARAKLWFSYFEEGRTLPVPFNLVPSPKSLL 773

  Fly   716 RIFRKSSKTI-------------DRQRSKKRKEQE-----------QFS---------------- 740
            .:..|..|.:             |.:.:|:.:|::           :||
  Rat   774 YLLLKFKKWMSELIQGHKKGFQEDAEMNKRNEEKKFGILGSHEDLSKFSLDRNQLAHNKQSSTRS 838

  Fly   741 --------------EYDNIMRSLVWRYVAAMHRKFENNPVSEDDINEVKSEINTMRYEML----- 786
                          :|..||:.|:.|||.......|::.|:|.::.|:|.:|:::|||:|
  Rat   839 SEDFHLNSFSNPPRQYQKIMKRLIKRYVLQAQIDKESDEVNEGELKEIKQDISSLRYELLEEKSQ 903

  Fly   787 ------EIFENSGMDVSSANKKERQPR 807
                  |:....|..:|..:|:|...|
  Rat   904 NTEDLAELIRKLGERLSLESKQEESRR 930

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trpl	NP_476895.1	trp	48..784	CDD:273311	286/826 (35%)
		ANK	48..195	CDD:238125	59/160 (37%)
		ANK repeat	78..114	CDD:293786	17/37 (46%)
		ANK repeat	134..177	CDD:293786	15/54 (28%)
		TRP_2	187..246	CDD:285535	27/58 (47%)
		DUF2031	<706..>805	CDD:299055	33/163 (20%)
Trpc6	NP_446011.1	trp	81..896	CDD:273311	291/836 (35%)
		ANK	104..238	CDD:238125	48/138 (35%)
		ANK repeat	131..158	CDD:293786	12/26 (46%)
		ANK repeat	160..184	CDD:293786	11/25 (44%)
		ANK repeat	211..246	CDD:293786	14/34 (41%)
		TRP_2	252..311	CDD:285535	27/58 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3609
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	5	4.770