Protein Alignment trpl and Trpc7

DIOPT Version :9

• Sequence 1: NP_476895.1
• Gene: trpl / 36003
• FlyBaseID: FBgn0005614
• Length: 1124
• Species: Drosophila melanogaster
• Sequence 2: XP_006517325.1
• Gene: Trpc7 / 26946
• MGIID: 1349470
• Length: 906
• Species: Mus musculus
• Alignment Length: 819
• Identity: 269/819 - (32%)
• Similarity: 410/819 - (50%)
• Gaps: 163/819 - (19%)

  Fly    41 EEKKFLLAVERGDMPNVRRILQKALRHQHININCMDPLGRRALTLAIDNENLEMVELLVVMG--V 103
            ||::||.:.|.|::|.||::|:::   :.:|.||:|.:|:.||.||:.||:||:.|||:...  .
Mouse   142 EEERFLDSAEYGNIPVVRKMLEES---KTLNFNCVDYMGQNALQLAVGNEHLEVTELLLKKENLA 203

  Fly   104 ETKDALLHAINAEFVEAVELLLEH---------------EELIYKEGEPYSWQKVDINTAMFAPD 153
            ...||||.||:..:|..||.:|.|               :||  ::.:.|::   |.:...|:.|
Mouse   204 RVGDALLLAISKGYVRIVEAILSHPAFAQGQRLTLSPLEQEL--RDDDFYAY---DEDGTRFSHD 263

  Fly   154 ITPLMLAAHKNNFEILRILLDRGAAVPVPHDIRCGCEECVRLTAEDSLRHSLSRVNIYRALCSPS 218
            |||::||||...:||:.|||.:||.:..|||..|.|.||.....:||..||.||:|.|:.|.|.:
Mouse   264 ITPIILAAHCQEYEIVHILLLKGARIERPHDYFCKCNECTEKQRKDSFSHSRSRMNAYKGLASAA 328

  Fly   219 LICLTSNDPIITAFQLSWELRNLALTEQECKSEYMDLRRQCQKFAVDLLDQTRTSNELAIILNYD 283
            .:.|:|.||::||.:||.||..||..|.|.|::|..|..||:.|.|.:||..|.:.|:..|||.|
Mouse   329 YLSLSSEDPVLTALELSNELARLANIETEFKNDYRKLSMQCKDFVVGVLDLCRDTEEVEAILNGD 393

  Fly   284 PQMSSYEPGDRMSLTRLVQAISYKQKKFVAHSNIQQLLSSIWYDGLPGFRRKSIVDKVICIAQVA 348
            ..:..:....|.||:|:..||.|:.||.
Mouse   394 VNLQVWSDHHRPSLSRIKLAIKYEVKKL------------------------------------- 421

  Fly   349 VLFPLYCLIYMCAPNCRTGQLMRKPFMKFLIHASSYLFFLFILILVSQRADDDFVRIFGTTRMKK 413
                              ||.:|.|||||:.||.|:..||.:|::   .|.|   |..|...:..
Mouse   422 ------------------GQTLRSPFMKFVAHAVSFTIFLGLLVV---NASD---RFEGVKTLPN 462

  Fly   414 E----LAEQELRQRGQTPSKLELIVVMYVIGFVWEEVQEIFAVGMKSYLRNMWNFIDFLRNSLYV 474
            |    ..:|..|.:....|..|::::.:|:|.:|.|.:||:..|.:.|:.::||.:||...|::|
Mouse   463 ETFTDYPKQIFRVKTTQFSWTEMLIMKWVLGMIWSECKEIWEEGPREYVLHLWNLLDFGMLSIFV 527

  Fly   475 SVMCLRAFA-------------YIQQAT--EIARDPQMAYI--PREKWHDFDPQLIAEGLFAAAN 522
            :....|..|             |:|..|  .::..|::||.  .|:||...|||:|:|||:|.|.
Mouse   528 ASFTARFMAFLKASEAQLYVDQYVQDVTLHNVSLPPEVAYFTYARDKWWPSDPQIISEGLYAIAV 592

  Fly   523 VFSALKLVHLFSINPHLGPLQISLGRMVIDIVKFFFIYTLVLFAFACGLNQLLWYFAALEKSKCY 587
            |.|..::.::...|...|||||||||.|.||.||..|:.:|..||..|:..|..|:...:.:..
Mouse   593 VLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYRGAKYNPA- 656

  Fly   588 VLPGGEADWGSHGDSCMKWRRFGNLFESSQSLFWASFGMVGLDDFELSGIKSYTRFWGLLMFGSY 652
                                 |..:.||.::|||:.||:..:....|.....:....|.:::|.|
Mouse   657 ---------------------FTTVEESFKTLFWSIFGLSEVISVVLKYDHKFIENIGYVLYGVY 700

  Fly   653 SVINVIVLLNLLIAMMSNSYAMIDEHSDTEWKFARTKLWMSYFEDSATLPPPFNVLPSVK----W 713
            :|..|:||||:||||::|||..|:|.:|.||||||.|||:|||::..|||.|||::||.|    .
Mouse   701 NVTMVVVLLNMLIAMINNSYQEIEEDADVEWKFARAKLWLSYFDEGRTLPAPFNLVPSPKSFYYL 765

  Fly   714 VIRI---------------------------FRKSSKTIDRQRSKKRKEQEQFSE---YDNIMRS 748
            ::||                           |||:......:.|:.......||:   |..||:.
Mouse   766 IMRIKMCLIELCQSKAKRCENDLEMGMLNSKFRKTRYQAGMRNSENLTANSTFSKPTRYQKIMKR 830

  Fly   749 LVWRYVAAMHRKFENNPVSEDDINEVKSEINTMRYEMLE 787
            |:.|||.......||:.|:|.::.|:|.:|:::|||:||
Mouse   831 LIKRYVLKAQVDRENDEVNEGELKEIKQDISSLRYELLE 869

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trpl	NP_476895.1	trp	48..784	CDD:273311	261/807 (32%)
		ANK	48..195	CDD:238125	60/163 (37%)
		ANK repeat	78..114	CDD:293786	17/37 (46%)
		ANK repeat	134..177	CDD:293786	16/42 (38%)
		TRP_2	187..246	CDD:285535	26/58 (45%)
		DUF2031	<706..>805	CDD:299055	31/116 (27%)
Trpc7	XP_006517325.1	trp	126..866	CDD:273311	265/814 (33%)
		ANK repeat	176..207	CDD:293786	12/30 (40%)
		ANK repeat	208..254	CDD:293786	13/50 (26%)
		ANK repeat	256..291	CDD:293786	16/34 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3609
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.770