DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trpl and trpc2b

DIOPT Version :9

Sequence 1:	NP_476895.1	Gene:	trpl / 36003	FlyBaseID:	FBgn0005614	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	NP_001025337.1	Gene:	trpc2b / 562120	ZFINID:	ZDB-GENE-050712-3	Length:	1140	Species:	Danio rerio

Alignment Length:	964	Identity:	283/964 - (29%)
Similarity:	453/964 - (46%)	Gaps:	179/964 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 KKF------LLAVERGDMPNVRRILQKA---LRHQHININCMDPLGRRALTLAI--DNENLEMVE 96
            |||      |.|:..|::..|..:|:..   :|...   :..|...|.||.|:|  .||: .|..
Zfish    15 KKFRFPPELLGAIREGNLNLVSSLLKTGDGIIRQLD---DSEDRQWREALNLSIRLGNED-TMAS 75

  Fly    97 LLVVMGV-----ETKDALLHAINAEFVEAVELLLEHEELIYKEGEPYSWQKVD------------ 144
            ||  .||     :..:|||.|::......|:.||  :.|..::|     .|:|
Zfish    76 LL--QGVKFDFRQIHEALLVAVDTNQPRVVKRLL--DRLDQEKG-----NKMDVRSFSMAIFDHS 131

  Fly   145 INTAMFAPDITPLMLAAHKNNFEILRILLDRGAAVPVPHDIRCGCEECVRLTAEDSLRHSLSRVN 209
            |:.:.|||.:|||.||..|:.::|:.:|..:|..:|.||.|.|.|.||......|.|:.||||:|
Zfish   132 IDDSQFAPGVTPLTLACQKDLYDIVTMLNQKGHEIPWPHKISCACLECTNGRQYDLLKFSLSRIN 196

  Fly   210 IYRALCSPSLICLTSNDPIITAFQLSWELRNLALTEQECKSEYMDLRRQCQKFAVDLLDQTRTSN 274
            .||.:.|.:.:.:|:.|.:::||:||.:||.|:..|.|.|.:|:.|.:.||:|||:||...|..:
Zfish   197 TYRGIASRAYLSITAEDAMLSAFRLSRDLRKLSKKEPEFKPQYLSLEQVCQEFAVELLGMCRNQS 261

  Fly   275 ELAIILNY--DPQMSSYEPGDRM-------SLTRLVQAISYKQKKFVAHSNIQQLLSSIWYDGLP 330
            |:..|||.  |....|.:..|..       :|.||..|::|.||:||||...||:|||||...|.
Zfish   262 EVTTILNSCGDRDEDSEDELDHQTFEEGIPNLARLRLAVNYNQKQFVAHPICQQVLSSIWCGNLS 326

  Fly   331 GFRRKSIVDKVICIAQVAVLFPLYCLIYMCAPNCRTGQLMRKPFMKFLIHASSYLFFLFILILVS 395
            |:|......|::....:.:..|..||||..||..:.|::::.|.:|||:|::||::|| |.:|..
Zfish   327 GWRGSRTSWKLLVSFGIFLTMPFLCLIYWIAPKSKLGKILKIPVIKFLLHSASYMWFL-ITLLGE 390

  Fly   396 QRADDDFVRIFGTTRMKKELAEQELRQRGQTPSKLELIVVMYVIGFVWEEVQEIFAVGMKSYLRN 460
            ..|.:.:...|.|            ||.....:...::   :|:||.|.|.:|::..|::||..:
Zfish   391 SIAMEVYRESFAT------------RQHTILHNSFHMV---WVVGFFWFECKEVWIEGLRSYFLD 440

  Fly   461 MWNFIDFLRNSLYVSVMCLRAFAYIQ---------------QATEIARDPQMAYIPREKWHDFDP 510
            .||.:|.:..|:|::...||....::               ..||..||         :||..||
Zfish   441 WWNCLDVMVLSMYLASFALRLVIMLKVHFLCQLQDNQDECVYFTETMRD---------QWHQEDP 496

  Fly   511 QLIAEGLFAAANVFSALKLVHLFSINPHLGPLQISLGRMVIDIVKFFFIYTLVLFAFACGLNQLL 575
            |.|:|.|||..::.|..:|.::...:..||.||||:|:|:.|:::|.||..::..||.||:|.:
Zfish   497 QFISEVLFAVTSMLSFTRLAYILPAHESLGTLQISIGKMIDDMMRFMFILVIIGTAFLCGINNI- 560

  Fly   576 WYFAALEKSKCYVLPGGEADWGSHGDSCMKWRRFGNLFESSQSLFWASFGM-----VGLDDFELS 635
             |..       |::.                ...|.|.|:...|||..|||     |.:..|.|:
Zfish   561 -YVP-------YIIS----------------PNLGKLNETFSFLFWTMFGMADQTYVDMPAFALA 601

  Fly   636 GIKSYTRFWGLLMFGSYSVINVIVLLNLLIAMMSNSYAMIDEHSDTEWKFARTKLWMSYFEDSAT 700
            .:.      |.:::|.|::|.||||||:||||::||:..|::.:|.||||||:||::|||.:..|
Zfish   602 ELV------GRILYGIYTLIIVIVLLNMLIAMITNSFQKIEDDADVEWKFARSKLYLSYFREGLT 660

  Fly   701 LPPPFNVLPSVKWVIRIFRKSSKTI-----------DRQRSKKRKEQEQFSE-----YDNIMRSL 749
            :|.|||::||.|.|..:.|...|.|           |.......|::....|     ...::|:|
Zfish   661 MPVPFNIIPSPKAVFYLLRGIVKRICCCCFNCNSAPDYPPLTSMKDEGGSGENRIPYRQQVIRAL 725

  Fly   750 VWRYVAAMHRKFENNPVSE--DDINEVKSEINTMRYEMLEIFEN----SG---MDVSSANKKERQ 805
            |.||:.:..|:||.....:  :.|.|:...|..:..||.:|..|    ||   .|.|..:.
Zfish   726 VQRYIESARREFEETKRKDVGNRITELSKVIGHLHTEMKQIHSNLFNYSGNTKADPSGDSS---- 786

  Fly   806 PRPRRIKVWERRLMKGFQVAPVQNGCELDAFGNVNGQGEMQEIKVESIPSKPAKETAKERFQRVA 870
                         ..|..:...:|  ....|.|......:||......|::..:|..:||.:...
Zfish   787 -------------FLGKYILGAKN--NFKDFNNERRAPPLQETVRHLEPAETNEEPEEERKEEQN 836

  Fly   871 RTVLLQSTTHKWN-------VVLRAAKDSQIGRCTKNERKSLQ--NLGRAIEEA 915
            ....:.:|....|       :.:.::.|::.|.......|:.:  :|...:||:
Zfish   837 AEEQIDNTLQTGNDDANKIVIEIESSPDAESGNAADKMEKAKEGTDLNGDVEES 890

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trpl	NP_476895.1	trp	48..784	CDD:273311	253/804 (31%)
		ANK	48..195	CDD:238125	50/168 (30%)
		ANK repeat	78..114	CDD:293786	16/42 (38%)
		ANK repeat	134..177	CDD:293786	15/54 (28%)
		TRP_2	187..246	CDD:285535	23/58 (40%)
		DUF2031	<706..>805	CDD:299055	30/123 (24%)
trpc2b	NP_001025337.1	trp	23..762	CDD:273311	254/807 (31%)
		ANK	26..159	CDD:238125	40/145 (28%)
		ANK repeat	60..87	CDD:293786	11/29 (38%)
		ANK repeat	89..134	CDD:293786	12/51 (24%)
		ANK repeat	136..164	CDD:293786	11/27 (41%)
		TRP_2	174..233	CDD:285535	23/58 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3609
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000660
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	5	4.770