DRSC/TRiP Functional Genomics Resources

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Protein Alignment trpl and TRPC5

DIOPT Version :10

Sequence 1:NP_476895.1 Gene:trpl / 36003 FlyBaseID:FBgn0005614 Length:1124 Species:Drosophila melanogaster
Sequence 2:NP_036603.1 Gene:TRPC5 / 7224 HGNCID:12337 Length:973 Species:Homo sapiens


Alignment Length:808 Identity:354/808 - (43%)
Similarity:499/808 - (61%) Gaps:78/808 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly    30 VPLGLPQ---PLLLEEKKFLLAVERGDMPNVRRILQKALRHQHININCMDPLGRRALTLAIDNEN 91
            :||.:.:   .|..|||.||.|||:||...|::.||:|..:.::||||||||||.||.:||:|||
Human    18 IPLQIVRAETELSAEEKAFLNAVEKGDYATVKQALQEAEIYYNVNINCMDPLGRSALLIAIENEN 82

  Fly    92 LEMVELLVVMGVETKDALLHAINAEFVEAVELLLEHEELIYKEGEPYSWQKV-----DINTAMFA 151
            ||::|||:...|...||||:||..|.|.||||||.:.       .|...::|     |...:.|.
Human    83 LEIMELLLNHSVYVGDALLYAIRKEVVGAVELLLSYR-------RPSGEKQVPTLMMDTQFSEFT 140

  Fly   152 PDITPLMLAAHKNNFEILRILLDRGAAVPVPHDIRCGCEECVRLTAEDSLRHSLSRVNIYRALCS 216
            |||||:|||||.||:||:::|:.:...:|.||.|||.|.|||..:..||||||.||:|||:||.|
Human   141 PDITPIMLAAHTNNYEIIKLLVQKRVTIPRPHQIRCNCVECVSSSEVDSLRHSRSRLNIYKALAS 205

  Fly   217 PSLICLTSNDPIITAFQLSWELRNLALTEQECKSEYMDLRRQCQKFAVDLLDQTRTSNELAIILN 281
            ||||.|:|.|||:|||:|.|||:.|:..|.|.|:||.:|.:||:.||.|||||.|:|.||.||||
Human   206 PSLIALSSEDPILTAFRLGWELKELSKVENEFKAEYEELSQQCKLFAKDLLDQARSSRELEIILN 270

  Fly   282 Y-DPQMSSYEPGDRMSLTRLVQAISYKQKKFVAHSNIQQLLSSIWYDGLPGFRRKSIVDKVICIA 345
            : |......:|.....|.:|..||.|.||:|||..|.||||:::||||.||:|||..|.|::...
Human   271 HRDDHSEELDPQKYHDLAKLKVAIKYHQKEFVAQPNCQQLLATLWYDGFPGWRRKHWVVKLLTCM 335

  Fly   346 QVAVLFPLYCLIYMCAPNCRTGQLMRKPFMKFLIHASSYLFFLFILILVSQRADDDFVRIFGTTR 410
            .:..|||:..:.|:.:|....|..::|||:||:.|.:|||.|||:|:|.||              
Human   336 TIGFLFPMLSIAYLISPRSNLGLFIKKPFIKFICHTASYLTFLFMLLLASQ-------------- 386

  Fly   411 MKKELAEQELRQRGQTPSKLELIVVMYVIGFVWEEVQEIFAVGMKSYLRNMWNFIDFLRNSLYVS 475
               .:...:|..:|..|:.:|.:::.:|:||:|.|::|::..|...|:.:.||.:||..||||::
Human   387 ---HIVRTDLHVQGPPPTVVEWMILPWVLGFIWGEIKEMWDGGFTEYIHDWWNLMDFAMNSLYLA 448

  Fly   476 VMCLRAFAYIQQATEIARDPQMAYIPREKWHDFDPQLIAEGLFAAANVFSALKLVHLFSINPHLG 540
            .:.|:..||::         .....|||:|..:.|.||||.|||.:|:.|:|:|:.||:.|.|||
Human   449 TISLKIVAYVK---------YNGSRPREEWEMWHPTLIAEALFAISNILSSLRLISLFTANSHLG 504

  Fly   541 PLQISLGRMVIDIVKFFFIYTLVLFAFACGLNQLLWYF---AALEKSKCYVLPGGEADWGSHGDS 602
            |||||||||::||:||.|||.|||.|||.|||||.:|:   |..|.:.|            .|..
Human   505 PLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYETRAIDEPNNC------------KGIR 557

  Fly   603 CMKWRR-FGNLFESSQSLFWASFGMVGLDDFELSGIKSYTRFWGLLMFGSYSVINVIVLLNLLIA 666
            |.|... |..|||:.|||||:.||::.|....:.....:|.|.|..|||:|:||:::||||:|||
Human   558 CEKQNNAFSTLFETLQSLFWSVFGLLNLYVTNVKARHEFTEFVGATMFGTYNVISLVVLLNMLIA 622

  Fly   667 MMSNSYAMIDEHSDTEWKFARTKLWMSYFEDSATLPPPFNVLPSVKWVIRIFRKSSKTI----DR 727
            ||:|||.:|.:|:|.||||||||||||||::..|||||||::||.|..:.:....:.|.    |.
Human   623 MMNNSYQLIADHADIEWKFARTKLWMSYFDEGGTLPPPFNIIPSPKSFLYLGNWFNNTFCPKRDP 687

  Fly   728 QRSKKRKEQEQFSE-----------YDNIMRSLVWRYVAAMHRKFENNP-VSEDDINEVKSEINT 780
            ...::|:....|:|           |..::|:||.||||||.|..:.:. ::|::..|:|.:|::
Human   688 DGRRRRRNLRSFTERNADSLIQNQHYQEVIRNLVKRYVAAMIRNSKTHEGLTEENFKELKQDISS 752

  Fly   781 MRYEMLEIFEN----SGMDVSSANKKER 804
            .|||:|::..|    .....||....:|
Human   753 FRYEVLDLLGNRKHPRSFSTSSTELSQR 780

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trplNP_476895.1 TRPV 48..784 CDD:454755 339/761 (45%)
ANK repeat 78..114 CDD:293786 21/35 (60%)
ANK repeat 134..177 CDD:293786 19/47 (40%)
TRP_CaM_bind1 798..883 CDD:467881 2/7 (29%)
PHA03247 <961..1069 CDD:223021
TRPC5NP_036603.1 trp 17..756 CDD:273311 347/782 (44%)
ANK 1. /evidence=ECO:0000269|PubMed:37137991, ECO:0007744|PDB:7X6C, ECO:0007744|PDB:7X6I, ECO:0007744|PDB:8GVW, ECO:0007744|PDB:8GVX 30..60 14/29 (48%)
ANK repeat 35..67 CDD:293786 15/31 (48%)
ANK repeat 69..98 CDD:293786 16/28 (57%)
ANK 2. /evidence=ECO:0000269|PubMed:37137991, ECO:0007744|PDB:7X6C, ECO:0007744|PDB:7X6I, ECO:0007744|PDB:8GVW, ECO:0007744|PDB:8GVX 69..97 16/27 (59%)
ANK 3. /evidence=ECO:0000269|PubMed:37137991, ECO:0007744|PDB:7X6C, ECO:0007744|PDB:7X6I, ECO:0007744|PDB:8GVW, ECO:0007744|PDB:8GVX 98..124 15/32 (47%)
ANK 4. /evidence=ECO:0000269|PubMed:37137991, ECO:0007744|PDB:7X6C, ECO:0007744|PDB:7X6I, ECO:0007744|PDB:8GVW, ECO:0007744|PDB:8GVX 141..170 15/28 (54%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 766..794 3/15 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 810..837
Essential for binding to NHERF1 PDZ domain. /evidence=ECO:0000250|UniProtKB:Q9QX29 971..973
Blue background indicates that the domain is not in the aligned region.

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