DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trpl and trpc7a

DIOPT Version :9

Sequence 1:	NP_476895.1	Gene:	trpl / 36003	FlyBaseID:	FBgn0005614	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	NP_001276808.1	Gene:	trpc7a / 567566	ZFINID:	ZDB-GENE-091113-40	Length:	842	Species:	Danio rerio

Alignment Length:	844	Identity:	291/844 - (34%)
Similarity:	447/844 - (52%)	Gaps:	118/844 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 EEKKFLLAVERGDMPNVRRILQKALRHQHININCMDPLGRRALTLAIDNENLEMVELLVVMG--V 103
            ||::||.|.|.|::|:||::|:::   :.:|:||:|.:|:.||.||:.||:||:.|||:...  .
Zfish    34 EEERFLDAAEYGNIPSVRKMLEES---KTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKEGLA 95

  Fly   104 ETKDALLHAINAEFVEAVELLLEH---------------EELIYKEGEPYSWQKVDINTAMFAPD 153
            ...||||.||:..:|..||.:|.|               :||  ::.:.|::   |.:...|:.|
Zfish    96 RVGDALLLAISKGYVRIVEAILAHPAFEGGLRLTLSPLEQEL--RDDDFYAY---DEDGTRFSQD 155

  Fly   154 ITPLMLAAHKNNFEILRILLDRGAAVPVPHDIRCGCEECVRLTAEDSLRHSLSRVNIYRALCSPS 218
            |||::||||...:||:.|||.:||.:..|||..|.|.||.....:||..||.||:|.|:.|.|.:
Zfish   156 ITPMILAAHCKEYEIVHILLLKGARIEKPHDYFCKCGECAEKQKQDSFSHSRSRMNAYKGLASAA 220

  Fly   219 LICLTSNDPIITAFQLSWELRNLALTEQECKSEYMDLRRQCQKFAVDLLDQTRTSNELAIILNYD 283
            .:.|:|.||::||.:||.||..||..|.|.|::|..|..||:.|.|.:||..|.:.|:..|||.|
Zfish   221 YLSLSSEDPVLTALELSNELAQLANIETEFKNDYRKLSMQCKDFVVGVLDLCRNTEEVEAILNGD 285

  Fly   284 PQMSSYEPGDRMSLTRLVQAISYKQKKFVAHSNIQQLLSSIWYDGLPGFRRKSIVDKVICIAQVA 348
            ...:......|..|:|:..||.|:.||||||.|.||.|.::||:.|.|.|::||..|...:..|.
Zfish   286 VDQNHPSEHHRPCLSRVKLAIKYEVKKFVAHPNCQQRLLTLWYENLSGLRQQSIGVKCWTVLGVM 350

  Fly   349 VLFPLYCLIYMCAPNCRTGQLMRKPFMKFLIHASSYLFFLFILILVSQRADDDFVRIFGTTRMKK 413
            |..|...:.|...|..:.||::|.|||||:.||.|:..||.:|:|   .|.|.|.   |...:..
Zfish   351 VGLPFLAIAYWIMPFSKVGQVLRSPFMKFVAHAVSFTLFLCLLVL---NASDRFA---GVKTLPN 409

  Fly   414 ELAEQELRQ--RGQTP--SKLELIVVMYVIGFVWEEVQEIFAVGMKSYLRNMWNFIDFLRNSLYV 474
            |......||  |.:|.  |..|::::.:|:|.:|.|.:|::|.|.:.|:.::||.:||...|::|
Zfish   410 ETITDHPRQIFRIKTTQFSWTEMLIMKWVLGMIWTECKEVWADGPREYIMHLWNVLDFGMLSVFV 474

  Fly   475 SVMCLRAFAYIQQA---------------TEIARDPQMAYI--PREKWHDFDPQLIAEGLFAAAN 522
            :....|..|::|.:               ...:....:||.  .|.:|...|||||:|||::.|.
Zfish   475 ASFTARLMAFLQASQAQLYVDLYVTNADLINASLPADVAYFTYARNRWLPSDPQLISEGLYSIAV 539

  Fly   523 VFSALKLVHLFSINPHLGPLQISLGRMVIDIVKFFFIYTLVLFAFACGLNQLLWYFAALEKSKCY 587
            |.|..::.::...|...|||||||||.|.||.||..|:.:|..||..|:..|..|:...:.:..
Zfish   540 VLSFSRIAYVLPANESFGPLQISLGRTVKDIFKFMVIFIMVFLAFMIGMFNLYSYYLGAKYNPA- 603

  Fly   588 VLPGGEADWGSHGDSCMKWRRFGNLFESSQSLFWASFGMVGLDDFELSGIKSYTRFWGLLMFGSY 652
                                 |..:.||.::|||:.||:..:....|.....:....|.:::|.|
Zfish   604 ---------------------FTTVEESFKTLFWSIFGLSEVISVVLKYDHKFIENIGYILYGVY 647

  Fly   653 SVINVIVLLNLLIAMMSNSYAMIDEHSDTEWKFARTKLWMSYFEDSATLPPPFNVLPSVK----- 712
            :|..|:||||:||||:::||..|:|.:|.||||||.|||:|||::.:|||.|||::||.|
Zfish   648 NVTMVVVLLNMLIAMINHSYQEIEEDADVEWKFARAKLWLSYFDEGSTLPAPFNLIPSPKSFYYM 712

  Fly   713 -----------WVIRIFRKSSKT---IDRQRSKKRK-----EQEQF---------SEYDNIMRSL 749
                       ...|:...||:.   :...|||..:     .||.|         :.|..:|:.|
Zfish   713 AQRTKACLVSLCKARVRSNSSQQDMGMANSRSKLYRFRPYHSQEGFTVRNPIKHPTRYQKLMKRL 777

  Fly   750 VWRYVAAMHRKFENNPVSEDDINEVKSEINTMRYEML-----------EIFENSGMDVSSANKK 802
            :.|||.......|:|.::|.::.|:|.:|:::|||:|           |:.:..|..:|..||:
Zfish   778 IKRYVLKAQIDSESNEINEGELKEIKQDISSLRYELLEEKSQATEELAELIQELGDKLSKGNKR 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trpl	NP_476895.1	trp	48..784	CDD:273311	279/806 (35%)
		ANK	48..195	CDD:238125	61/163 (37%)
		ANK repeat	78..114	CDD:293786	17/37 (46%)
		ANK repeat	134..177	CDD:293786	16/42 (38%)
		TRP_2	187..246	CDD:285535	26/58 (45%)
		DUF2031	<706..>805	CDD:299055	34/141 (24%)
trpc7a	NP_001276808.1	trp	18..812	CDD:273311	283/813 (35%)
		ANK	41..175	CDD:238125	50/141 (35%)
		ANK repeat	68..99	CDD:293786	12/30 (40%)
		ANK repeat	100..146	CDD:293786	13/50 (26%)
		ANK repeat	148..182	CDD:293786	16/33 (48%)
		TRP_2	189..247	CDD:285535	26/57 (46%)
		FTSW_RODA_SPOVE	573..>656	CDD:294347	23/104 (22%)
		PCRF	767..>837	CDD:305100	18/69 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910