DRSC/TRiP Functional Genomics Resources

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Protein Alignment trpl and Trpc4

DIOPT Version :10

Sequence 1:NP_476895.1 Gene:trpl / 36003 FlyBaseID:FBgn0005614 Length:1124 Species:Drosophila melanogaster
Sequence 2:NP_536321.1 Gene:Trpc4 / 84494 RGDID:621276 Length:977 Species:Rattus norvegicus


Alignment Length:1034 Identity:399/1034 - (38%)
Similarity:582/1034 - (56%) Gaps:159/1034 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    42 EKKFLLAVERGDMPNVRRILQKALRHQHININCMDPLGRRALTLAIDNENLEMVELLVVMGVETK 106
            ||.:|.|||:||..:|::.|::|..:..|||||:|||||.||.:||:|||||::|||:...|...
  Rat    33 EKAYLNAVEKGDYASVKKSLEEAEIYFKININCIDPLGRTALLIAIENENLELIELLLSFNVYVG 97

  Fly   107 DALLHAINAEFVEAVELLLEHEELIYKEGEPYSWQKV-----DINTAMFAPDITPLMLAAHKNNF 166
            |||||||..|.|.||||||.|:       :|...::|     |...:.|.|||||::||||.||:
  Rat    98 DALLHAIRKEVVGAVELLLNHK-------KPSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNY 155

  Fly   167 EILRILLDRGAAVPVPHDIRCGCEECVRLTAEDSLRHSLSRVNIYRALCSPSLICLTSNDPIITA 231
            ||:::|:.:|.:||.||::||.|.|||..:..||||||.||:|||:||.|||||.|:|.||.:||
  Rat   156 EIIKLLVQKGVSVPRPHEVRCNCVECVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTA 220

  Fly   232 FQLSWELRNLALTEQECKSEYMDLRRQCQKFAVDLLDQTRTSNELAIILNYDPQMSSYEPGDRMS 296
            |||||||:.|:..|.|.||||.:|.|||::||.|||||||:|.||.|||||....|..|......
  Rat   221 FQLSWELQELSKVENEFKSEYEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLIEEQSGND 285

  Fly   297 LTRLVQAISYKQKKFVAHSNIQQLLSSIWYDGLPGFRRKSIVDKVICIAQVAVLFPLYCLIYMCA 361
            |.||..||.|:||:|||..|.||||:|.|||..||:||:....|::....:.:|||::.:.|:.|
  Rat   286 LARLKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIA 350

  Fly   362 PNCRTGQLMRKPFMKFLIHASSYLFFLFILILVSQRADDDFVRIFGTTRMKKELAEQELRQRGQT 426
            |....|..:||||:||:.|.:|||.|||:|:|.||..|                 ..:|.::|..
  Rat   351 PKSPLGLFIRKPFIKFICHTASYLTFLFLLLLASQHID-----------------RSDLNRQGPP 398

  Fly   427 PSKLELIVVMYVIGFVWEEVQEIFAVGMKSYLRNMWNFIDFLRNSLYVSVMCLRAFAYIQQATEI 491
            |:.:|.:::.:|:||:|.|:::::..|::.|:.:.||.:||:.||||::.:.|:..|:::.:   
  Rat   399 PTIVEWMILPWVLGFIWGEIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYS--- 460

  Fly   492 ARDPQMAYIPREKWHDFDPQLIAEGLFAAANVFSALKLVHLFSINPHLGPLQISLGRMVIDIVKF 556
                  |..|||.|..:.|.|:||.|||.||:||:|:|:.||:.|.||||||||||||::||:||
  Rat   461 ------ALNPRESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKF 519

  Fly   557 FFIYTLVLFAFACGLNQLLWYFAALEKSKCYVLPGGEADWGSHGDSCMKWRR-FGNLFESSQSLF 620
            .|||.|||.|||.|||||.:|:...:...|            .|..|.|... |..|||:.||||
  Rat   520 LFIYCLVLLAFANGLNQLYFYYEETKGLSC------------KGIRCEKQNNAFSTLFETLQSLF 572

  Fly   621 WASFGMVGLDDFELSGIKSYTRFWGLLMFGSYSVINVIVLLNLLIAMMSNSYAMIDEHSDTEWKF 685
            |:.||::.|....:.....:|.|.|..|||:|:||:::||||:|||||:|||.:|.:|:|.||||
  Rat   573 WSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKF 637

  Fly   686 ARTKLWMSYFEDSATLPPPFNVLPS-------VKWV--------IRIFRKSSKTIDRQRSKKRKE 735
            |||||||||||:..|||.||||:||       |||:        :|...:|..||.|:.:...:.
  Rat   638 ARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLVKWIWTHLCKKKMRRKPESFGTIGRRAADNLRR 702

  Fly   736 QEQFSEYDNIMRSLVWRYVAAMHRKFENNP-VSEDDINEVKSEINTMRYEMLEIFE--------- 790
            ..|:.|   :||:||.||||||.|:.:... ::|:::.|:|.:|::.|:|:|.:..         
  Rat   703 HHQYQE---VMRNLVKRYVAAMIREAKTEEGLTEENVKELKQDISSFRFEVLGLLRGSKLSTIQS 764

  Fly   791 -NSGMDVSSANKKER-----------------------QPRPRRIKVWERRLMKG----FQVAPV 827
             |:....|||:..|:                       .||...|......|..|    .|..|.
  Rat   765 ANAASSASSADSDEKSHSEGNGKDKRKNLSLFDLTTLIHPRSAVIASERHNLSNGSALVVQEPPR 829

  Fly   828 QNGCELDAFGNVNGQGEMQEIKVESIPSKPAKETAKERFQRVARTVLLQSTTHKWNVVLRAAKDS 892
            :...:::...::...|         :..:.:|:.|.|           |:....::|.....:..
  Rat   830 EKQRKVNFVADIKNFG---------LFHRRSKQNAAE-----------QNANQIFSVSEEITRQQ 874

  Fly   893 QIGRCTKNERKSLQNLGRAIEEAKRLIMLNPGCPSGRESPIRIEFEDEKTSTL-LELLNQISAEI 956
            ..|...:|.:  |::.|.|....:.:..||..|       :.::..:..|.|| |::..::.:..
  Rat   875 AAGALERNIQ--LESQGLASRGDRSIPGLNEQC-------VLVDHRERNTDTLGLQVGKRVCSSF 930

  Fly   957 SDSEKPKIRPIWRPPLKTVPARAMAANNTRSLTAPELKISRK--SSPAPTPTPTPGVSH 1013
            . |||..:.       .|||            ..|:.|.:::  ||.....:||..|:|
  Rat   931 K-SEKVVVE-------DTVP------------IIPKEKHAQEEDSSIDYDLSPTDTVAH 969

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trplNP_476895.1 TRPV 48..784 CDD:454755 350/757 (46%)
ANK repeat 78..114 CDD:293786 22/35 (63%)
ANK repeat 134..177 CDD:293786 18/47 (38%)
TRP_CaM_bind1 798..883 CDD:467881 15/111 (14%)
PHA03247 <961..1069 CDD:223021 12/55 (22%)
Trpc4NP_536321.1 trp 17..749 CDD:273311 353/763 (46%)
ANK 1. /evidence=ECO:0000250|UniProtKB:Q9UBN4 29..60 11/26 (42%)
ANK 2. /evidence=ECO:0000250|UniProtKB:Q9UBN4 71..93 13/21 (62%)
ANK 3. /evidence=ECO:0000250|UniProtKB:Q9UBN4 96..118 15/21 (71%)
ANK repeat 122..167 CDD:293786 18/44 (41%)
ANK 4. /evidence=ECO:0000250|UniProtKB:Q9UBN4 141..165 14/23 (61%)
Interaction with ITPR1, ITPR2 and ITPR3. /evidence=ECO:0000250|UniProtKB:Q9UBN4 615..977 107/407 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 767..790 4/22 (18%)
PDZ-binding domain. /evidence=ECO:0000250|UniProtKB:Q9UBN4 975..977
Blue background indicates that the domain is not in the aligned region.

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