DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trpl and Trpc3

DIOPT Version :9

Sequence 1:	NP_476895.1	Gene:	trpl / 36003	FlyBaseID:	FBgn0005614	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	XP_006232344.2	Gene:	Trpc3 / 60395	RGDID:	61973	Length:	909	Species:	Rattus norvegicus

Alignment Length:	854	Identity:	297/854 - (34%)
Similarity:	465/854 - (54%)	Gaps:	119/854 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 KSVGGCCVPLGLPQP-LLLEEKKFLLAVERGDMPNVRRILQKALRHQHININCMDPLGRRALTLA 86
            ::|.|.....|...| |..||::||.|.|.|::|.||::|:::   :.:|:||:|.:|:.||.||
  Rat    81 QAVRGPAFMFGARGPSLTAEEERFLDAAEYGNIPVVRKMLEES---RTLNVNCVDYMGQNALQLA 142

  Fly    87 IDNENLEMVELLVVMG--VETKDALLHAINAEFVEAVELLLEH---------------EELIYKE 134
            :.||:||:.|||:...  ....||||.||:..:|..||.:|.|               :||  ::
  Rat   143 VGNEHLEVTELLLKKENLARIGDALLLAISKGYVRIVEAILGHPGFAASRRLTLSPCEQEL--RD 205

  Fly   135 GEPYSWQKVDINTAMFAPDITPLMLAAHKNNFEILRILLDRGAAVPVPHDIRCGCEECVRLTAED 199
            .:.|::   |.:...|:|||||::||||.:.:|::.:||.:||.:..|||..|.|.:|......|
  Rat   206 DDFYAY---DEDGTRFSPDITPIILAAHCHKYEVVHLLLLKGARIERPHDYFCRCADCAEKQRLD 267

  Fly   200 SLRHSLSRVNIYRALCSPSLICLTSNDPIITAFQLSWELRNLALTEQECKSEYMDLRRQCQKFAV 264
            :..||.||:|.|:.|.||:.:.|:|.||::||.:||.||..||..|:|.|::|..|..||:.|.|
  Rat   268 AFSHSRSRINAYKGLASPAYLSLSSEDPVLTALELSNELAKLANIEKEFKNDYRKLSMQCKDFVV 332

  Fly   265 DLLDQTRTSNELAIILNYDPQMSSYEP----GDRMSLTRLVQAISYKQKKFVAHSNIQQLLSSIW 325
            .:||..|.|.|:..|||.|  :.|.||    |.:.||:|:..||.|:.||||||.|.||.|.:||
  Rat   333 GVLDLCRDSEEVEAILNGD--LESVEPLERHGHKASLSRVKLAIKYEVKKFVAHPNCQQQLLTIW 395

  Fly   326 YDGLPGFRRKSIVDKVICIAQVAVLFPLYCLIYMCAPNCRTGQLMRKPFMKFLIHASSYLFFLFI 390
            |:.|.|.|.::|..|.:.:..||:..|...:.|..||..|.|:::|.|||||:.||:|::.||.:
  Rat   396 YENLSGLREQTIAIKCLVVLVVALGLPFLAIGYWIAPCSRLGKILRSPFMKFVAHAASFIIFLGL 460

  Fly   391 LILVSQRADDDFVRIFGTTRMKK----ELAEQELRQRGQTPSKLELIVVMYVIGFVWEEVQEIFA 451
            |:.   .|.|   |..|.|.:..    :..:|..|.:....:..|::::::|:|.:|.|.:|::.
  Rat   461 LVF---NASD---RFEGITTLPNITVIDYPKQIFRVKTTQFTWTEMLIMVWVLGMMWSECKELWL 519

  Fly   452 VGMKSYLRNMWNFIDFLRNSLYVSVMCLRAFAYIQ---------------QATEIARDPQMAYI- 500
            .|.:.|:..:||.:||...|::::....|..|::|               ..:|:...|::.|.
  Rat   520 EGPREYIVQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSHVQESDLSEVTLPPEVQYFT 584

  Fly   501 -PREKWHDFDPQLIAEGLFAAANVFSALKLVHLFSINPHLGPLQISLGRMVIDIVKFFFIYTLVL 564
             .|:||...|||:|:|||:|.|.|.|..::.::...|...|||||||||.|.||.||..::.:|.
  Rat   585 YARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVF 649

  Fly   565 FAFACGLNQLLWYFAALEKSKCYVLPGGEADWGSHGDSCMKWRRFGNLFESSQSLFWASFGMVGL 629
            .||..|:..|..|:...:     |.|.                 |..:.||.::|||:.||:..:
  Rat   650 LAFMIGMFILYSYYLGAK-----VNPA-----------------FTTVEESFKTLFWSIFGLSEV 692

  Fly   630 DDFELSGIKSYTRFWGLLMFGSYSVINVIVLLNLLIAMMSNSYAMIDEHSDTEWKFARTKLWMSY 694
            ....|.....:....|.:::|.|:|..|:||||:||||:::||..|::.||.||||||:|||:||
  Rat   693 TSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSY 757

  Fly   695 FEDSATLPPPFNVLPSVK----WVIRIFR--------------------KSSKTIDRQRSKKRKE 735
            |:|..||||||:::||.|    :::||..                    ||...:..|.:.:..|
  Rat   758 FDDGKTLPPPFSLVPSPKSFVYFIMRITNFSKCRRRRLQKDLELGMGNSKSRLNLFTQSNSRVFE 822

  Fly   736 QEQF-------SEYDNIMRSLVWRYVAAMHRKFENNPVSEDDINEVKSEINTMRYEMLEIFENSG 793
            ...|       :.|..||:.|:.|||.......||:.|:|.::.|:|.:|:::|||:||
  Rat   823 SHSFNSILNQPTRYQQIMKRLIKRYVLKAQVDKENDEVNEGELKEIKQDISSLRYELLE------ 881

  Fly   794 MDVSSANKK 802
             |.|.|.::
  Rat   882 -DKSQATEE 889

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trpl	NP_476895.1	trp	48..784	CDD:273311	281/808 (35%)
		ANK	48..195	CDD:238125	59/163 (36%)
		ANK repeat	78..114	CDD:293786	17/37 (46%)
		ANK repeat	134..177	CDD:293786	15/42 (36%)
		TRP_2	187..246	CDD:285535	25/58 (43%)
		DUF2031	<706..>805	CDD:299055	32/128 (25%)
Trpc3	XP_006232344.2	trp	84..878	CDD:273311	289/831 (35%)
		ANK repeat	134..165	CDD:293786	12/30 (40%)
		ANK repeat	214..249	CDD:293786	15/34 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3609
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	5	4.770