DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trpl and Trpc1

DIOPT Version :9

Sequence 1:	NP_476895.1	Gene:	trpl / 36003	FlyBaseID:	FBgn0005614	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	XP_008764790.1	Gene:	Trpc1 / 89821	RGDID:	619783	Length:	809	Species:	Rattus norvegicus

Alignment Length:	816	Identity:	299/816 - (36%)
Similarity:	467/816 - (57%)	Gaps:	85/816 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 TGVSSG---VSHASSAPKSVGGCCVPLGLPQPLLLEEKKFLLAVERGDMPNVRRILQKALRHQHI 70
            :||||.   .|.:||:|..|........:.:...|.||.||||.::||...|::||::. ....:
  Rat    28 SGVSSSSLPSSPSSSSPNEVMALKDVREVKEENTLNEKLFLLACDKGDYYMVKKILEEN-SSGDL 91

  Fly    71 NINCMDPLGRRALTLAIDNENLEMVELLVVMGVETKDALLHAINAEFVEAVELLLEH------EE 129
            ||||:|.|||.|:|:.|:||:|::::||:..|.::.||||.||::|.|.||::||.|      ..
  Rat    92 NINCVDVLGRNAVTITIENESLDILQLLLDYGCQSADALLVAIDSEVVGAVDILLNHRPKRSSRP 156

  Fly   130 LIYKEGEPYSWQKVDINTAMFAPDITPLMLAAHKNNFEILRILLDRGAAVPVPHDIRCGCEECVR 194
            .|.|..|..  |..:.:|.|   |:.|::||||:||:|||.:||.:..|:|.||.:.|.|..|..
  Rat   157 TIVKLMERI--QNPEYSTTM---DVAPVILAAHRNNYEILTMLLKQDVALPKPHAVGCECTLCSA 216

  Fly   195 LTAEDSLRHSLSRVNIYRALCSPSLICLTSNDPIITAFQLSWELRNLALTEQECKSEYMDLRRQC 259
            ...:||||||..|::|||.|.||:||.||..|||:.||:||.:|:.|:|.|.|.:::|.:|.|||
  Rat   217 KNKKDSLRHSRFRLDIYRCLASPALIMLTEEDPILRAFELSADLKELSLVEVEFRNDYEELARQC 281

  Fly   260 QKFAVDLLDQTRTSNELAIILNYDPQMSSYEPGD-------RMSLTRLVQAISYKQKKFVAHSNI 317
            :.||.|||.|.|.|.||.:|||:   .||.||.|       ||:|:||..||.|.||:||:.||.
  Rat   282 KMFAKDLLAQARNSRELEVILNH---TSSDEPLDKRGLLEERMNLSRLKLAIKYNQKEFVSQSNC 343

  Fly   318 QQLLSSIWYDGLPGFRRKSIVDKVICIAQVAVLFPLYCLIYMCAPNCRTGQLMRKPFMKFLIHAS 382
            ||.|:::|:..:.|:|||....|::.:..|.:.:|:..|.|:.||..:.|:::..|||||:||.:
  Rat   344 QQFLNTVWFGQMSGYRRKPTCKKIMTVLTVGIFWPVLSLCYLIAPKSQFGRIIHTPFMKFIIHGA 408

  Fly   383 SYLFFLFILILVSQRADDDFVRIFGTTRMKKELAEQELRQRGQTPSKLELIVVMYVIGFVWEEVQ 447
            ||..||.:|.|.|...::|          ||       ...|....:::.::::::||.:|.:::
  Rat   409 SYFTFLLLLNLYSLVYNED----------KK-------NTMGPALERIDYLLILWIIGMIWSDIK 456

  Fly   448 EIFAVGMKSYLRNMWNFIDFLRNSLYVSVMCLRAFAYIQQATEIARDPQMAYIPREKWHDFDPQL 512
            .::..|::.:|....|.:.|:.||||::...|:.         :|.:....:..|:.|..|.|.|
  Rat   457 RLWYEGLEDFLEESRNQLSFVMNSLYLATFALKV---------VAHNKFHDFADRKDWDAFHPTL 512

  Fly   513 IAEGLFAAANVFSALKLVHLFSINPHLGPLQISLGRMVIDIVKFFFIYTLVLFAFACGLNQLLWY 577
            :||||||.|||.|.|:|..:::.:..|||||||:|:|:.|..||..::.||||:|..||.||  |
  Rat   513 VAEGLFAFANVLSYLRLFFMYTTSSILGPLQISMGQMLQDFGKFLGMFLLVLFSFTIGLTQL--Y 575

  Fly   578 ---FAALEKSKCYVLPGGEADWGSHGDSCMKWRR--FGNLFESSQSLFWASFGMVGLDDF--ELS 635
               :.:.|:..|.            |..|.:...  |.:...:..:|||..|.:..:..|  ..|
  Rat   576 DKGYTSKEQKDCV------------GIFCEQQSNDTFHSFIGTCFALFWYIFSLAHVAIFVTRFS 628

  Fly   636 GIKSYTRFWGLLMFGSYSVINVIVLLNLLIAMMSNSYAMIDEHSDTEWKFARTKLWMSYFEDSAT 700
            ..:....|.|.::.|:|:|:.||||..||:||:..|:.:|..|.|.||||||.|||:|||:|..|
  Rat   629 YGEELQSFVGAVIVGTYNVVVVIVLTKLLVAMLHKSFQLIANHEDKEWKFARAKLWLSYFDDKCT 693

  Fly   701 LPPPFNVLPSVKWVIRIFRKSSK---------TIDRQRSKK---RKEQEQFSEYDNIMRSLVWRY 753
            ||||||::||.|.:..:....||         .:.||.|.|   ..:|::...|..:|..||.||
  Rat   694 LPPPFNIIPSPKTICYMISSLSKWVCSHTSKGKVRRQNSLKEWRNLKQKRDENYQKVMCCLVHRY 758

  Fly   754 VAAMHRKFEN-NPVSEDDINEVKSEINTMRYEMLEI 788
            :.:|.:|.:: :..:.:::||::.:::..|.|:.::
  Rat   759 LTSMRQKMQSTDQATVENLNELRQDLSKFRNEIRDL 794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trpl	NP_476895.1	trp	48..784	CDD:273311	283/768 (37%)
		ANK	48..195	CDD:238125	62/152 (41%)
		ANK repeat	78..114	CDD:293786	17/35 (49%)
		ANK repeat	134..177	CDD:293786	17/42 (40%)
		TRP_2	187..246	CDD:285535	30/58 (52%)
		DUF2031	<706..>805	CDD:299055	23/96 (24%)
Trpc1	XP_008764790.1	trp	64..790	CDD:273311	288/774 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341886
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D355630at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102173
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.750