DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trpl and TRPC3

DIOPT Version :9

Sequence 1:	NP_476895.1	Gene:	trpl / 36003	FlyBaseID:	FBgn0005614	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	XP_011530519.1	Gene:	TRPC3 / 7222	HGNCID:	12335	Length:	937	Species:	Homo sapiens

Alignment Length:	854	Identity:	293/854 - (34%)
Similarity:	461/854 - (53%)	Gaps:	134/854 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 LLLEEKKFLLAVERGDMPNVRRILQKALRHQHININCMDPLGRRALTLAIDNENLEMVELLVVMG 102
            |..||::||.|.|.|::|.||::|:::   :.:|:||:|.:|:.||.||:.||:||:.|||:...
Human   109 LTAEEERFLDAAEYGNIPVVRKMLEES---KTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKE 170

  Fly   103 --VETKDALLHAINAEFVEAVELLLEH---------------EELIYKEGEPYSWQKVDINTAMF 150
              ....||||.||:..:|..||.:|.|               :||  ::.:.|::   |.:...|
Human   171 NLARIGDALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQEL--QDDDFYAY---DEDGTRF 230

  Fly   151 APDITPLMLAAHKNNFEILRILLDRGAAVPVPHDIRCGCEECVRLTAEDSLRHSLSRVNIYRALC 215
            :|||||::||||...:|::.:||.:||.:..|||..|.|.:|:.....||..||.||:|.|:.|.
Human   231 SPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCGDCMEKQRHDSFSHSRSRINAYKGLA 295

  Fly   216 SPSLICLTSNDPIITAFQLSWELRNLALTEQECKSEYMDLRRQCQKFAVDLLDQTRTSNELAIIL 280
            ||:.:.|:|.||::||.:||.||..||..|:|.|::|..|..||:.|.|.:||..|.|.|:..||
Human   296 SPAYLSLSSEDPVLTALELSNELAKLANIEKEFKNDYRKLSMQCKDFVVGVLDLCRDSEEVEAIL 360

  Fly   281 NYDPQMSSYEPGD----RMSLTRLVQAISYKQKKFVAHSNIQQLLSSIWYDGLPGFRRKSIVDKV 341
            |.|  :.|.||.:    :.||:|:..||.|:.||||||.|.||.|.:|||:.|.|.|.::|..|.
Human   361 NGD--LESAEPLEVHRHKASLSRVKLAIKYEVKKFVAHPNCQQQLLTIWYENLSGLREQTIAIKC 423

  Fly   342 ICIAQVAVLFPLYCLIYMCAPNCRTGQLMRKPFMKFLIHASSYLFFLFILILVSQRADDDFVRIF 406
            :.:..||:..|...:.|..||..|.|:::|.|||||:.||:|::.||.:|:.   .|.|   |..
Human   424 LVVLVVALGLPFLAIGYWIAPCSRLGKILRSPFMKFVAHAASFIIFLGLLVF---NASD---RFE 482

  Fly   407 GTTRMKK----ELAEQELRQRGQTPSKLELIVVMYVIGFVWEEVQEIFAVGMKSYLRNMWNFIDF 467
            |.|.:..    :..:|..|.:....:..|::::::|:|.:|.|.:|::..|.:.|:..:||.:||
Human   483 GITTLPNITVTDYPKQIFRVKTTQFTWTEMLIMVWVLGMMWSECKELWLEGPREYILQLWNVLDF 547

  Fly   468 LRNSLYVSVMCLRAFAYIQ---------------QATEIARDPQMAYI--PREKWHDFDPQLIAE 515
            ...|::::....|..|::|               ..:|:...|::.|.  .|:||...|||:|:|
Human   548 GMLSIFIAAFTARFLAFLQATKAQQYVDSYVQESDLSEVTLPPEIQYFTYARDKWLPSDPQIISE 612

  Fly   516 GLFAAANVFSALKLVHLFSINPHLGPLQISLGRMVIDIVKFFFIYTLVLFAFACGLNQLLWYFAA 580
            ||:|.|.|.|..::.::...|...|||||||||.|.||.||..::.:|.|||..|:..|..|:..
Human   613 GLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLG 677

  Fly   581 LEKSKCYVLPGGEADWGSHGDSCMKWRRFGNLFESSQSLFWASFGMVGLDDFELSGIKSYTRFWG 645
            .:.:..                      |..:.||.::|||:.||:..:....|.....:....|
Human   678 AKVNAA----------------------FTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIG 720

  Fly   646 LLMFGSYSVINVIVLLNLLIAMMSNSYAMIDEHSDTEWKFARTKLWMSYFEDSATLPPPFNVLPS 710
            .:::|.|:|..|:||||:||||:::||..|::.||.||||||:|||:|||:|..||||||:::||
Human   721 YVLYGIYNVTMVVVLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPS 785

  Fly   711 VK----WVIRIF-------RKSSKTID-----------------------------RQRSKKRKE 735
            .|    :::||.       |:..|.|:                             .|.:.:..|
Human   786 PKSFVYFIMRIVNFPKCRRRRLQKDIEMGMGNSKSRFTKCFPVHLNLMQRCELNLFTQSNSRVFE 850

  Fly   736 QEQF-------SEYDNIMRSLVWRYVAAMHRKFENNPVSEDDINEVKSEINTMRYEMLEIFENSG 793
            ...|       :.|..||:.|:.|||.......||:.|:|.::.|:|.:|:::|||:||
Human   851 SHSFNSILNQPTRYQQIMKRLIKRYVLKAQVDKENDEVNEGELKEIKQDISSLRYELLE------ 909

  Fly   794 MDVSSANKK 802
             |.|.|.::
Human   910 -DKSQATEE 917

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trpl	NP_476895.1	trp	48..784	CDD:273311	281/824 (34%)
		ANK	48..195	CDD:238125	59/163 (36%)
		ANK repeat	78..114	CDD:293786	17/37 (46%)
		ANK repeat	134..177	CDD:293786	15/42 (36%)
		TRP_2	187..246	CDD:285535	26/58 (45%)
		DUF2031	<706..>805	CDD:299055	33/144 (23%)
TRPC3	XP_011530519.1	trp	96..906	CDD:273311	286/834 (34%)
		ANK	119..253	CDD:238125	49/141 (35%)
		ANK repeat	146..177	CDD:293786	12/30 (40%)
		ANK repeat	226..261	CDD:293786	15/34 (44%)
		TRP_2	267..326	CDD:285535	26/58 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3609
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	4	3.770