Protein Alignment trpl and trpc5b

DIOPT Version :10

• Sequence 1: NP_476895.1
• Gene: trpl / 36003
• FlyBaseID: FBgn0005614
• Length: 1124
• Species: Drosophila melanogaster
• Sequence 2: XP_073791538.1
• Gene: trpc5b / 559586
• ZFINID: ZDB-GENE-091112-24
• Length: 1026
• Species: Danio rerio
• Alignment Length: 1070
• Identity: 397/1070 - (37%)
• Similarity: 592/1070 - (55%)
• Gaps: 164/1070 - (15%)

  Fly    30 VPLGLPQ---PLLLEEKKFLLAVERGDMPNVRRILQKALRHQHININCMDPLGRRALTLAIDNEN 91
            :||.:.:   .|..:|:.:|.|||:||...|::.|::|..:.:||:||:|||||.||.:||:|||
Zfish    21 IPLQIVRAEVELSAKERAYLTAVEKGDYAGVKQALEEADIYYNINVNCLDPLGRSALLIAIENEN 85

  Fly    92 LEMVELLVVMGVETKDALLHAINAEFVEAVELLLEHEELIYKEGEPYSWQKVDINTAMFAPDITP 156
            ||::|||:..||.|.||||:||..|.|.||||||.:.:...::..|.  ..:|...:.|.|||||
Zfish    86 LEVMELLLSHGVHTGDALLYAIRKEVVGAVELLLSYRKPCGEKQVPS--LMMDTQFSEFTPDITP 148

  Fly   157 LMLAAHKNNFEILRILLDRGAAVPVPHDIRCGCEECVRLTAEDSLRHSLSRVNIYRALCSPSLIC 221
            :|||||.||:||:::|:.|...:|.||.|||.|.|||..:..||||||.||:|||:||.|||||.
Zfish   149 IMLAAHTNNYEIIKLLVQRKVTIPRPHQIRCDCVECVSSSEVDSLRHSRSRLNIYKALASPSLIA 213

  Fly   222 LTSNDPIITAFQLSWELRNLALTEQECKSEYMDLRRQCQKFAVDLLDQTRTSNELAIILNY-DPQ 285
            |:|.|||:|||:|.|||:.|:..|.|.:.||.:|.:||:.||.|||||.|:|.||..|||: |..
Zfish   214 LSSEDPILTAFRLGWELKELSKVENEFRQEYDELSQQCKLFAKDLLDQARSSRELETILNHRDDH 278

  Fly   286 MSSYEPGDRMSLTRLVQAISYKQKKFVAHSNIQQLLSSIWYDGLPGFRRKSIVDKVICIAQVAVL 350
            ....:.|:...|.:|..||.|.||:|||..|.||||:::||||.||:||:....|::....:.:|
Zfish   279 SEELDLGECRDLAKLKLAIKYHQKEFVAQPNCQQLLATLWYDGFPGWRRRHWAVKLVTCFIIGLL 343

  Fly   351 FPLYCLIYMCAPNCRTGQLMRKPFMKFLIHASSYLFFLFILILVSQRADDDFVRIFGTTRMKKEL 415
            ||::.:||:.||....|..::|||:||:.|.:|||.|||:|:|.||                 .:
Zfish   344 FPVFSIIYLLAPKSTLGTFIKKPFIKFICHTASYLTFLFLLLLASQ-----------------HI 391

  Fly   416 AEQELRQRGQTPSKLELIVVMYVIGFVWEEVQEIFAVGMKSYLRNMWNFIDFLRNSLYVSVMCLR 480
            .:.:|..:|..|:.:|.:::.:|:||:|.|::|::..|...|:.:.||.:||..||||::.:.|:
Zfish   392 VQTDLHVQGPPPTFVEWMILPWVLGFIWAEIKEMWDGGFTEYIHDWWNLMDFAMNSLYLATISLK 456

  Fly   481 AFAYIQQATEIARDPQMAYIPREKWHDFDPQLIAEGLFAAANVFSALKLVHLFSINPHLGPLQIS 545
            ..||.:..:.         .||.:|..:.|.||||.|||.||:||:|:|:.||:.|.||||||||
Zfish   457 MVAYFKYNSS---------RPRVEWEMWHPTLIAEALFAIANIFSSLRLISLFTANSHLGPLQIS 512

  Fly   546 LGRMVIDIVKFFFIYTLVLFAFACGLNQLLWYF---AALEKSKCYVLPGGEADWGSHGDSCMKWR 607
            ||||::||:||.|||.|||.|||.|||||.:|:   |:.|.:.|            .|..|.|..
Zfish   513 LGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYETKASEEPNNC------------KGIRCEKQN 565

  Fly   608 R-FGNLFESSQSLFWASFGMVGLDDFELSGIKSYTRFWGLLMFGSYSVINVIVLLNLLIAMMSNS 671
            . |..|||:.|||||:.||::.|....:.....:|.|.|..|||:|:||:::||||:|||||:||
Zfish   566 NAFSTLFETLQSLFWSVFGLLNLYVTNVKARHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNS 630

  Fly   672 YAMIDEHSDTEWKFARTKLWMSYFEDSATLPPPFNVLPSVK--WVIRIF---RKSSKTIDRQRSK 731
            |.:|.:|:|.||||||||||||||::..|||||||::||.|  |.:.::   |.......|...|
Zfish   631 YQLIADHADIEWKFARTKLWMSYFDEGGTLPPPFNIIPSPKSVWYLCVWLHCRLCGHGEPRHEDK 695

  Fly   732 -KRKEQEQFSE-----------YDNIMRSLVWRYVAAMHRKFENNP-VSEDDINEVKSEINTMRY 783
             |.|..::|:|           |..::|:||.||||||.|..:.:. ::|::..|:|.:|::.||
Zfish   696 CKHKNLKEFTERHADNLIQNQHYQEVIRNLVKRYVAAMIRSAKTDEGLTEENFKELKQDISSFRY 760

  Fly   784 EMLEIFENSGMDVSSANKKERQPRPRRIKVWERRLMKGFQVAPVQNGCELDAFGN--VNG----- 841
            |:|::..|            |:| |||.........:..:.|..:   |:|...|  :.|
Zfish   761 EVLDLLGN------------RKP-PRRTYSSSSEATQQDETAEPE---EVDEERNHRLGGHTCVD 809

  Fly   842 QGEMQEIKVESIPSKPAKETAKERF--------------QRVARTVLLQSTTHKWNVVLRAAKDS 892
            :||....|..:..|:..:...:.:|              ::.....|.::.:|....|   ..:|
Zfish   810 EGERSRYKASTSFSQCYRRNRESQFSISALFKSISGPAREKPESNGLRKNISHPSPFV---QTNS 871

  Fly   893 QIGRCTKNERKSLQNLGRAIEEAKRLIMLNPGCPSGRESPIRIEFEDEKTSTLLELLNQISAEIS 957
            ::...:.:::.|||.||..      ::.:|...|......:.::              |.:..||
Zfish   872 RLQHFSHSKKNSLQRLGML------MLRMNGHVPDTHAETLEVQ--------------QSAYSIS 916

  Fly   958 DSEKPKIRPIWRPPLKTVPARAMAANNTRSLTAPELKISRKSSPAPT---------PTPTPGVSH 1013
            |               .||..:.  :|.::|:    |::|..:...|         ..|...:|:
Zfish   917 D---------------RVPQTSW--HNPQNLS----KVTRSETHLHTLGLGALETEENPMHAISN 960

  Fly  1014 TA------LSQFRNRELP--LCPSKLIANS 1035
            .|      ..|.....||  .|.|.|..:|
Zfish   961 RANGSDNLFHQRPGHSLPPLHCASSLTTSS 990

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trpl	NP_476895.1	TRPV	48..784	CDD:454755	341/758 (45%)
		ANK repeat	78..114	CDD:293786	23/35 (66%)
		ANK repeat	134..177	CDD:293786	19/42 (45%)
		TRP_CaM_bind1	798..883	CDD:467881	17/105 (16%)
		PHA03247	<961..1069	CDD:223021	17/92 (18%)
trpc5b	XP_073791538.1	None