Protein Alignment trpl and Trpgamma

DIOPT Version :9

• Sequence 1: NP_476895.1
• Gene: trpl / 36003
• FlyBaseID: FBgn0005614
• Length: 1124
• Species: Drosophila melanogaster
• Sequence 2: NP_001137830.2
• Gene: Trpgamma / 34991
• FlyBaseID: FBgn0032593
• Length: 1188
• Species: Drosophila melanogaster
• Alignment Length: 1144
• Identity: 505/1144 - (44%)
• Similarity: 686/1144 - (59%)
• Gaps: 149/1144 - (13%)

  Fly    38 LLLEEKKFLLAVERGDMPNVRRILQKALRHQHININCMDPLGRRALTLAIDNENLEMVELLVVMG 102
            |.|||||||||||||||...||:||||...::||:||:|||||.||.:|||||||||||||:...
  Fly    78 LTLEEKKFLLAVERGDMAGTRRMLQKAQDTEYINVNCVDPLGRTALLMAIDNENLEMVELLINYN 142

  Fly   103 VETKDALLHAINAEFVEAVELLLEHEELIYKEGEPYSWQKVDINTAMFAPDITPLMLAAHKNNFE 167
            |:|||||||:|:.|||||||:||:||.:.:.....:||:....:|:.|.||||||:||||::|:|
  Fly   143 VDTKDALLHSISEEFVEAVEVLLDHENVTFHSEGNHSWESASEDTSTFTPDITPLILAAHRDNYE 207

  Fly   168 ILRILLDRGAAVPVPHDIRCGCEECVRLTAEDSLRHSLSRVNIYRALCSPSLICLTSNDPIITAF 232
            |::|||||||.:|:|||:||||:|||:...|||||||.||:|.||||.|||||.|:|.|||:|||
  Fly   208 IIKILLDRGAVLPMPHDVRCGCDECVQSRQEDSLRHSRSRINAYRALASPSLIALSSKDPILTAF 272

  Fly   233 QLSWELRNLALTEQECKSEYMDLRRQCQKFAVDLLDQTRTSNELAIILNYDPQMSSYEPGDRMSL 297
            :||||||.|:..|.|.|:||.:||:|||.||..|||.||||:||.|:||:||....||.|:||.|
  Fly   273 ELSWELRRLSFLEHEFKNEYQELRKQCQDFATALLDHTRTSHELEILLNHDPTGPVYEHGERMHL 337

  Fly   298 TRLVQAISYKQKKFVAHSNIQQLLSSIWYDGLPGFRRKSIVDKVICIAQVAVLFPLYCLIYMCAP 362
            .||..||..:|||||||||:||||:||||:||||||||::..:.:.|.::.::||::.|.|:.||
  Fly   338 NRLKLAIKLRQKKFVAHSNVQQLLASIWYEGLPGFRRKNMALQAVDIIRIGIMFPIFSLAYILAP 402

  Fly   363 NCRTGQLMRKPFMKFLIHASSYLFFLFILILVSQRADDDFVR--IFGTTRMKKELAEQELRQRGQ 425
            ....||.|||||:||:.|::||..|||:|:|.|||. :.|:.  .|..:.......|:...:||.
  Fly   403 YSSIGQTMRKPFIKFICHSASYFTFLFLLMLASQRI-ETFIGGWFFADSSGMLNTMEELPTKRGA 466

  Fly   426 TPSKLELIVVMYVIGFVWEEVQEIFAVGMKSYLRNMWNFIDFLRNSLYVSVMCLRAFAYIQQATE 490
            .|:.:|.:::.:|.|.:|.||::::.||::.||.:|||.|||:.|||||:.:.||..::.|...|
  Fly   467 KPTFIEWLILAWVSGLIWSEVKQLWDVGLQEYLNDMWNVIDFVTNSLYVATVALRVVSFFQVQKE 531

  Fly   491 IARDPQMAYIPREKWHDFDPQLIAEGLFAAANVFSALKLVHLFSINPHLGPLQISLGRMVIDIVK 555
            :..:.....:|||:|..:||.||:||||:|||:||:||||::||:||||||||:||.|||:||:|
  Fly   532 MIYNSHATDLPRERWDAWDPMLISEGLFSAANIFSSLKLVYIFSVNPHLGPLQVSLSRMVMDIMK 596

  Fly   556 FFFIYTLVLFAFACGLNQLLWYFAALEKSKCYVLPGGEADWGSHG----DSCMKWRRFGNLFESS 616
            |||:|.||||||..||||||||:|.|||.:|..:....|....:|    ::|:.||||.||||::
  Fly   597 FFFLYVLVLFAFGSGLNQLLWYYADLEKKRCPEVSPMSALLNMNGTNDPNACIVWRRFSNLFETT 661

  Fly   617 QSLFWASFGMVGLDDFELSGIKSYTRFWGLLMFGSYSVINVIVLLNLLIAMMSNSYAMIDEHSDT 681
            |:||||.||::.||.|||.|||.:|||||:||||:|||||::||||||||||::||.:|.|.:|.
  Fly   662 QTLFWAVFGLIDLDSFELDGIKIFTRFWGMLMFGTYSVINIVVLLNLLIAMMNHSYQLISERADV 726

  Fly   682 EWKFARTKLWMSYFEDSATLPPPFNVLP-------SVKWVIRIFRKSSKTIDRQRSKK-RKEQEQ 738
            ||||||:|||:||||:..|.|||||::|       ::||:.|:|...|....|:..|. |::.:|
  Fly   727 EWKFARSKLWISYFEEGGTCPPPFNIIPTPKSIWYAIKWMRRVFCSGSSAARREHLKTIRRKAQQ 791

  Fly   739 FSE----YDNIMRSLVWRYVAAMHRKFENNPVSEDDINEVKSEINTMRYEMLEIFENSGMDVS-- 797
            .|:    |..|||:||.|||....||.|:..|:|||:||:|.:|:..|.|::||.:|||||.:
  Fly   792 ASDRDFKYQQIMRNLVRRYVTVEQRKAESQGVTEDDVNEIKQDISAFRCELVEILKNSGMDTNVT 856

  Fly   798 -----SANKKERQPRPRRIKVWERRLMKGFQVAP----------VQNGCELDAFGNVNGQGEMQE 847
                 ...||.||.        ||||||||.:||          .:....||   |.:.|.|:..
  Fly   857 AGQGGGGGKKNRQK--------ERRLMKGFNIAPPGSTGSLAPVAEFSTSLD---NYDNQHEILS 910

  Fly   848 IKVESI--------------------PSKPAKETAKERFQRVARTVLLQSTTH------------ 880
            ..:.::                    ...|...||.:..|..|.|...|.|.:
  Fly   911 STLSTLFTPNFMHKRQQSQAGSGGGGSESPTTPTAPQGTQGAAMTASSQVTKYNKSALKPYNKRI 975

  Fly   881 -----KWNVVLRAAKDSQIGRCTKNERKSLQNLGRAIEEAKRLIMLNPGCPSGRES-PI----RI 935
                 :|..::.|||   :|..:|       .|||:..|       :..|.|...| |:    |:
  Fly   976 AGHKKRWGTLIEAAK---VGNVSK-------MLGRSKSE-------DSVCNSSHTSTPVHGQMRV 1023

  Fly   936 EFEDEKTSTLLELLNQISAEISDSEKPKIRPIWRPPLKTVPARAMAANNTRSLTA-PELKISRKS 999
            .:.............:.|:....:..|.|..:...|.......:...:.|..||| ..||..||.
  Fly  1024 TYAQNSPQQEYGYHGETSSTTISTPTPTISVVSNSPAAHAGVGSHFFHTTSGLTAIAALKRKRKK 1088

  Fly  1000 SPAPTPTPTPGVSHTALSQFRNRELPLCP---SKLIANSAP--SAPTAPPKKSAPTA-------P 1052
                            .|..:|    :||   |...||:|.  :..|.....|.|.|       |
  Fly  1089 ----------------FSSSKN----ICPVTESVAAANAAEILNDKTLKRVSSYPAAEAGVQHNP 1133

  Fly  1053 TPTYKPTTHAPFSVEGGNRENTRASDGVRSDNSNFDIHV 1091
            ....||..|          |.|::.......||.|.:.:
  Fly  1134 AQLVKPRRH----------EQTQSQHDSVETNSTFTLSI 1162

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trpl	NP_476895.1	trp	48..784	CDD:273311	413/753 (55%)
		ANK	48..195	CDD:238125	92/146 (63%)
		ANK repeat	78..114	CDD:293786	26/35 (74%)
		ANK repeat	134..177	CDD:293786	22/42 (52%)
		TRP_2	187..246	CDD:285535	40/58 (69%)
		DUF2031	<706..>805	CDD:299055	43/117 (37%)
Trpgamma	NP_001137830.2	trp	77..841	CDD:273311	422/763 (55%)
		ANK	113..>217	CDD:238125	64/103 (62%)
		ANK repeat	118..147	CDD:293786	20/28 (71%)
		ANK repeat	175..217	CDD:293786	22/41 (54%)
		TRP_2	227..286	CDD:285535	40/58 (69%)
		RRT14	<778..892	CDD:293680	48/121 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450244
Domainoid	1	1.000	270	1.000	Domainoid score	I1782
eggNOG	1	0.900	-	-		E1_KOG3609
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	774	1.000	Inparanoid score	I517
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D13813at33392
OrthoFinder	1	1.000	-	-		FOG0000660
OrthoInspector	1	1.000	-	-		mtm6331
orthoMCL	1	0.900	-	-		OOG6_102173
Panther	1	1.100	-	-	P	PTHR10117
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X802
	11	10.800